Modelling of an Interactive Network of Hodgkin-Huxley Neurons

Brain is a highly complex non-linear system, made up of neurons which communicate with each other through neurotransmission. The focus here is to understand and simulate the signal transduction in one of the most important sensory bipolar neurons called olfactory receptor neurons (ORN). The first site of odorant transduction-cilia, house the G-protein signaling cascade that has components that interact with each other to produce the cell output. The work involves modelling of cilia, dendrite and axon of ORN, wherein axon has been modelled using the most biologically plausible Hodgkin and Huxley equations. These ORN outputs are in turn used to drive the next layer of neurons which are connected in Freeman’s topology in an attempt to create a small world network. The complete modelling was done in ‘NEURON’ tool.

[1]  Shingo Mabu,et al.  A Class Identification Method Using Freeman’s Olfactory KIII Model , 2016 .

[2]  M. Blaustein,et al.  Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. , 2007, Cardiovascular & hematological disorders drug targets.

[3]  Paul M. Jenkins,et al.  Olfactory cilia: linking sensory cilia function and human disease. , 2009, Chemical senses.

[4]  J. Reisert,et al.  Adaptation of the odour‐induced response in frog olfactory receptor cells , 1999, The Journal of physiology.

[5]  A. Yew,et al.  Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M. T. Shipley,et al.  The Olfactory System , 2023, Methods in Molecular Biology.

[7]  D. Schild,et al.  Biophysical Properties of Olfactory Receptor Neurones , 1992 .

[8]  J. Reisert,et al.  Calcium, the two-faced messenger of olfactory transduction and adaptation , 2003, Current Opinion in Neurobiology.

[9]  J. Vincent,et al.  Information processing in the mammalian olfactory system. , 2005, Physiological reviews.

[10]  S. Frings,et al.  Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels , 2006, The Journal of general physiology.

[11]  A. Pereda,et al.  Electrical synapses and their functional interactions with chemical synapses , 2014, Nature Reviews Neuroscience.

[12]  Michael L. Hines,et al.  The NEURON Book , 2006 .

[13]  A. Yew,et al.  A Mathematical Model of the Spiking Behavior in Olfactory Receptor Neurons , 2004 .

[14]  K. Mori.  The Olfactory System , 2014, Springer Japan.

[15]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[16]  F. Noé,et al.  Kinetics of ligand-receptor interaction reveals an induced-fit mode of binding in a cyclic nucleotide-activated protein. , 2013, Biophysical journal.

[17]  Guang Li,et al.  A pattern recognition method for electronic noses based on an olfactory neural network , 2007 .

[18]  G. Shepherd,et al.  Imaging Odor-Induced Calcium Transients in Single Olfactory Cilia: Specificity of Activation and Role in Transduction , 1998, The Journal of Neuroscience.

[19]  R. Sunitha,et al.  Analysis of the dynamic behaviour of a single Hodgkin-Huxley neuron model , 2015, 2015 International Conference on Emerging Research in Electronics, Computer Science and Technology (ICERECT).

[20]  J. Reisert,et al.  Responses to prolonged odour stimulation in frog olfactory receptor cells , 2001, The Journal of physiology.

[21]  T. Kurahashi,et al.  Signal Transduction in Vertebrate Olfactory Cilia , 2010 .