Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

[1]  K. Chung,et al.  Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma , 2012, PloS one.

[2]  P. Barnes,et al.  Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation. , 2012, Pulmonary pharmacology & therapeutics.

[3]  S. Johnston,et al.  Asthma exacerbations: Origin, effect, and prevention , 2011, Journal of Allergy and Clinical Immunology.

[4]  L. Pfeffer The role of nuclear factor κB in the interferon response. , 2011, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[5]  B. Zuraw,et al.  Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection. , 2011, American journal of respiratory cell and molecular biology.

[6]  I. Adcock,et al.  Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD). , 2010, Current pharmaceutical design.

[7]  R. Platt,et al.  Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. , 2009, The New England journal of medicine.

[8]  P. Lambert,et al.  Oral prednisolone for preschool children with acute virus-induced wheezing. , 2009, The New England journal of medicine.

[9]  K. Yamamoto,et al.  Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. , 2009, Endocrine reviews.

[10]  J. Saklatvala,et al.  Glucocorticoid Regulation of Mouse and Human Dual Specificity Phosphatase 1 (DUSP1) Genes , 2009, The Journal of Biological Chemistry.

[11]  F. Ducharme,et al.  Oral corticosteroids in children with wheezing. , 2009, The New England journal of medicine.

[12]  A. Walter Oral corticosteroids in children with wheezing. , 2009, The New England journal of medicine.

[13]  Christopher S. Stevenson,et al.  Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. , 2009, American journal of respiratory and critical care medicine.

[14]  S. Johnston,et al.  Role of Xanthine Oxidase Activation and Reduced Glutathione Depletion in Rhinovirus Induction of Inflammation in Respiratory Epithelial Cells* , 2008, Journal of Biological Chemistry.

[15]  J. Lötvall,et al.  Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin‐8 release , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[16]  S. Johnston,et al.  Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production , 2008, Proceedings of the National Academy of Sciences.

[17]  P. Cohen,et al.  The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.

[18]  D. Proud,et al.  Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[19]  S. Johnston,et al.  IFN-γ–induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations , 2007, Journal of Allergy and Clinical Immunology.

[20]  S. Johnston,et al.  Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations. , 2007, Current pharmaceutical design.

[21]  Stephen T Holgate,et al.  Role of deficient type III interferon-λ production in asthma exacerbations , 2006, Nature Medicine.

[22]  M. Moss Asthmatic Bronchial Epithelial Cells Have a Deficient Innate Immune Response to Infection With Rhinovirus , 2006, Pediatrics.

[23]  S. Johnston,et al.  Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia. , 2006, Current medicinal chemistry.

[24]  T. Ferro,et al.  Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[25]  I. Adcock,et al.  New insights into the molecular mechanisms of corticosteroids actions. , 2006, Current drug targets.

[26]  I. Adcock,et al.  Update on glucocorticoid action and resistance. , 2006, The Journal of allergy and clinical immunology.

[27]  S. Johnston,et al.  Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. , 2006, American journal of respiratory cell and molecular biology.

[28]  S. Johnston,et al.  Role of deficient type III interferon-lambda production in asthma exacerbations. , 2006, Nature medicine.

[29]  J. Cidlowski,et al.  Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. , 2005, The New England journal of medicine.

[30]  Z. Szatmáry,et al.  Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen-activated Protein (MAP) Kinase* , 2004, Journal of Biological Chemistry.

[31]  K. Chung,et al.  Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations , 2004, Thorax.

[32]  Tak W. Mak,et al.  Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β , 2004 .

[33]  A. Tattersfield,et al.  Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial , 2004, The Lancet.

[34]  Arthur Christopoulos,et al.  International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology , 2003, Pharmacological Reviews.

[35]  V. Imbert,et al.  AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-α in Jurkat leukemic cells , 2003, Oncogene.

[36]  E. D. de KLERK,et al.  Interleukin‐1β and interleukin‐1ra levels in nasal lavages during experimental rhinovirus infection in asthmatic and non‐asthmatic subjects , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[37]  L. Fabbri,et al.  Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. , 2003, Thorax.

[38]  S. Johnston,et al.  Reducing agents inhibit rhinovirus‐induced up‐regulation of the rhinovirus receptor intercellular adhesion molecule‐1 (ICAM‐1) in respiratory epithelial cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  N. Munshi,et al.  NF-κB as a Therapeutic Target in Multiple Myeloma* , 2002, The Journal of Biological Chemistry.

[40]  Stephen T Holgate,et al.  Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study , 2002, The Lancet.

[41]  O. Kassel,et al.  Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP‐1 , 2001, The EMBO journal.

[42]  E. D. de KLERK,et al.  Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection. , 2001, American journal of respiratory and critical care medicine.

[43]  I. Adcock,et al.  Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  I. Adcock,et al.  Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12 , 2000, Molecular and Cellular Biology.

[45]  J. V. van Krieken,et al.  Experimental rhinovirus 16 infection increases intercellular adhesion molecule‐1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[46]  N. Papadopoulos,et al.  Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promoter activation on respiratory epithelial cells. , 2000, The Journal of allergy and clinical immunology.

[47]  M. Iordanov,et al.  Different Mechanisms of c-Jun NH2-terminal Kinase-1 (JNK1) Activation by Ultraviolet-B Radiation and by Oxidative Stressors* , 1999, The Journal of Biological Chemistry.

[48]  S. Johnston,et al.  Rhinovirus Infection Induces Expression of Its Own Receptor Intercellular Adhesion Molecule 1 (ICAM-1) via Increased NF-κB-mediated Transcription* , 1999, The Journal of Biological Chemistry.

[49]  S. Johnston,et al.  Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium. , 1998, Journal of immunology.

[50]  I. Adcock,et al.  Effect of dexamethasone on interleukin‐1β‐(IL‐1β)‐induced nuclear factor‐κB (NF‐κB) and κB‐dependent transcription in epithelial cells , 1998 .

[51]  S. Logan,et al.  Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[52]  I. Adcock,et al.  Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells. , 1998, European journal of biochemistry.

[53]  J. Cidlowski,et al.  Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. , 1998, Molecular endocrinology.

[54]  S. Holgate,et al.  Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial , 1997, BMJ.

[55]  R. Pauwels,et al.  GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[56]  F. Hayden,et al.  Oral prednisone therapy in experimental rhinovirus infections. , 1996, The Journal of allergy and clinical immunology.

[57]  Stephen T Holgate,et al.  Community study of role of viral infections in exacerbations of asthma in 9-11 year old children , 1995, BMJ.

[58]  P P Humphrey,et al.  International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. , 1994, Pharmacological reviews.

[59]  G. Hensel,et al.  Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor. , 1990, The Journal of biological chemistry.

[60]  E. Lennette,et al.  Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections , 1989 .