Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
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S. Venkatraman | B. Muñoz | Bowei Wang | Salony Maniar | R. Mumford | R. Lingham | Jasmine Zunic | N. Stock | Joyce P James | K. Alves | Qian Si | K. Treonze | A. Lebsack | M. Gardner