Distinct profile of HIF1α, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma

The serrated colorectal carcinoma (CRC) as proposed to arise from serrated adenoma (SA) is characterized by upregulation of HIF1α, suppression of PTCH or EphB2, loss of DNA repair proteins, and BRAF mutation. The aim of this study was to evaluate alterations of these candidates involved in the serrated pathway in colorectal polyps.

[1]  P. Conesa‐Zamora,et al.  Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI‐H carcinomas , 2012, International journal of cancer.

[2]  Tsuyoshi Saito,et al.  Clear cell variant of squamous cell carcinoma originating in the esophagus: Report of a case with immunohistochemical and oncogenetic analyses , 2012, Pathology international.

[3]  M. Mäkinen,et al.  Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma , 2011, Histopathology.

[4]  L. Aaltonen,et al.  Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations , 2011, Virchows Archiv.

[5]  D. Chang,et al.  KRAS Mutations in Traditional Serrated Adenomas From Korea Herald an Aggressive Phenotype , 2010, The American journal of surgical pathology.

[6]  M. Pino,et al.  Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. , 2009, Cancer research.

[7]  A. Vincent-Salomon,et al.  High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. , 2009, Cancer research.

[8]  R. Ward,et al.  Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma , 2009, Journal of Clinical Pathology.

[9]  C. Kirkpatrick,et al.  Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression , 2008, BMC Cancer.

[10]  Mari Mino-Kenudson,et al.  Sessile Serrated Adenoma: Challenging Discrimination From Other Serrated Colonic Polyps , 2008, The American journal of surgical pathology.

[11]  Arndt Hartmann,et al.  A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. , 2007, American journal of clinical pathology.

[12]  J. Parfitt,et al.  Survivin and hedgehog protein expression in serrated colorectal polyps: an immunohistochemical study. , 2007, Human pathology.

[13]  M. O'brien,et al.  Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma End Points , 2006, The American journal of surgical pathology.

[14]  Rozemary Karamatic,et al.  High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. , 2006, Gastroenterology.

[15]  E. Montgomery,et al.  Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". , 2006, American journal of clinical pathology.

[16]  H. Clevers,et al.  Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis , 2006, Oncogene.

[17]  J. Jiricny.  The multifaceted mismatch-repair system , 2006, Nature Reviews Molecular Cell Biology.

[18]  J. Jass,et al.  Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a ‘fusion’ pathway to colorectal cancer , 2006, Histopathology.

[19]  Andrew J. Wilson,et al.  Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. , 2005, Cancer research.

[20]  J. Jass,et al.  Demographic and pathological characteristics of serrated polyps of colorectum , 2005, Histopathology.

[21]  T. Pawson,et al.  EphB receptor activity suppresses colorectal cancer progression , 2005, Nature.

[22]  E. J. Lee,et al.  Progressive methylation during the serrated neoplasia pathway of the colorectum , 2005, Modern Pathology.

[23]  A. Oniscu,et al.  Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia , 2004, The Journal of pathology.

[24]  A. C. Williams,et al.  Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment , 2004, International journal of cancer.

[25]  N. Matsubara,et al.  BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum , 2004, Gut.

[26]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[27]  Tsung-Teh Wu,et al.  Frequent CpG island methylation in serrated adenomas of the colorectum. , 2003, The American journal of pathology.

[28]  Jahn M. Nesland,et al.  Morphologic Reappraisal of Serrated Colorectal Polyps , 2003, The American journal of surgical pathology.

[29]  E. Sawyer,et al.  Molecular characteristics of serrated adenomas of the colorectum , 2002, Gut.

[30]  K. Kullander,et al.  Mechanisms and functions of eph and ephrin signalling , 2002, Nature Reviews Molecular Cell Biology.

[31]  J. Malejczyk,et al.  Clinical aspects of disrupted Hedgehog signaling (Review). , 2001, International journal of molecular medicine.

[32]  P. Vihko,et al.  Colorectal carcinoma associated with serrated adenoma – prevalence, histological features, and prognosis , 2001, The Journal of pathology.

[33]  K. Kinzler,et al.  Top-down morphogenesis of colorectal tumors , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[34]  A. Pegg.  Repair of O6-alkylguanine by alkyltransferases , 2000 .

[35]  H. Toda,et al.  Genetic Alterations of Mixed Hyperplastic Adenomatous Polyps in the Colon and Rectum , 1998, Japanese journal of cancer research : Gann.

[36]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[37]  M. Pino,et al.  Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1 α and -2 α in Colon Cancer , 2009 .

[38]  N. Goldstein.  Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. , 2006, American journal of clinical pathology.

[39]  M. Redston,et al.  Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. , 2005, Human pathology.

[40]  A. Pegg.  Repair of O(6)-alkylguanine by alkyltransferases. , 2000, Mutation research.

[41]  L. Aaltonen,et al.  Serrated Carcinomas Form a Subclass of Colorectal Cancer with Distinct Molecular Basis , 2022 .