Tubuloglomerular feedback responses of the downstream efferent resistance: unmasking a role for adenosine?

This Commentary aims to integrate or interrelate the available in vivo data with the in vitro study by Ren and co-workers, which comes to the somewhat surprising conclusion that tubuloglomerular feedback activation vasodilates the efferent arteriole by an adenosine-dependent mechanism.

[1]  V. Vallon,et al.  Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback. , 2000, The Journal of clinical investigation.

[2]  R. Blantz,et al.  Feedback pressure-flow responses in normal and angiotensin-prostaglandin-blocked rats. , 1984, The American journal of physiology.

[3]  F. S. Wright,et al.  Feedback control of glomerular filtration rate: site of the effector mechanism. , 1979, The American journal of physiology.

[4]  B. Brenner,et al.  The dynamics of glomerular ultrafiltration in the rat. , 1971, The Journal of clinical investigation.

[5]  R. Blantz,et al.  An analysis of the determinants of nephron filtration rate. , 1977, The American journal of physiology.

[6]  B. J. Tucker,et al.  Studies on the tubulo-glomerular feedback system in the rat. The mechanism of reduction in filtration rate with benzolamide. , 1978, The Journal of clinical investigation.

[7]  B. Brenner,et al.  Dynamics of glomerular ultrafiltration in the rat. 3. Hemodynamics and autoregulation. , 1972, The American journal of physiology.

[8]  R. Blantz,et al.  Asymmetry of tubuloglomerular feedback effector mechanism with respect to ambient tubular flow. , 1996, The American journal of physiology.

[9]  O. Carretero,et al.  Possible mechanism of efferent arteriole (Ef-Art) tubuloglomerular feedback. , 2007, Kidney international.

[10]  I. Ichikawa.  Direct analysis of the effector mechanism of the tubuloglomerular feedback system. , 1982, The American journal of physiology.

[11]  V. Vallon,et al.  Adenosine and kidney function. , 2006, Physiological reviews.