Adjuvant, specific, active immunotherapy for resectable squamous cell lung carcinoma: A 5‐year survival analysis

In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436–466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma‐associated antigen (TAA) and complete Freund's adjuvant (CFA). A phase III study was then designed by the authors to see the effects of specific active immunotherapy compared to the conventional management (no treatment) and to nonspecific immunotherapy.

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