Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase

The amino acid profile and the secretory responses of glutamate dehydrogenase (GDH)-deficient β-cells are characterized. This study shows that GDH is essential for both insulin release and net glutamate synthesis evoked by glucose. Adding cellular glutamate restored the full development of glucose-stimulated insulin secretion, showing the requirement for permissive glutamate levels.

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