Respiratory effects associated with indoor nitrogen dioxide exposure in children.

BACKGROUND The human health effects of exposure to indoor nitrogen dioxide (NO2) are unclear, and few studies have examined the effects of short-term peak levels of exposure. METHODS The association between indoor exposure to NO2 and respiratory illness was examined in 388 children aged 6-11 years. The NO2 levels were monitored during winter in 41 classrooms, from four schools with unflued gas heating and four schools with electric heating. Each classroom was monitored daily with 6-hour passive diffusion badge monitors over nine alternate weeks, and with hourly monitors over two of those weeks. Children living in homes with unflued gas appliances were also monitored daily over four evenings during times of gas use. RESULTS Exposure to NO2 at hourly peak levels of the order of > or = 80 ppb, compared with background levels of 20 ppb, was associated with a significant increase in sore throat, colds and absences from school. An increase in cough with phlegm was marginally significant. Significant dose-response relationships were demonstrated for these four measures with increasing levels of NO2 exposure. CONCLUSIONS Short-term peak levels of exposure are important to consider in relation to adverse respiratory effects associated with NO2 exposure.

[1]  D. Dockery,et al.  Passive smoking, gas cooking, and respiratory health of children living in six cities. , 2015, The American review of respiratory disease.

[2]  F. Speizer,et al.  Respiratory disease rates and pulmonary function in children associated with NO2 exposure. , 2015, The American review of respiratory disease.

[3]  V. White,et al.  Australian adult smoking prevalence in 1992. , 2010, Australian journal of public health.

[4]  D. Jarvis,et al.  Association of respiratory symptoms and lung function in young adults with use of domestic gas appliances , 1996, The Lancet.

[5]  G. Pershagen,et al.  Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children. , 1995, International journal of epidemiology.

[6]  Rotha.  GENSTAT 5 Release 3 Reference Manual , 1993 .

[7]  J. Samet,et al.  Nitrogen dioxide and respiratory illnesses in infants. , 1993, The American review of respiratory disease.

[8]  N. Breslow,et al.  Approximate inference in generalized linear mixed models , 1993 .

[9]  D. Dockery,et al.  Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children. , 1991, American journal of epidemiology.

[10]  J S Boleij,et al.  Respiratory health effects of the indoor environment in a population of Dutch children. , 1990, The American review of respiratory disease.

[11]  J H Ho,et al.  Personal exposure to nitrogen dioxide and its association with respiratory illness in Hong Kong. , 1990, The American review of respiratory disease.

[12]  J. Samet,et al.  Health effects and sources of indoor air pollution. Part I. , 1987, The American review of respiratory disease.

[13]  C. Florey,et al.  The Tayside infant morbidity and mortality study: effect on health of using gas for cooking. , 1985, British medical journal.

[14]  B D Goldstein,et al.  Childhood respiratory illness and the home environment. II. Association between respiratory illness and nitrogen dioxide, temperature and relative humidity. , 1982, International journal of epidemiology.

[15]  M D Keller,et al.  Respiratory illness in households using gas and electricity for cooking. I. Survey of incidence. , 1979, Environmental research.

[16]  F. J. Miller,et al.  Influence of exposure mode on the toxicity of NO2. , 1979, Environmental health perspectives.

[17]  D G Altman,et al.  Association between gas cooking and respiratory disease in children. , 1977, British medical journal.

[18]  P. Hájek.  On Approximate Inference , 1998 .

[19]  F. J. Miller,et al.  Influence of exposure patterns of nitrogen dioxide and modifications by ozone on susceptibility to bacterial infectious disease in mice. , 1987, Journal of toxicology and environmental health.

[20]  F. J. Miller,et al.  Evaluating the toxicity of urban patterns of oxidant gases. II. Effects in mice from chronic exposure to nitrogen dioxide. , 1987, Journal of toxicology and environmental health.

[21]  B. Brunekreef,et al.  Exposure to nitrogen dioxide and tobacco smoke and respiratory health of children. , 1987 .

[22]  B. Brunekreef,et al.  Indoor nitrogen dioxide pollution and respiratory symptoms of schoolchildren , 1984, International archives of occupational and environmental health.

[23]  F. J. Miller,et al.  Non-Respiratory Function of the Lungs: Host Defenses Against Infection , 1982 .

[24]  S. Chinn,et al.  The relation between respiratory illness in primary schoolchildren and the use of gas for cooking--I. Results from a national survey. , 1979, International journal of epidemiology.

[25]  B D Goldstein,et al.  The relation between respiratory illness in primary schoolchildren and the use of gas for cooking--III. Nitrogen dioxide, respiratory illness and lung infection. , 1979, International journal of epidemiology.