Brain fatty acid synthase activates PPARα to maintain energy homeostasis
暂无分享,去创建一个
M. Lane | A. Vidal-Puig | Miguel López | D. Wozniak | C. Semenkovich | Yimin Zhu | M. Wolfgang | M. Chakravarthy | T. Coleman | L. Yin | Zhiyuan Hu
[1] J. Manson,et al. Body mass index and mortality in men: evaluating the shape of the association , 2007, International Journal of Obesity.
[2] P. Puigserver,et al. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α , 2006, Proceedings of the National Academy of Sciences.
[3] M. W. Schwartz,et al. Central nervous system control of food intake and body weight , 2006, Nature.
[4] T. Harris,et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. , 2006, The New England journal of medicine.
[5] C. Lelliott,et al. Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA , 2006, Diabetes.
[6] C. Long,et al. The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs. , 2006, American journal of physiology. Heart and circulatory physiology.
[7] A. Pocai,et al. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. , 2006, The Journal of clinical investigation.
[8] Ji-yeon Lee,et al. RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function* , 2006, Journal of Biological Chemistry.
[9] M. Prentki,et al. A Role for Hypothalamic Malonyl-CoA in the Control of Food Intake* , 2005, Journal of Biological Chemistry.
[10] J. Després,et al. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. , 2005, The New England journal of medicine.
[11] M. Lane,et al. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[12] K. Mackie,et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. , 2005, The Journal of clinical investigation.
[13] J. Schneider,et al. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. , 2005, Cell metabolism.
[14] Jimmy D Bell,et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. , 2005, The Journal of clinical investigation.
[15] M. Mcdaniel,et al. Pancreatic β-Cell Lipoprotein Lipase Independently Regulates Islet Glucose Metabolism and Normal Insulin Secretion* , 2005, Journal of Biological Chemistry.
[16] Marc Prentki,et al. Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. , 2005, Diabetes.
[17] S. Moreno,et al. Immunolocalization of peroxisome proliferator-activated receptors and retinoid x receptors in the adult rat CNS , 2004, Neuroscience.
[18] Maureen P. Boyle,et al. Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults , 2004, Neurobiology of Disease.
[19] Xueying Lin,et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. , 2004, The Journal of clinical investigation.
[20] C. Bogardus,et al. A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. , 2004, Diabetes.
[21] B. Cha,et al. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. , 2004, The Biochemical journal.
[22] J. Richardson,et al. Essential Role of STAT3 in Body Weight and Glucose Homeostasis , 2004, Molecular and Cellular Biology.
[23] S. Woods,et al. Monitoring of stored and available fuel by the CNS: implications for obesity , 2003, Nature Reviews Neuroscience.
[24] M. Lane,et al. Hypothalamic malonyl-CoA as a mediator of feeding behavior , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[25] S. Gaetani,et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α , 2003, Nature.
[26] Roberto Conti,et al. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production , 2003, Nature Medicine.
[27] S. Chirala,et al. Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[28] S. Woods,et al. C75 inhibits food intake by increasing CNS glucose metabolism , 2003, Nature Medicine.
[29] C. Townsend,et al. Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. , 2002, American journal of physiology. Endocrinology and metabolism.
[30] D. Mangelsdorf,et al. PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[31] D. Macneil,et al. Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice , 2002, Molecular and Cellular Biology.
[32] Yue Feng,et al. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[33] Zhaohui Feng,et al. Central administration of oleic acid inhibits glucose production and food intake. , 2002, Diabetes.
[34] R. Rimondini,et al. Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test , 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[35] H. Fukuda,et al. Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats. , 2001, European journal of biochemistry.
[36] M. Permutt,et al. Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia , 2001 .
[37] C. Semenkovich,et al. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. , 2001, The Journal of clinical investigation.
[38] C. Bouchard. Inhibition of food intake by inhibitors of fatty acid synthase. , 2000, The New England journal of medicine.
[39] C. Townsend,et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. , 2000, Science.
[40] M. Magnuson,et al. Analysis of the Cre‐mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas , 2000, Genesis.
[41] M. Fujimiya,et al. Intracerebroventricularly administered corticotropin‐releasing factor inhibits food intake and produces anxiety‐like behaviour at very low doses in mice , 1999, Diabetes, obesity & metabolism.
[42] M. Magnuson,et al. Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.
[43] B. Lowell,et al. Mice lacking melanin-concentrating hormone are hypophagic and lean , 1998, Nature.
[44] L A Herzenberg,et al. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[45] C. Semenkovich,et al. Regulation of fatty acid synthase (FAS). , 1997, Progress in lipid research.
[46] G. Pasternack,et al. Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. , 1996, Cancer research.
[47] M. Prentki,et al. Evidence for an Anaplerotic/Malonyl-CoA Pathway in Pancreatic β-Cell Nutrient Signaling , 1996, Diabetes.
[48] S. Dudek,et al. Essential Amino Acids Regulate Fatty Acid Synthase Expression through an Uncharged Transfer RNA-dependent Mechanism* , 1995, The Journal of Biological Chemistry.
[49] C. Semenkovich,et al. Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability. , 1993, Journal of Biological Chemistry.
[50] S. Woods,et al. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons , 1979, Nature.
[51] R. Ockner,et al. Inhibition of rat liver acetyl coenzyme A carboxylase by long chain acyl coenzyme A and fatty acid. Modulation by fatty acid-binding protein. , 1977, The Journal of biological chemistry.
[52] Joan,et al. Inhibition of Rat Liver Acetyl Coenzyme A Carboxylase by Long Chain Acyl Coenzyme A and Fatty Acid , 2002 .
[53] N. Wong,et al. Fatty acid synthase and adipsin mRNA levels in obese and lean JCR:LA-cp rats: effect of diet. , 1992, Journal of lipid research.