Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4

[1]  Christoph Wilhelm,et al.  Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset , 2008, Nature Immunology.

[2]  V. Kuchroo,et al.  IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells , 2008, Nature Immunology.

[3]  B. Lambrecht,et al.  GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells , 2007, PLoS biology.

[4]  F. X. Qin,et al.  Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells , 2007, Proceedings of the National Academy of Sciences.

[5]  R. Noelle,et al.  All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.

[6]  Y. Belkaid,et al.  A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism , 2007, The Journal of experimental medicine.

[7]  Y. Belkaid,et al.  Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid , 2007, The Journal of experimental medicine.

[8]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[9]  Jian-Ping Zuo,et al.  COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-γ and IL-10 production by inhibiting T-bet expression , 2007, Journal of Neuroimmunology.

[10]  Marjolein J. W. de Bruijn,et al.  GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development , 2007, European journal of immunology.

[11]  Simon Heath,et al.  Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4 , 2007, PLoS genetics.

[12]  H. Hammad,et al.  Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells , 2007, The Journal of experimental medicine.

[13]  S. Zheng,et al.  IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 , 2007, The Journal of Immunology.

[14]  P. McGettigan,et al.  Selective COX-2 inhibitors: a promise unfulfilled? , 2007, Gastroenterology.

[15]  Cristina M. Tato,et al.  Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals , 2007, The Journal of experimental medicine.

[16]  G. FitzGerald,et al.  Prostaglandin I2 Analogs Inhibit Proinflammatory Cytokine Production and T Cell Stimulatory Function of Dendritic Cells1 , 2007, The Journal of Immunology.

[17]  R. Xu,et al.  Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. , 2006, Gastroenterology.

[18]  F. Powrie,et al.  Essential role for CD103 in the T cell–mediated regulation of experimental colitis , 2005, The Journal of experimental medicine.

[19]  William W. Agace,et al.  Functional specialization of gut CD103 dendritic cells in the regulation of tissue-selective T cell homing , 2005 .

[20]  Li Zhu,et al.  Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1 , 2005, The Journal of Immunology.

[21]  M. A. Curotto de Lafaille,et al.  Oral tolerance in the absence of naturally occurring Tregs. , 2005, The Journal of clinical investigation.

[22]  M. Huang,et al.  Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. , 2005, Cancer research.

[23]  T. Thepen,et al.  FcγRIIB Regulates Nasal and Oral Tolerance: A Role for Dendritic Cells , 2005, The Journal of Immunology.

[24]  Si-young Song,et al.  Retinoic acid imprints gut-homing specificity on T cells. , 2004, Immunity.

[25]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[26]  J. Samsom,et al.  Early Events in Peripheral Regulatory T Cell Induction via the Nasal Mucosa , 2003, The Journal of Immunology.

[27]  J. Garssen,et al.  Functional CD25– and CD25+ mucosal regulatory T cells are induced in gut‐draining lymphoid tissue within 48 h after oral antigen application , 2003, European journal of immunology.

[28]  J. Samsom,et al.  Nasal tolerance induces antigen-specific CD4+CD25- regulatory T cells that can transfer their regulatory capacity to naive CD4+ T cells. , 2003, International immunology.

[29]  S. Narumiya,et al.  The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. , 2002, The Journal of clinical investigation.

[30]  F. Powrie,et al.  CD4(+) regulatory T cells. , 2001, Current opinion in immunology.

[31]  H. Weiner,et al.  Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells , 2001, Immunological reviews.

[32]  A. Khoruts,et al.  Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen1 , 2001, The Journal of Immunology.

[33]  B. Korelitz,et al.  Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study , 2000, American Journal of Gastroenterology.

[34]  R. Sartor,et al.  Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. , 2000, The Journal of clinical investigation.

[35]  O. Morteau.  COX-2: promoting tolerance , 1999, Nature Medicine.

[36]  R. Lorenz,et al.  Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen , 1999, Nature Medicine.

[37]  M. Fresno,et al.  Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. , 1999, Journal of immunology.

[38]  D. Gilroy,et al.  Inducible cyclooxygenase may have anti-inflammatory properties , 1999, Nature Medicine.

[39]  J. Mcghee,et al.  Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses , 1999, The Journal of experimental medicine.

[40]  R. Mebius,et al.  Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39. , 1999, Journal of immunology.

[41]  E. Mizoguchi,et al.  The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. , 1999, Gastroenterology.

[42]  C. Lawrence,et al.  IL‐4‐regulated enteropathy in an intestinal nematode infection , 1998, European journal of immunology.

[43]  D. Wolvers,et al.  Mucosal tolerance is associated with, but independent of, up‐regulation Th2 responses , 1997, Immunology.

[44]  R. Greene,et al.  TGF-β Modulates the Expression of Retinoic Acid-Induced RAR-β in Primary Cultures of Embryonic Palate Cells , 1995 .

[45]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[46]  E. Worthey,et al.  T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. , 1995, Journal of immunology.

[47]  A. Mowat,et al.  A role for IL‐4 in immunologically mediated enteropathy , 1995, Clinical and experimental immunology.

[48]  H. Weiner,et al.  Oral tolerance , 2011, Immunological reviews.

[49]  A. Macpherson,et al.  Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. , 1993, Gastroenterology.

[50]  H. Kaufmann,et al.  Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. , 1987, Annals of internal medicine.

[51]  T. Thepen,et al.  Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells. , 2005, Journal of immunology.

[52]  R. Lorenz,et al.  Response Directing the Tone of the Intestinal Immune Murine Small Intestine Lamina Propria : Production by Stromal Cells in the 2 E Cyclooxygenase-2-Dependent Prostaglandin Spontaneous and Continuous Stenson , 2001 .

[53]  Alfred D. Eaton,et al.  Oral tolerance. , 2000, American journal of respiratory and critical care medicine.

[54]  R. Greene,et al.  Interactions between the transforming growth factor beta (TGF beta) and retinoic acid signal transduction pathways in murine embryonic palatal cells. , 1994, Differentiation; research in biological diversity.

[55]  M. Sporn,et al.  Transforming growth factor beta. , 1988, Advances in cancer research.