Adsorption Behavior of Penicillin G Sodium on Hydrophilic Gel Toyopearl HW-40F

The adsorption of penicillin G sodium (PGS) on a hydrophilic gel, Toyopearl HW-40F, was investigated by the frontal analysis method. Effects of media, buffer concentration, and temperature on the adsorption equilibrium were examined in the buffer concentration range of (0.005 to 0.05) mol·L−1 and temperature range of (278.15 to 308.15) K. At the same pH value, the ionic strength of the mobile phase greatly influences the adsorption of PGS. The adsorption isotherms of PGS are comparable at different temperatures. The equilibrium data were modeled by the Freundlich equation with AARD in the range of (0.86 to 7.15) %.

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