Combined optical and chemical asynchronous event pixel array

The paper presents the concept, layout and simulation results for a combined chemical and optical 92×92 pixel array designed as a 3.18×3.18mm2 ASIC in standard AMS 0.35μm CMOS technology. The optical pixels employ PN junctions as photodiodes, while the chemical pixels use ISFETs that are pH sensitive with the standard passivation layer of the process. Local light intensity and pH level are encoded using pulse frequency modulation (PFM) and conveyed off-chip using the address event representation (AER) protocol. The chip has been conceived specifically to characterize a light sensitive biomolecular thin film that is in turn intended as a retinal implant for the treatment of end-stage retinal degenerative diseases.