Chapter 1 – Molecular Determinants of Lung Morphogenesis

[1]  I. Lohmann,et al.  Shaping segments: Hox gene function in the genomic age , 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

[2]  E. Veldhuizen,et al.  Surfactant Collectins and Innate Immunity , 2008, Neonatology.

[3]  Yun Lu,et al.  Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. , 2008, Proceedings of the American Thoracic Society.

[4]  J. Whitsett,et al.  R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis , 2008, Development.

[5]  Rudolf Jaenisch,et al.  Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters , 2008, Cell.

[6]  Derek Y. Chiang,et al.  Characterizing the cancer genome in lung adenocarcinoma , 2007, Nature.

[7]  J. M. Thomson,et al.  Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. , 2007, Developmental biology.

[8]  G. Deutsch,et al.  Key Mechanisms of Early Lung Development , 2007, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[9]  B. Hogan,et al.  Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm , 2007, Development.

[10]  J. Whitsett,et al.  Expression of ABCA3 in Developing Lung and Other Tissues , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[11]  C. Galambos,et al.  Molecular Mechanisms of Pulmonary Vascular Development , 2007, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[12]  J. Klingensmith,et al.  Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. , 2006, Differentiation; research in biological diversity.

[13]  T. Svingen,et al.  Hox transcription factors and their elusive mammalian gene targets , 2006, Heredity.

[14]  A. Perl,et al.  Erm/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription* , 2006, Journal of Biological Chemistry.

[15]  P. Burri,et al.  Structural Aspects of Postnatal Lung Development – Alveolar Formation and Growth , 2006, Neonatology.

[16]  J. Whitsett,et al.  In defense of the lung: surfactant protein A and surfactant protein D. , 2006, Current opinion in pharmacology.

[17]  J. Lü,et al.  Regulation of early lung morphogenesis: questions, facts and controversies , 2006, Development.

[18]  Y. Marikawa.  Wnt/β-catenin signaling and body plan formation in mouse embryos , 2006 .

[19]  T. Mäkinen,et al.  Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling. , 2006, Experimental cell research.

[20]  Michael T. McManus,et al.  Dicer function is essential for lung epithelium morphogenesis , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. van Nes,et al.  Developmental regulation of the Hox genes during axial morphogenesis in the mouse , 2005, Development.

[22]  Donald E Ingber,et al.  Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[23]  J. L. Yntema,et al.  Brain-Thyroid-Lung syndrome: a patient with a severe multi-system disorder due to a de novo mutation in the thyroid transcription factor 1 gene , 2005, European Journal of Pediatrics.

[24]  H. Duncker.  Vertebrate lungs: structure, topography and mechanics A comparative perspective of the progressive integration of respiratory system, locomotor apparatus and ontogenetic development , 2004, Respiratory Physiology & Neurobiology.

[25]  B. Bejjani,et al.  Expanding the phenotype of alveolar capillary dysplasia (ACD). , 2004, The Journal of pediatrics.

[26]  Jeffrey A Whitsett,et al.  Foxa2 is required for transition to air breathing at birth. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Jeffrey A. Whitsett,et al.  Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells* , 2004, Journal of Biological Chemistry.

[28]  M. Scavina,et al.  Autosomal dominant transmission of congenital hypothyroidism, neonatal respiratory distress, and ataxia caused by a mutation of NKX2-1. , 2004, The Journal of pediatrics.

[29]  A. Zorn,et al.  Sox17 and β-catenin cooperate to regulate the transcription of endodermal genes , 2004 .

[30]  M. Yaffe,et al.  TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C* , 2004, Journal of Biological Chemistry.

[31]  A. Jobe,et al.  Choice and dose of corticosteroid for antenatal treatments. , 2004, American journal of obstetrics and gynecology.

[32]  K. Kaestner,et al.  Foxa2 regulates alveolarization and goblet cell hyperplasia , 2004, Development.

[33]  J. Shannon,et al.  Epithelial-mesenchymal interactions in the developing lung. , 2004, Annual review of physiology.

[34]  R. Gronostajski,et al.  Nuclear Factor I/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription , 2003, Molecular and Cellular Biology.

[35]  J. C. Hombría,et al.  Beyond homeosis--HOX function in morphogenesis and organogenesis. , 2003, Differentiation; research in biological diversity.

[36]  Susan E Wert,et al.  TTF-1 Phosphorylation Is Required for Peripheral Lung Morphogenesis, Perinatal Survival, and Tissue-specific Gene Expression* , 2003, Journal of Biological Chemistry.

[37]  F. Goodman.  Congenital abnormalities of body patterning: embryology revisited , 2003, The Lancet.

[38]  R. Strieter,et al.  Host innate defenses in the lung: the role of cytokines , 2003, Current opinion in infectious diseases.

[39]  V. Boggaram.  Regulation of lung surfactant protein gene expression. , 2003, Frontiers in bioscience : a journal and virtual library.

[40]  A. Jobe.  Antenatal factors and the development of bronchopulmonary dysplasia. , 2003, Seminars in neonatology : SN.

[41]  J. Maina,et al.  Structure, function and evolution of the gas exchangers: comparative perspectives , 2002, Journal of anatomy.

[42]  A. Offiah,et al.  The phenotype of survivors of campomelic dysplasia , 2002, Journal of medical genetics.

[43]  E. Morrisey,et al.  The WNT7b Promoter Is Regulated by TTF-1, GATA6, and Foxa2 in Lung Epithelium* , 2002, The Journal of Biological Chemistry.

[44]  Donald E Ingber,et al.  Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. , 2002, The Journal of surgical research.

[45]  J. Whitsett,et al.  GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression* , 2002, The Journal of Biological Chemistry.

[46]  E. Zackai,et al.  Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. , 2002, American journal of human genetics.

[47]  H. Delemarre-van de Waal,et al.  Glucocorticoids and lung development in the fetus and preterm infant , 2001, Pediatric pulmonology.

[48]  M. Nord,et al.  Regulation of the Clara Cell Secretory Protein/Uteroglobin Promoter in Lung , 2000, Annals of the New York Academy of Sciences.

[49]  D. Demello,et al.  Embryonic and Early Fetal Development of Human Lung Vasculature and Its Functional Implications , 2000, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[50]  K. Devriendt,et al.  Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure. , 2000, The Journal of pediatrics.

[51]  E. Henske,et al.  Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Tichelaar,et al.  Conditional Expression of Fibroblast Growth Factor-7 in the Developing and Mature Lung* , 2000, The Journal of Biological Chemistry.

[53]  W. Birchmeier,et al.  Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice , 2000, The Journal of cell biology.

[54]  W. McGinnis,et al.  Developmental patterning genes and their conserved functions: from model organisms to humans. , 2000, Molecular genetics and metabolism.

[55]  P. Minoo,et al.  Inhibition of distal lung morphogenesis in Nkx2.1(−/−) embryos , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[56]  J. Whitsett,et al.  Retinoic Acid Stimulation of the Human Surfactant Protein B Promoter Is Thyroid Transcription Factor 1 Site-dependent* , 2000, The Journal of Biological Chemistry.

[57]  P. Minoo,et al.  Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. , 1999, Developmental biology.

[58]  P. Minoo,et al.  Thyroid-specific enhancer-binding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia. , 1999, Biochimie.

[59]  J. Bourbon,et al.  Keratinocyte growth factor enhances maturation of fetal rat lung type II cells. , 1999, American journal of respiratory cell and molecular biology.

[60]  J. Whitsett,et al.  Regulation of surfactant protein gene transcription. , 1998, Biochimica et biophysica acta.

[61]  E. Morrisey,et al.  GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. , 1998, Genes & development.

[62]  D. Danilenko,et al.  Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. , 1998, Genes & development.

[63]  A. McMahon,et al.  Sonic hedgehog regulates branching morphogenesis in the mammalian lung , 1998, Current Biology.

[64]  K. Devriendt,et al.  Deletion of thyroid transcription factor-1 gene in an infant with neonatal thyroid dysfunction and respiratory failure. , 1998, The New England journal of medicine.

[65]  J. Heath,et al.  Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[66]  W. McGinnis,et al.  Shaping animal body plans in development and evolution by modulation of Hox expression patterns , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[67]  B. Stripp,et al.  Epithelial‐mesenchymal interactions in the alteration of gene expression and morphology following lung injury , 1997, Microscopy research and technique.

[68]  J. Brody,et al.  FGF‐1 and FGF‐7 induce distinct patterns of growth and differentiation in embryonic lung epithelium , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[69]  B. Stripp,et al.  Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1. , 1997, Biochimica et biophysica acta.

[70]  P. Dollé,et al.  Developmental functions of mammalian Hox genes. , 1997, Molecular human reproduction.

[71]  L. Lim,et al.  Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. , 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[72]  C. Wilson,et al.  Expression of Hoxb genes in the developing mouse foregut and lung. , 1996, American journal of respiratory cell and molecular biology.

[73]  J. Whitsett,et al.  Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. , 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[74]  J. Whitsett,et al.  Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells , 1996, Molecular and cellular biology.

[75]  C. Betsholtz,et al.  PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis , 1996, Cell.

[76]  C. Bingle,et al.  The lung enriched transcription factor TTF-1 and the ubiquitously expressed proteins Sp1 and Sp3 interact with elements located in the minimal promoter of the rat Clara cell secretory protein gene. , 1996, The Biochemical journal.

[77]  J. Whitsett,et al.  ACINAR DYSPLASIA IS ASSOCIATED WITH THE ABSENCE OF TTF-1 AND HNF-3β EXPRESSION DURING HUMAN LUNG DEVELOPMENT. † 2117 , 1996, Pediatric Research.

[78]  S. E. Kelly,et al.  Transcription of the Lung-specific Surfactant Protein C Gene Is Mediated by Thyroid Transcription Factor 1 (*) , 1996, The Journal of Biological Chemistry.

[79]  G. Dranoff,et al.  Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. , 1996, The Journal of clinical investigation.

[80]  J. Whitsett,et al.  Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[81]  G. Breier,et al.  Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[82]  J. Whitsett,et al.  Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1 (*) , 1995, The Journal of Biological Chemistry.

[83]  M. Pembrey,et al.  A clinical and genetic study of campomelic dysplasia. , 1995, Journal of medical genetics.

[84]  J. Whitsett,et al.  Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells (*) , 1995, The Journal of Biological Chemistry.

[85]  J. Whitsett,et al.  Lung Cell-specific Expression of the Murine Surfactant Protein A (SP-A) Gene Is Mediated by Interactions between the SP-A Promoter and Thyroid Transcription Factor-1 (*) , 1995, The Journal of Biological Chemistry.

[86]  N. Tommerup,et al.  Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9 , 1994, Cell.

[87]  Sahar Mansour,et al.  Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene , 1994, Nature.

[88]  R. Costa,et al.  Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. , 1994, Developmental biology.

[89]  R. Lauro,et al.  The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis , 1994, Molecular and cellular biology.

[90]  J. Whitsett,et al.  Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung. , 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[91]  Thomas M. Jessell,et al.  The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo , 1994, Cell.

[92]  J. Rossant,et al.  HNF-3β is essential for node and notochord formation in mouse development , 1994, Cell.

[93]  A. Dunn,et al.  Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[94]  C. Kenyon,et al.  Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations. , 1994, Trends in genetics : TIG.

[95]  G. Dranoff,et al.  Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. , 1994, Science.

[96]  K. Longmuir,et al.  Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. , 1994, The Journal of clinical investigation.

[97]  B. Hogan,et al.  HNF-3β as a regulator of floor plate development , 1994, Cell.

[98]  A. T. Have-Opbroek,et al.  Clara cell differentiation in the mouse : ultrastructural morphology and cytochemistry for surfactant protein A and clara cell 10 kD protein , 1993 .

[99]  J. Botas.  Control of morphogenesis and differentiation by HOM/Hox genes. , 1993, Current opinion in cell biology.

[100]  J. Pilewski,et al.  Adhesion molecules in the lung. An overview. , 1993, The American review of respiratory disease.

[101]  L. Williams,et al.  Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[102]  J. Gitlin,et al.  Identification of hepatocyte nuclear factor-3 binding sites in the Clara cell secretory protein gene. , 1993, The Biochemical journal.

[103]  J. Whitsett,et al.  Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[104]  B. Stripp,et al.  The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families , 1993, Molecular and cellular biology.

[105]  E. Lai,et al.  Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[106]  A. Ullrich,et al.  High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis , 1993, Cell.

[107]  A. Tanswell,et al.  Expression of Basic Fibroblast Growth Factor and Receptor: Immunolocalization Studies in Developing Rat Fetal Lung , 1992, Pediatric Research.

[108]  A. Persson,et al.  Developmental expression of pulmonary surfactant protein D (SP-D). , 1991, American journal of respiratory cell and molecular biology.

[109]  H. Endo,et al.  An immunohistochemical study of bronchial cells producing surfactant protein A in the developing human fetal lung. , 1991, Early human development.

[110]  N. Hooper,et al.  Function and regulation of expression of pulmonary surfactant-associated proteins. , 1991, The Biochemical journal.

[111]  K. Leslie,et al.  Alpha smooth muscle actin expression in developing and adult human lung. , 1990, Differentiation; research in biological diversity.

[112]  J. Strum,et al.  Immunochemical localization of Clara cell protein by light and electron microscopy in conducting airways of fetal and neonatal hamster lung , 1990, The Anatomical record.

[113]  J. Shannon,et al.  Ontogeny of Surfactant Apoproteins in the Rat , 1989, Pediatric Research.

[114]  P. Ballard,et al.  Hormonal regulation of pulmonary surfactant. , 1989, Endocrine reviews.

[115]  S. Katyal,et al.  Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein. , 1988, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[116]  J. Shannon,et al.  Functional differentiation of alveolar type II epithelial cells in vitro: effects of cell shape, cell-matrix interactions and cell-cell interactions. , 1987, Biochimica et biophysica acta.

[117]  J. Opitz,et al.  The campomelic syndrome: review, report of 17 cases, and follow-up on the currently 17-year-old boy first reported by Maroteaux et al in 1971. , 1983, American journal of medical genetics.

[118]  Jeffrey A Whitsett,et al.  Transcriptional control of lung morphogenesis. , 2007, Physiological reviews.

[119]  D. Warburton,et al.  The molecular genetics of lung morphogenesis and injury repair. , 2004, Paediatric respiratory reviews.

[120]  C. Meischl,et al.  The molecular basis of chronic granulomatous disease , 2004, Springer Seminars in Immunopathology.

[121]  D. Grier,et al.  Effects of Glucocorticoids on Fetal and Neonatal Lung Development , 2004, Treatments in respiratory medicine.

[122]  G. K. Davis,et al.  Short, long, and beyond: molecular and embryological approaches to insect segmentation. , 2002, Annual review of entomology.

[123]  O. Hino,et al.  Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis , 2002, Journal of Human Genetics.

[124]  Nobuyuki Itoh,et al.  Fgf10 is essential for limb and lung formation , 1999, Nature Genetics.

[125]  M. Weichselbaum,et al.  The Development of the innervation and the airway smooth muscle in the human fetal lung , 1998 .

[126]  L. Honigberg,et al.  The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans. , 1997, Cold Spring Harbor symposia on quantitative biology.

[127]  P. Sannes,et al.  Basement membranes and pulmonary development. , 1997, Experimental lung research.

[128]  T. Lufkin.  Transcriptional regulation of vertebrate Hox genes during embryogenesis. , 1997, Critical reviews in eukaryotic gene expression.

[129]  S. R. Hilfer,et al.  Morphogenesis of the lung: control of embryonic and fetal branching. , 1996, Annual review of physiology.

[130]  C H Fox,et al.  The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. , 1996, Genes & development.

[131]  E. Chi.  The ultrastructural study of glycogen and lamellar bodies in the development of fetal monkey lung. , 1985, Experimental lung research.