Synthesis of the cyclohexene segment of portimine

[1]  S. Hayashi,et al.  Efficient Access to the Functionalized Bicyclic Pharmacophore of Spirolide C by Using a Selective Diels–Alder Reaction , 2017 .

[2]  P. Taylor,et al.  Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors , 2017, Journal of neurochemistry.

[3]  D. T. Harwood,et al.  The marine cytotoxin portimine is a potent and selective inducer of apoptosis , 2016, Apoptosis.

[4]  M. Brimble,et al.  Cyclic Enecarbamates as Precursors of α,β-Unsaturated Iminium Ions: Reactivity and Synthesis of 6,6-Spirocyclic Ring Systems. , 2016, The Journal of organic chemistry.

[5]  F. Rise,et al.  Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate , 2014 .

[6]  A. Wilkins,et al.  Portimine: a bioactive metabolite from the benthic dinoflagellate Vulcanodinium rugosum , 2013 .

[7]  Z. Moussa,et al.  Total synthesis of the spirocyclic imine marine toxin (-)-gymnodimine and an unnatural C4-epimer. , 2011, Journal of the American Chemical Society.

[8]  C. Fruchart-Gaillard,et al.  Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A. , 2011, Journal of the American Chemical Society.

[9]  Davidr . Evans,et al.  Effect of counterion structure on rates and diastereoselectivities in α,β-unsaturated iminium-ion Diels-Alder reactions. , 2011, Organic letters.

[10]  Stéphanie M. Guéret,et al.  Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides. , 2010, Organic letters.

[11]  F. Rise,et al.  Isolation, structural determination and acute toxicity of pinnatoxins E, F and G. , 2010, Journal of agricultural and food chemistry.

[12]  D. Romo,et al.  Enantioselective total synthesis of the marine toxin (-)-gymnodimine employing a Barbier-type macrocyclization. , 2009, Angewandte Chemie.

[13]  S. Hashimoto,et al.  Total synthesis of pinnatoxin A. , 2008, Angewandte Chemie.

[14]  James D White,et al.  Studies on the synthesis of (-)-gymnodimine. Subunit synthesis and coupling. , 2007, The Journal of organic chemistry.

[15]  R. Reents,et al.  Total synthesis and stereochemistry of pinnatoxins B and C. , 2006, Organic letters.

[16]  Steve Wenglowsky,et al.  Biomimetic macrocycle-forming Diels-Alder reaction of an iminium dienophile: synthetic studies directed toward gymnodimine. , 2005, Organic letters.

[17]  M. Inoue,et al.  A formal total synthesis of (+)-pinnatoxin A. , 2004, Angewandte Chemie.

[18]  M. Brimble,et al.  A double alkylation - ring closing metathesis approach to spiroimines , 2004 .

[19]  C. Miles,et al.  Gymnodimine C, an isomer of gymnodimine B, from Karenia selliformis. , 2003, Journal of agricultural and food chemistry.

[20]  A. Murai,et al.  Asymmetric Construction of the Azaspiro[5.5]undec-8-ene System Towards Gymnodimine Synthesis , 2002 .

[21]  A. Murai,et al.  Asymmetric Construction of the Azaspiro[5.6]dodec-9-ene System in Marine Natural Toxins , 2002 .

[22]  I. Burton,et al.  Assignment of the relative stereochemistry of the spirolides, macrocyclic toxins isolated from shellfish and from the cultured dinoflagellate Alexandrium ostenfeldii , 2001 .

[23]  K. Suenaga,et al.  Structural determination of pteriatoxins A, B and C, extremely potent toxins from the bivalve Pteria penguin , 2001 .

[24]  K. Suenaga,et al.  Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata , 2001 .

[25]  Gene-Hsiang Lee,et al.  Spiro-prorocentrimine, a novel macrocyclic lactone from a benthic Prorocentrum sp. of Taiwan , 2001 .

[26]  A. Cembella,et al.  Characterization of spirolides a, c, and 13-desmethyl c, new marine toxins isolated from toxic plankton and contaminated shellfish. , 2001, Journal of natural products.

[27]  C. Miles,et al.  New analogue of gymnodimine from a Gymnodinium species. , 2000, Journal of agricultural and food chemistry.

[28]  M. Hirama,et al.  Synthetic Study of Pinnatoxin A: Intramolecular Diels-Alder Approach to the AG-ring , 1999 .

[29]  A. Zakarian,et al.  Total synthesis of (+)-pinnatoxin A. , 1998, Journal of the American Chemical Society.

[30]  W. Robinson,et al.  The absolute stereochemistry of the New Zealand shellfish toxin gymnodimine , 1997 .

[31]  R. Bouillon,et al.  The synthesis of CD - ring modified 1α,25-dihydroxy vitamin D analogues: Six-membered D-ring analogues II , 1997 .

[32]  J. Walter,et al.  CHARACTERIZATION OF BIOLOGICALLY INACTIVE SPIROLIDES E AND F : IDENTIFICATION OF THE SPIROLIDE PHARMACOPHORE , 1996 .

[33]  D. Uemura,et al.  Relative stereochemistry of pinnatoxin A, a potent shellfish poison from Pinna muricata , 1996 .

[34]  M. Kuramoto,et al.  Isolation and structure of pinnatoxin D, a new shellfish poison from the okinawan bivalve Pinna muricata , 1996 .

[35]  M. Quilliam,et al.  Spirolides B and D, two novel macrocycles isolated from the digestive glands of shellfish , 1996 .

[36]  M. Satake,et al.  Gymnodimine, a new marine toxin of unprecedented structure isolated from New Zealand oysters and the dinoflagellate, Gymnodinium sp. , 1995 .

[37]  D. Dess,et al.  A useful 12-I-5 triacetoxyperiodinane (the Dess-Martin periodinane) for the selective oxidation of primary or secondary alcohols and a variety of related 12-I-5 species , 1991 .

[38]  M. Hirama,et al.  The 10-membered ring analogs of neocarzinostatin chromophore: design, synthesis and mode of decomposition , 1989 .

[39]  D. Dess,et al.  Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones , 1983 .

[40]  J. Luche,et al.  Lanthanoids in organic synthesis. 6. Reduction of .alpha.-enones by sodium borohydride in the presence of lanthanoid chlorides: synthetic and mechanistic aspects , 1981 .

[41]  A. Mancuso,et al.  Oxidation of long-chain and related alcohols to carbonyls by dimethyl sulfoxide "activated" by oxalyl chloride , 1978 .

[42]  K. Pihlaja,et al.  Stereochemical effects in the EI mass spectra of cis- and trans-fused octa/hexahydro-3,l-benzoxazines and -benzothiazines , 2005 .

[43]  J. Mccauley Kishi's group achieved the total synthesis of pinnatoxin A (3) and ent-3. They reported that only natural pinnatoxin A was toxic , 1998 .

[44]  S. Fukuzawa,et al.  PINNATOXIN A : A TOXIC AMPHOTERIC MACROCYCLE FROM THE OKINAWAN BIVALVE PINNA MURICATA , 1995 .