Relationship of alcohol consumption to changes in HDL‐subfractions

Abstract. Epidemiological studies have consistently shown an apparent protective effect of moderate alcohol consumption on coronary artery disease (CAD). This has been considered to be due to the rise in the high‐density cholesterol lipoprotein (HDL‐cholesterol). Since the response of the HDL‐subfractions to moderate or heavy dose of alcohol is less clear, we now compared the high‐density lipoprotein cholesterol status between groups consuming different amounts of alcohol. In this population‐based survey serum total high‐density lipoprotein cholesterol and its HDL2 and HDL3 subfractions were blindly compared between 264 consecutive middle‐aged men (37 teetotallers, 137 moderate drinkers, 90 heavy drinkers) participating in a voluntary health screening and 104 male alcoholics.

[1]  T. Koivula,et al.  Moderate and heavy alcohol consumption have no favorable effect on lipid values. , 1992, Archives of internal medicine.

[2]  R. Cohen,et al.  Change in alcohol consumption and risk of death from all causes and from ischaemic heart disease. , 1991, BMJ.

[3]  E. Rimm,et al.  Prospective study of alcohol consumption and risk of coronary disease in men , 1991, The Lancet.

[4]  W. Willett,et al.  A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. , 1991, The New England journal of medicine.

[5]  R. Beaglehole,et al.  Alcohol consumption and risk of coronary heart disease. , 1991, BMJ.

[6]  S. Grundy.  Cholesterol and coronary heart disease. Future directions. , 1990, JAMA.

[7]  T. Koivula,et al.  The efficiency of a questionnaire in detecting heavy drinkers. , 1990, British journal of addiction.

[8]  J. Rossouw,et al.  Relationship between high density lipoprotein subfractions and coronary risk factors in a rural white population. , 1990, Arteriosclerosis.

[9]  A. G. Shaper.  Alcohol and mortality: a review of prospective studies. , 1990, British journal of addiction.

[10]  M. Salaspuro,et al.  Comparative value of self-report and blood tests in assessing outcome amongst alcoholics. , 1990, British journal of addiction.

[11]  S M Grundy,et al.  Cholesterol and coronary heart disease. , 1990, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[12]  M. Taskinen,et al.  Comparison of the effects of two different doses of alcohol on serum lipoproteins, HDL‐subfractions and apolipoproteins A‐I and A‐II: a controlled study , 1988, European journal of clinical investigation.

[13]  W. Kannel.  Alcohol and cardiovascular disease , 1988, Proceedings of the Nutrition Society.

[14]  H. Keen,et al.  The relationship of high density lipoprotein subfractions to alcohol consumption, other lifestyle factors, and coronary heart disease. , 1988, Atherosclerosis.

[15]  A. Kimball,et al.  Coronary heart disease mortality and alcohol consumption in Framingham. , 1986, American journal of epidemiology.

[16]  M. Taskinen,et al.  Rapid decrease in high density lipoprotein subfractions and postheparin plasma lipase activities after cessation of chronic alcohol intake. , 1986, Atherosclerosis.

[17]  P. Anderson,et al.  Safe limits of drinking: general practitioners' views. , 1985, British medical journal.

[18]  R. Krauss,et al.  The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions. A controlled study. , 1984, The New England journal of medicine.

[19]  S. Kelsey,et al.  The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study. , 1984, Circulation.

[20]  W. Dixon,et al.  BMDP statistical software , 1983 .

[21]  M. Taskinen,et al.  High density lipoprotein subfractions and postheparin plasma lipases in alcoholic men before and after ethanol withdrawal. , 1982, Metabolism: clinical and experimental.

[22]  E. Trell,et al.  Indicators of alcohol consumption: comparisons between a questionnaire (Mm-MAST), interviews and serum gamma-glutamyl transferase (GGT) in a health survey of middle-aged males. , 1982, British journal of addiction.

[23]  D. Newling,et al.  Clinical significance of serum acid phosphatase as measured by ELISA after treatment of benign prostatic hyperplasia. , 1982, Clinical chemistry.

[24]  J. Albers,et al.  Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. , 1982, Clinical chemistry.

[25]  B. Kapur,et al.  High-density lipoprotein cholesterol in male alcoholics with and without severe liver disease. , 1981, The American journal of medicine.

[26]  U. Goldbourt,et al.  ASSOCIATIONS OF SERUM HIGH DENSITY LIPOPROTEIN AND TOTAL CHOLESTEROL WITH TOTAL, CARDIOVASCULAR, AND CANCER MORTALITY IN A 7-YEAR PROSPECTIVE STUDY OF 10 000 MEN , 1981, The Lancet.

[27]  M. Marmot,et al.  ALCOHOL AND MORTALITY: A U-SHAPED CURVE , 1981, The Lancet.

[28]  R. Froede,et al.  Alcoholism--the second great imitator. An introduction to the problem of alcoholism. , 1980, American journal of clinical pathology.

[29]  W. Kannel,et al.  Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. , 1979, Annals of internal medicine.

[30]  Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. , 1977, The New England journal of medicine.

[31]  W. Castelli,et al.  ALCOHOL AND BLOOD LIPIDS The Cooperative Lipoprotein Phenotyping Study , 1977, The Lancet.

[32]  M C Hjortland,et al.  High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. , 1977, The American journal of medicine.