Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

[1]  K. Kaarniranta,et al.  The Aging Stress Response and Its Implication for AMD Pathogenesis , 2020, International journal of molecular sciences.

[2]  Andrew P. Voigt,et al.  Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. , 2020, Microvascular research.

[3]  Da-Zhi Wang,et al.  Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics , 2020, Nature Communications.

[4]  D. Hinton,et al.  The Emerging Role of Senescence in Ocular Disease , 2020, Oxidative medicine and cellular longevity.

[5]  Mei Chen,et al.  A Two-Stage Laser-Induced Mouse Model of Subretinal Fibrosis Secondary to Choroidal Neovascularization , 2020, Translational vision science & technology.

[6]  S. Stewart,et al.  Therapy-induced senescence drives bone loss. , 2020, Cancer research.

[7]  J. Błasiak Senescence in the pathogenesis of age-related macular degeneration , 2020, Cellular and Molecular Life Sciences.

[8]  Shannon M. Conley,et al.  Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions , 2019, GeroScience.

[9]  Todd E. Scheetz,et al.  Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration , 2019, Proceedings of the National Academy of Sciences.

[10]  P. Greengard,et al.  Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. , 2019, Cell stem cell.

[11]  M. Serrano,et al.  The chemistry of senescence , 2019, Nature Reviews Chemistry.

[12]  A. Brunet,et al.  Turning back time with emerging rejuvenation strategies , 2019, Nature Cell Biology.

[13]  Je-Hyun Baek,et al.  Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration , 2018, BMC Ophthalmology.

[14]  D. Baker,et al.  Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline , 2018, Nature.

[15]  Srinivas R. Sadda,et al.  Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials , 2018, JAMA ophthalmology.

[16]  Ronald C Petersen,et al.  Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives. , 2018, The Journal of clinical investigation.

[17]  C. Benz,et al.  Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype , 2018, Scientific Reports.

[18]  J. Buxbaum,et al.  cGAS drives non-canonical inflammasome activation in age-related macular degeneration , 2017, Nature Medicine.

[19]  E. Chew,et al.  Treatment of Geographic Atrophy with Intravitreal Sirolimus: The Age-Related Eye Disease Study 2 Ancillary Study. , 2017, Ophthalmology. Retina.

[20]  Paul Mitchell,et al.  The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration. , 2017, Ophthalmology.

[21]  A. Rodríguez-Baeza,et al.  Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging. , 2017, Investigative ophthalmology & visual science.

[22]  Richard F Spaide,et al.  IMPROVING THE AGE-RELATED MACULAR DEGENERATION CONSTRUCT: A New Classification System. , 2017, Retina.

[23]  J. Elisseeff,et al.  Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment , 2017, Nature Medicine.

[24]  E. Ho,et al.  Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism , 2017, Aging cell.

[25]  B. Kennedy,et al.  Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. , 2017, Cancer discovery.

[26]  K. Freund,et al.  REGRESSION OF TYPE 2 NEOVASCULARIZATION INTO A TYPE 1 PATTERN AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION , 2017, Retina.

[27]  Dong-Eun Kim,et al.  Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress , 2017, Autophagy.

[28]  Frédérick A. Mallette,et al.  Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy , 2016, Science Translational Medicine.

[29]  P. Kapahi,et al.  Simvastatin suppresses breast cancer cell proliferation induced by senescent cells , 2015, Scientific Reports.

[30]  D. Baker,et al.  Cellular senescence in aging and age-related disease: from mechanisms to therapy , 2015, Nature Medicine.

[31]  Mariela C. Marazita,et al.  Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration , 2015, Redox biology.

[32]  M. Jensen,et al.  JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age , 2015, Proceedings of the National Academy of Sciences.

[33]  J. Campisi,et al.  Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing , 2015, Nature Communications.

[34]  B. Edgar,et al.  FUCCI sensors: powerful new tools for analysis of cell proliferation , 2015, Wiley interdisciplinary reviews. Developmental biology.

[35]  U. Schraermeyer,et al.  Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration , 2014, Neurobiology of Aging.

[36]  Emmette R. Hutchison,et al.  Are there roles for brain cell senescence in aging and neurodegenerative disorders? , 2014, Biogerontology.

[37]  T. Valero Mitochondrial biogenesis: pharmacological approaches. , 2014, Current pharmaceutical design.

[38]  N. Eter,et al.  Current knowledge on reticular pseudodrusen in age-related macular degeneration , 2014, British Journal of Ophthalmology.

[39]  P. Mitchell,et al.  Estimated Cases of Blindness and Visual Impairment from Neovascular Age-Related Macular Degeneration Avoided in Australia by Ranibizumab Treatment , 2014, PloS one.

[40]  I. Komuro,et al.  Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage. , 2014, Investigative ophthalmology & visual science.

[41]  D. Lindholm,et al.  Diabetes drugs and neurological disorders: new views and therapeutic possibilities. , 2014, The lancet. Diabetes & endocrinology.

[42]  J. Rakic,et al.  Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice , 2013, Nature Protocols.

[43]  W. Hauswirth,et al.  Retinal angiogenesis suppression through small molecule activation of p53. , 2013, The Journal of clinical investigation.

[44]  V. Mahajan,et al.  Combination therapy for neovascular age-related macular degeneration refractory to anti-vascular endothelial growth factor agents. , 2013, Ophthalmology.

[45]  Kelly J. Morris,et al.  A complex secretory program orchestrated by the inflammasome controls paracrine senescence , 2013, Nature Cell Biology.

[46]  G. Ferbeyre,et al.  Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κB activation , 2013, Aging cell.

[47]  K. Falavarjani,et al.  Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature , 2013, Eye.

[48]  J. Campisi Aging, cellular senescence, and cancer. , 2013, Annual review of physiology.

[49]  R. Sachidanandam,et al.  A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis , 2013, Cell Death and Differentiation.

[50]  M. Pennesi,et al.  Animal models of age related macular degeneration. , 2012, Molecular aspects of medicine.

[51]  W. Hauswirth,et al.  DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 , 2012, Cell.

[52]  M. Kozlowski,et al.  senescence : A key contributor to age-related macular degeneration , 2012 .

[53]  Timothy A. Blenkinsop,et al.  Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. , 2012, Cell stem cell.

[54]  J. Campisi,et al.  p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype , 2011, The EMBO journal.

[55]  R. Braun,et al.  DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration , 2011, Nature.

[56]  L. Bakeeva,et al.  Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats , 2010, Aging.

[57]  S. Schwartz,et al.  Age-related macular degeneration: current and novel therapies. , 2010, Maturitas.

[58]  Frederick L Ferris,et al.  Age-related macular degeneration , 2008, The Lancet.

[59]  K. Hirao,et al.  Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage , 2008, Aging cell.

[60]  F. Mascarelli,et al.  Prematurely senescent ARPE-19 cells display features of age-related macular degeneration. , 2008, Free Radical Biology & Medicine.

[61]  A. Joussen,et al.  Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions , 2007, British Journal of Ophthalmology.

[62]  Don H. Anderson,et al.  Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts , 2006, Annals of medicine.

[63]  R. T. Smith,et al.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[64]  A. Edwards,et al.  Complement Factor H Polymorphism and Age-Related Macular Degeneration , 2005, Science.

[65]  J. Gilbert,et al.  Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration , 2005, Science.

[66]  P. Gouras,et al.  Age-related changes in the basement membrane of the retinal pigment epithelium of Rpe65 −/− and wild-type mice , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[67]  Sander R. Dubovy,et al.  Measurement of TIMP-3 expression and Bruch's membrane thickness in human macula. , 2001, Experimental eye research.

[68]  Robert F. Mullins,et al.  An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration , 2001, Progress in Retinal and Eye Research.

[69]  R Birngruber,et al.  Response of the retinal pigment epithelium to selective photocoagulation. , 1992, Archives of ophthalmology.

[70]  G. Ying,et al.  Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials. , 2017, Ophthalmology.

[71]  W. Hauswirth,et al.  DICER 1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP 3 Inflammasome and MyD 88 , 2012 .

[72]  A. Ramé [Age-related macular degeneration]. , 2006, Revue de l'infirmiere.

[73]  N. Rao,et al.  Scanning and transmission electron microscopic findings during RPE wound healing in vivo , 2004, International Ophthalmology.

[74]  M. Nissen,et al.  Age-Related Macular Degeneration , 2002, Drugs & aging.

[75]  J. Handa,et al.  Senescence-associated beta-galactosidase histochemistry for the primate eye. , 1999, Investigative ophthalmology & visual science.