Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells

[1]  K. Hoffmann‐Sommergruber,et al.  Differential T-Helper Cell Polarization after Allergen-Specific Stimulation of Autologous Dendritic Cells in Polysensitized Allergic Patients , 2015, International Archives of Allergy and Immunology.

[2]  C. Akdis,et al.  Mechanisms of allergen-specific immunotherapy , 2012, Clinical and Translational Allergy.

[3]  J. Enghild,et al.  The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes. , 2007, Biochemistry.

[4]  J. Griss,et al.  Proteome signatures of inflammatory activated primary human peripheral blood mononuclear cells , 2012, Journal of proteomics.

[5]  G. Zlabinger,et al.  A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T‐cell activation , 2012, Allergy.

[6]  F. Giorgianni,et al.  Proteome of monocyte priming by lipopolysaccharide, including changes in interleukin-1beta and leukocyte elastase inhibitor , 2008, Proteome Science.

[7]  S. Henrickson,et al.  T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases , 2004, Nature.

[8]  M. Wallner,et al.  Pollen Allergens for Molecular Diagnosis , 2016, Current Allergy and Asthma Reports.

[9]  G. Karupiah,et al.  NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response. , 2000, Reviews in immunogenetics.

[10]  M. Kaplan,et al.  STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation , 2016, Immune network.

[11]  A. Duschl,et al.  Residual Endotoxin Contaminations in Recombinant Proteins Are Sufficient to Activate Human CD1c+ Dendritic Cells , 2014, PloS one.

[12]  M. Pallardy,et al.  Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy. , 2016, The Journal of allergy and clinical immunology.

[13]  K. Triantafilou,et al.  Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. , 2002, Trends in immunology.

[14]  S. Scheurer,et al.  What makes an allergen? , 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[15]  Martin J. Mueller,et al.  Abbreviations used: Bet.-APE, , 2022 .

[16]  F. Alessandrini,et al.  Pollen‐derived nonallergenic substances enhance Th2‐induced IgE production in B cells , 2015, Allergy.

[17]  D. Bagarozzi,et al.  Ragweed pollen proteolytic enzymes: possible roles in allergies and asthma. , 1998, Phytochemistry.

[18]  O. Wagner,et al.  Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells. , 2009, Journal of proteome research.

[19]  H. Behrendt,et al.  Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo , 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[20]  H. Gadgil,et al.  Proteome of monocytes primed with lipopolysaccharide: Analysis of the abundant proteins , 2003, Proteomics.

[21]  R. Valenta,et al.  Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. , 1998, The Journal of allergy and clinical immunology.

[22]  I. Boldogh,et al.  Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. , 2005, The Journal of allergy and clinical immunology.

[23]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[24]  P. Moingeon,et al.  Allergen immunotherapy for birch pollen-allergic patients: recent advances. , 2016, Immunotherapy.

[25]  Albert-László Barabási,et al.  PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation , 2016, Nature Communications.

[26]  Shengjie Li,et al.  Recent Advances , 2018, Journal of Optimization Theory and Applications.

[27]  Matthias Mann,et al.  Quantitative shotgun proteomics: considerations for a high-quality workflow in immunology , 2014, Nature Immunology.

[28]  José A. Dianes,et al.  2016 update of the PRIDE database and its related tools , 2016, Nucleic Acids Res..

[29]  R. Lefkowitz,et al.  The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins , 2000, The Journal of Biological Chemistry.

[30]  C. Karp Guilt by intimate association: what makes an allergen an allergen? , 2010, The Journal of allergy and clinical immunology.

[31]  Kathleen M. Smith,et al.  Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP , 2002, Nature Immunology.

[32]  M. Fortini,et al.  Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling , 2002, Nature Reviews Molecular Cell Biology.

[33]  H. Na,et al.  Regulation of Th2 Cell Immunity by Dendritic Cells , 2016, Immune network.

[34]  A. Ghaemmaghami,et al.  The molecular basis of allergenicity. , 2008, Trends in immunology.

[35]  L. A. Feeney,et al.  Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family , 2001, The Journal of Immunology.

[36]  Kristian E. Swearingen,et al.  Proteomic profiling of lipopolysaccharide-activated macrophages by isotope coded affinity tagging. , 2010, Journal of proteome research.

[37]  M. Loda,et al.  Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1 , 2000, Nature.

[38]  Mikhail Sofiev,et al.  Allergenic Pollen: A Review of the Production, Release, Distribution and Health Impacts , 2013 .

[39]  M. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization , 2003, Nature Reviews Immunology.

[40]  Kim Bottomly,et al.  Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen , 2002, The Journal of experimental medicine.

[41]  K. Matsushima,et al.  Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. , 1999, International immunology.

[42]  A. Veillette SLAM-family receptors: immune regulators with or without SAP-family adaptors. , 2010, Cold Spring Harbor perspectives in biology.

[43]  Bali Pulendran,et al.  Programming dendritic cells to induce TH2 and tolerogenic responses , 2010, Nature Immunology.

[44]  H. Behrendt,et al.  Determinants of allergenicity. , 2009, The Journal of allergy and clinical immunology.

[45]  I. Boldogh,et al.  Innate responses to pollen allergens , 2015, Current opinion in allergy and clinical immunology.

[46]  B. Beutler,et al.  Identification of a TLR4‐ and TRIF‐dependent activation program of dendritic cells , 2004, European journal of immunology.

[47]  A. Linneberg,et al.  The increase in allergy and extended challenges , 2011, Allergy.

[48]  M. Kaplan,et al.  Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis. , 2014, The Journal of allergy and clinical immunology.

[49]  F. Sallusto,et al.  Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha , 1994, The Journal of experimental medicine.

[50]  A. Duschl,et al.  STAT6-dependent and -independent mechanisms in Th2 polarization , 2012, European journal of immunology.

[51]  Beatriz León,et al.  Monocyte-derived dendritic cells. , 2005, Seminars in immunology.