Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

[1]  Timothy A. Whitehead,et al.  Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin , 2011, Science.

[2]  D. Eisenberg,et al.  Identifying the amylome, proteins capable of forming amyloid-like fibrils , 2010, Proceedings of the National Academy of Sciences.

[3]  David Eisenberg,et al.  Molecular mechanisms for protein-encoded inheritance , 2009, Nature Structural &Molecular Biology.

[4]  David Eisenberg,et al.  In Brief , 2009, Nature Reviews Neuroscience.

[5]  W. Greene,et al.  The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection , 2008, Journal of Virology.

[6]  J. Agar,et al.  Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth. , 2008, Biochemistry.

[7]  F. Kirchhoff,et al.  Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection , 2007, Cell.

[8]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[9]  Boris Schmidt,et al.  Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. , 2007, Current Alzheimer research.

[10]  Heather T. McFarlane,et al.  Atomic structures of amyloid cross-β spines reveal varied steric zippers , 2007, Nature.

[11]  Atanas V Koulov,et al.  Functional amyloid--from bacteria to humans. , 2007, Trends in biochemical sciences.

[12]  C. Masters,et al.  A primer of amyloid nomenclature , 2007, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[13]  A. Doig,et al.  N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure. , 2006, Biochemistry.

[14]  S. Constantinescu,et al.  Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. , 2006, Biochemistry.

[15]  Barry M Wise,et al.  Prediction of nucleating sequences from amyloidogenic propensities of tau-related peptides. , 2006, Biochemistry.

[16]  D. Baker,et al.  The 3D profile method for identifying fibril-forming segments of proteins. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[17]  B. Reif,et al.  Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils. , 2005, Journal of molecular biology.

[18]  C. Dobson,et al.  Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. , 2005, Biophysical journal.

[19]  Robert A. Grothe,et al.  Structure of the cross-β spine of amyloid-like fibrils , 2005, Nature.

[20]  D. Kirschner,et al.  The Formation of Straight and Twisted Filaments from Short Tau Peptides* , 2004, Journal of Biological Chemistry.

[21]  D. Baker,et al.  Computational redesign of protein-protein interaction specificity , 2004, Nature Structural &Molecular Biology.

[22]  D. Baker,et al.  Design of a Novel Globular Protein Fold with Atomic-Level Accuracy , 2003, Science.

[23]  Bettina Schmitt,et al.  Selection of D‐Amino‐Acid Peptides That Bind to Alzheimer's Disease Amyloid Peptide Aβ1–42 by Mirror Image Phage Display , 2003, Chembiochem : a European journal of chemical biology.

[24]  F. Kirchhoff,et al.  Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism , 2002, Journal of Virology.

[25]  M. Findeis,et al.  Peptide inhibitors of beta amyloid aggregation. , 2002, Current topics in medicinal chemistry.

[26]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[27]  E. Mandelkow,et al.  Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[28]  H. M. Petrassi,et al.  Structure-Based Design of N-Phenyl Phenoxazine Transthyretin Amyloid Fibril Inhibitors , 2000 .

[29]  Klaus Schmidt,et al.  Labelling of peptides with 1.4-nm gold particles to demonstrate their binding sites in the rat spinal cord , 1999, Journal of Neuroscience Methods.

[30]  E. Mandelkow,et al.  A nucleated assembly mechanism of Alzheimer paired helical filaments. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  E. Mandelkow,et al.  Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution. , 1998, Biochemistry.

[32]  B. Chesebro,et al.  Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1 , 1998, Journal of Virology.

[33]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[34]  C. Soto,et al.  Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation. , 1996, Biochemical and biophysical research communications.

[35]  J. Ávila,et al.  Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction , 1996 .

[36]  L. Tjernberg,et al.  Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand (*) , 1996, The Journal of Biological Chemistry.

[37]  E. Mandelkow,et al.  Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[38]  E. Mandelkow,et al.  Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. , 1994, The Journal of biological chemistry.

[39]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[40]  M. Lawrence,et al.  Shape complementarity at protein/protein interfaces. , 1993, Journal of molecular biology.

[41]  G. Drewes,et al.  Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro , 1992, The Journal of cell biology.

[42]  E. Mandelkow,et al.  The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region. , 1992, The EMBO journal.

[43]  A. Garrett,et al.  Ockham’s Razor , 1991 .

[44]  K. Bailey,et al.  The X-ray interpretation of denaturation and the structure of the seed globulins. , 1935, The Biochemical journal.

[45]  K. Sciarretta,et al.  Peptide-based inhibitors of amyloid assembly. , 2006, Methods in enzymology.

[46]  E. Mandelkow,et al.  Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro. , 2005, Methods in molecular biology.

[47]  F. Studier,et al.  Use of T7 RNA polymerase to direct expression of cloned genes. , 1990, Methods in enzymology.