Intranasal antisepsis to reduce influenza virus transmission in an animal model

Seasonal influenza annually causes significant morbidity and mortality, and unpredictable respiratory virus zoonoses, such as the current COVID‐19 pandemic, can threaten the health and lives of millions more. Molecular iodine (I2) is a broad‐spectrum, pathogen‐nonspecific antiseptic agent that has demonstrated antimicrobial activity against a wide range of bacteria, virus, and fungi.

[1]  Keda Chen,et al.  Virucidal effect of povidone-iodine against SARS-CoV-2 in vitro , 2021, The Journal of international medical research.

[2]  B. Zeigelboim,et al.  Front lines of the COVID-19 pandemic: what is the effectiveness of using personal protective equipment in health service environments?—a systematic review , 2021, International Archives of Occupational and Environmental Health.

[3]  Eric H. Young,et al.  National Prevalence of Influenza Diagnoses and Vaccination Rates Among Patients Presenting to United States Physician Offices and Hospital Outpatient Departments, 2009 to 2016 , 2021, Open forum infectious diseases.

[4]  Anice C. Lowen,et al.  Quantitative Approach To Assess Influenza A Virus Fitness and Transmission in Guinea Pigs , 2021, Journal of Virology.

[5]  Wan Yang,et al.  Effectiveness of non-pharmaceutical interventions to contain COVID-19: a case study of the 2020 spring pandemic wave in New York City , 2021, Journal of the Royal Society Interface.

[6]  H. Ullum,et al.  Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers , 2020, Annals of Internal Medicine.

[7]  R. Webby,et al.  Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand , 2020, medRxiv.

[8]  J. Maillard,et al.  Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization , 2020, Antimicrobial Agents and Chemotherapy.

[9]  A. Bidra,et al.  Rapid In‐Vitro Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Using Povidone‐Iodine Oral Antiseptic Rinse , 2020, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[10]  S. Schultz-Cherry,et al.  Direct interactions with influenza promote bacterial adherence during respiratory infections , 2019, Nature Microbiology.

[11]  M. Stockwell,et al.  Economic burden of seasonal influenza in the United States. , 2018, Vaccine.

[12]  M. Eickmann,et al.  In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens , 2018, Infectious Diseases and Therapy.

[13]  Richard D. Morey,et al.  Baysefactor: Computation of Bayes Factors for Common Designs , 2018 .

[14]  P. Bigliardi,et al.  Povidone iodine in wound healing: A review of current concepts and practices. , 2017, International journal of surgery.

[15]  Jonathon Love,et al.  UvA-DARE ( Digital Academic Repository ) Default “ Gunel and Dickey ” Bayes factors for contingency tables , 2016 .

[16]  Brian Burnikel,et al.  Is Preoperative Nasal Povidone-Iodine as Efficient and Cost-Effective as Standard Methicillin-Resistant Staphylococcus aureus Screening Protocol in Total Joint Arthroplasty? , 2016, The Journal of arthroplasty.

[17]  Su-ling Hong,et al.  Establishment of a new animal model of allergic rhinitis with biphasic sneezing by intranasal sensitization with Staphylococcal enterotoxin B. , 2015, Experimental and therapeutic medicine.

[18]  Hong-Sheng Zhang,et al.  Effects of Xingbi gel on leukotriene E4 and immunoglobulin E production and nasal eosinophilia in a guinea pig model for allergic rhinitis. , 2015, Asian Pacific journal of allergy and immunology.

[19]  M. Peterson,et al.  Efficacy of Skin and Nasal Povidone-Iodine Preparation against Mupirocin-Resistant Methicillin-Resistant Staphylococcus aureus and S. aureus within the Anterior Nares , 2015, Antimicrobial Agents and Chemotherapy.

[20]  Nicole M. Bouvier,et al.  Transmission in the Guinea Pig Model , 2014, Current topics in microbiology and immunology.

[21]  K. Kraemer,et al.  Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution , 2014, Infection Control & Hospital Epidemiology.

[22]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[23]  R. Compans,et al.  Current Topics in Microbiology and Immunology , 1970, Current Topics in Microbiology and Immunology.

[24]  A. Busza,et al.  Effect of the TRPV1 antagonist SB‐705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig , 2013, British journal of pharmacology.

[25]  G. Mcdonnell,et al.  Disinfection: is it time to reconsider Spaulding? , 2011, The Journal of hospital infection.

[26]  Tom Jefferson,et al.  Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review , 2008, BMJ : British Medical Journal.

[27]  A. Kramer,et al.  Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. , 2010, The Journal of antimicrobial chemotherapy.

[28]  Nicole M. Bouvier,et al.  Animal Models for Influenza Virus Pathogenesis and Transmission , 2010, Viruses.

[29]  Y Zhou,et al.  Face masks to prevent transmission of influenza virus: a systematic review , 2010, Epidemiology and Infection.

[30]  P. Wilairat,et al.  Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities , 2009, Virology Journal.

[31]  Jigar H. Shah,et al.  Validation of guinea pig model of allergic rhinitis by oral and topical drugs. , 2008, International immunopharmacology.

[32]  Nicole M. Bouvier,et al.  Oseltamivir-Resistant Influenza A Viruses Are Transmitted Efficiently among Guinea Pigs by Direct Contact but Not by Aerosol , 2008, Journal of Virology.

[33]  J. A. Navarro,et al.  Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic. , 2007, JAMA.

[34]  C. Bridges,et al.  The annual impact of seasonal influenza in the US: measuring disease burden and costs. , 2007, Vaccine.

[35]  M. Walker,et al.  A comprehensive model of allergic rhinitis in guinea pigs. , 2007, Journal of pharmacological and toxicological methods.

[36]  H. Klenk,et al.  New low-viscosity overlay medium for viral plaque assays , 2006, Virology Journal.

[37]  Adolfo García-Sastre,et al.  The guinea pig as a transmission model for human influenza viruses. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Walter Sneader,et al.  Drug Discovery (The History) , 2005 .

[39]  R. Ruffolo,et al.  Drug discovery , 2005, Nature Biotechnology.

[40]  Bernhardt,et al.  Einzelreferate und Buchbesprechungen , 2005, Klinische Wochenschrift.

[41]  R. de Groot,et al.  Streptococcus pneumoniae colonisation: the key to pneumococcal disease. , 2004, The Lancet. Infectious diseases.

[42]  H. Klenk,et al.  Overexpression of the α-2,6-Sialyltransferase in MDCK Cells Increases Influenza Virus Sensitivity to Neuraminidase Inhibitors , 2003, Journal of Virology.

[43]  C. Meyer Germ theory. , 2003, Minnesota medicine.

[44]  W. Gottardi The uptake and release of molecular iodine by the skin: chemical and bactericidal evidence of residual effects caused by povidone-iodine preparations. , 1995, The Journal of hospital infection.

[45]  J. L. Zamora Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions. , 1986, American journal of surgery.

[46]  L. I. Hallay Treatment of influenza. , 1966, Delaware medical journal.

[47]  F. C. Kelly Iodine in Medicine and Pharmacy since its Discovery—1811–1961 , 1961, Proceedings of the Royal Society of Medicine.

[48]  I. Menon,et al.  The 1957 pandemic of influenza in India. , 1959, Bulletin of the World Health Organization.

[49]  F. Burnet,et al.  The action of halogens on influenza virus with special reference to the action of iodine vapour on virus mists. , 1945, The Australian journal of experimental biology and medical science.

[50]  D. Beamish Iodine in the Prophylaxis of Influenza , 1921 .

[51]  J. A. Taylor THE LINGUAL APPLICATION OF IODINE AS A PROPHYLACTIC IN CEREBRO-SPINAL MENINGITIS AND INFLUENZA , 1921, British medical journal.

[52]  David J. Brakenridge,et al.  On Influenza , 1890, Transactions. Medico-Chirurgical Society of Edinburgh.

[53]  Helen Bazile A Dissertation on the Influence of Heat and Humidity; with Practical Observations on the Inhalation of Iodine and Various Vapours in Consumption, Catarrh, Croup, Asthma, and Other Diseases , 1831, Edinburgh medical and surgical journal.