The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53.

[1]  S. Stacey,et al.  Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame , 1995, Journal of virology.

[2]  T. Kessis,et al.  Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro. , 1995, Virology.

[3]  E. Androphy,et al.  The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain. , 1995, Oncogene.

[4]  L. Banks,et al.  HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation. , 1995, Oncogene.

[5]  G. Demers,et al.  The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest , 1994, Journal of virology.

[6]  H. Shirasawa,et al.  Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16. , 1994, Virology.

[7]  M. Lechner,et al.  Inhibition of p53 DNA binding by human papillomavirus E6 proteins , 1994, Journal of virology.

[8]  T. Crook,et al.  Modulation of transcriptional regulatory properties of p53 by HPV E6. , 1994, Oncogene.

[9]  E. Androphy,et al.  Cellular transformation by papilomavirus oncorproteins , 1993 .

[10]  Kathleen R. Cho,et al.  Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[11]  P. Howley,et al.  The transcriptional transactivation function of wild‐type p53 is inhibited by SV40 large T‐antigen and by HPV‐16 E6 oncoprotein. , 1992, The EMBO journal.

[12]  L. Sherman,et al.  Human papillomavirus type 16 expresses a variety of alternatively spliced mRNAs putatively encoding the E2 protein. , 1992, Virology.

[13]  J. Schiller,et al.  Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes , 1992, Journal of virology.

[14]  J. Minna,et al.  Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins , 1992, Journal of virology.

[15]  T. Crook,et al.  Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription. , 1992, The EMBO journal.

[16]  D. Lowy,et al.  Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity , 1992, Journal of virology.

[17]  F. X. Bosch,et al.  Antibodies to HPV-16 E6 and E7 proteins as markers for HPV-16-associated invasive cervical cancer. , 1992, Virology.

[18]  L. Sherman,et al.  Expression and splicing patterns of human papillomavirus type‐16 mrnas in pre‐cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers , 1992, International journal of cancer.

[19]  K. Lin,et al.  An efficient method to purify active eukaryotic proteins from the inclusion bodies in Escherichia coli. , 1991, BioTechniques.

[20]  K. Vousden,et al.  Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation , 1991, Cell.

[21]  M. Kozak.  Structural features in eukaryotic mRNAs that modulate the initiation of translation. , 1991, The Journal of biological chemistry.

[22]  S. Fey,et al.  Human papillomavirus type 18 E6*, E6, and E7 protein synthesis in cell-free translation systems and comparison of E6 and E7 in vitro translation products to proteins immunoprecipitated from human epithelial cells , 1991, Journal of virology.

[23]  D. Lowy,et al.  The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture , 1991, Journal of virology.

[24]  T. Crook,et al.  p53 point mutation in HPV negative human cervical carcinoma cell lines. , 1991, Oncogene.

[25]  Arnold J. Levine,et al.  The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 , 1990, Cell.

[26]  M. Stanley,et al.  Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line. , 1990, Virology.

[27]  B. Vogelstein,et al.  Suppression of human colorectal carcinoma cell growth by wild-type p53. , 1990, Science.

[28]  A. Levine,et al.  Association of human papillomavirus types 16 and 18 E6 proteins with p53. , 1990, Science.

[29]  D. Lowy,et al.  HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. , 1989, The EMBO journal.

[30]  D. Lowy,et al.  Papillomavirus polypeptides E6 and E7 are zinc-binding proteins , 1989, Journal of virology.

[31]  H. Prokoph,et al.  Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms , 1989, Journal of virology.

[32]  L. Banks,et al.  Analysis of human papillomavirus type 16 polypeptides in transformed primary cells. , 1988, Virology.

[33]  A. Schneider-Gädicke,et al.  Identification of the human papillomavirus type 18 E6 and E6 proteins in nuclear protein fractions from human cervical carcinoma cells grown in the nude mouse or in vitro. , 1988, Cancer research.

[34]  H. Shirasawa,et al.  Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas , 1988, Journal of virology.

[35]  D. Lowy,et al.  Identification of the HPV‐16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. , 1987, The EMBO journal.

[36]  T. Oltersdorf,et al.  Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. , 1987, The EMBO journal.

[37]  A. Schneider-Gädicke,et al.  Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. , 1986, The EMBO journal.

[38]  F. Wettstein,et al.  Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Suhai,et al.  Human papillomavirus type 16 DNA sequence. , 1985, Virology.

[40]  Wolfgang Mayer,et al.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells , 1985, Nature.

[41]  F. Studier,et al.  Use of T7 RNA polymerase to direct expression of cloned genes. , 1990, Methods in enzymology.