An updated assessment of microglia depletion: current concepts and future directions

[1]  D. Gomez-Nicola,et al.  A story of birth and death: Insights into the formation and dynamics of the microglial population , 2017, Brain, Behavior, and Immunity.

[2]  C. Putterman,et al.  CSF-1R inhibition attenuates renal and neuropsychiatric disease in murine lupus. , 2017, Clinical immunology.

[3]  J. Delpech,et al.  Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[4]  A. Najafi,et al.  Microglial repopulation resolves inflammation and promotes brain recovery after injury , 2017, Glia.

[5]  M. Colonna,et al.  Microglia Function in the Central Nervous System During Health and Neurodegeneration. , 2017, Annual review of immunology.

[6]  Hailin Zhao,et al.  The role of microglia in the pathobiology of neuropathic pain development: what do we know? , 2017, British journal of anaesthesia.

[7]  M. Prinz,et al.  Ontogeny and homeostasis of CNS myeloid cells , 2017, Nature Immunology.

[8]  A. Michelucci,et al.  Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population , 2017, Front. Immunol..

[9]  A. ElAli,et al.  Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions , 2017, International journal of molecular sciences.

[10]  S. Tsirka,et al.  International Journal of Molecular Sciences the Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (cns) Autoimmunity , 2022 .

[11]  H. Kettenmann,et al.  Microglia in Physiology and Disease. , 2017, Annual review of physiology.

[12]  E. Audinat,et al.  Microglia in CNS development: Shaping the brain for the future , 2017, Progress in Neurobiology.

[13]  Sarah Jäkel,et al.  Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation , 2017, Front. Cell. Neurosci..

[14]  O. Garaschuk,et al.  Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain , 2017, Cell reports.

[15]  Kathryn M. Lenz,et al.  Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female rats , 2017, Behavioural Brain Research.

[16]  Minshu Li,et al.  Depletion of microglia exacerbates postischemic inflammation and brain injury , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  Ukpong B. Eyo,et al.  Microglia–Neuron Communication in Epilepsy , 2017, Glia.

[18]  F. Shi,et al.  Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  L. Du,et al.  Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target , 2017, Molecular Neurobiology.

[20]  P. Pelegrín,et al.  M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b , 2016, Mediators of inflammation.

[21]  N. Mahy,et al.  Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited. , 2016, Current medicinal chemistry.

[22]  Paul J. Lucassen,et al.  The Indispensable Roles of Microglia and Astrocytes during Brain Development , 2016, Front. Hum. Neurosci..

[23]  M. McCarthy,et al.  Temporary Depletion of Microglia during the Early Postnatal Period Induces Lasting Sex-Dependent and Sex-Independent Effects on Behavior in Rats , 2016, eNeuro.

[24]  H. Kettenmann,et al.  The “Big‐Bang” for modern glial biology: Translation and comments on Pío del Río‐Hortega 1919 series of papers on microglia , 2016, Glia.

[25]  B. Stevens,et al.  Increasing the neurological-disease toolbox using iPSC-derived microglia , 2016, Nature Medicine.

[26]  B. Becher,et al.  Sall1 is a transcriptional regulator defining microglia identity and function , 2016, Nature Immunology.

[27]  T. Malm,et al.  Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets , 2016, Journal of Molecular Neuroscience.

[28]  W. Le,et al.  Protective Microglia and Their Regulation in Parkinson’s Disease , 2016, Front. Mol. Neurosci..

[29]  Li-Huei Tsai,et al.  Efficient derivation of microglia-like cells from human pluripotent stem cells , 2016, Nature Medicine.

[30]  J. Baulch,et al.  Elimination of microglia improves cognitive function following cranial irradiation , 2016, Scientific Reports.

[31]  Tuan Leng Tay,et al.  The force awakens: insights into the origin and formation of microglia , 2016, Current Opinion in Neurobiology.

[32]  D. Schafer,et al.  Microglia: Architects of the Developing Nervous System. , 2016, Trends in cell biology.

[33]  K. Ji,et al.  Dynamic microglial modulation of spatial learning and social behavior , 2016, Brain, Behavior, and Immunity.

[34]  W. Gan,et al.  Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury , 2016, Nature Communications.

[35]  G. Katona,et al.  Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke , 2016, Nature Communications.

[36]  Toshihide Yamashita,et al.  Microglia in central nervous system repair after injury. , 2016, Journal of biochemistry.

[37]  A. Najafi,et al.  Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. , 2016, Brain : a journal of neurology.

[38]  R. Ransohoff,et al.  Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling. , 2016, Immunity.

[39]  T. Jin,et al.  Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models , 2016, Mediators of inflammation.

[40]  Y. de Koninck,et al.  Dynamics of spinal microglia repopulation following an acute depletion , 2016, Scientific Reports.

[41]  M. Prinz,et al.  Genetic manipulation of microglia during brain development and disease. , 2016, Biochimica et biophysica acta.

[42]  F. C. Bennett,et al.  New tools for studying microglia in the mouse and human CNS , 2016, Proceedings of the National Academy of Sciences.

[43]  M. Prinz,et al.  Microglia: A Unique Versatile Cell in the Central Nervous System. , 2016, ACS chemical neuroscience.

[44]  B. Stevens,et al.  New insights on the role of microglia in synaptic pruning in health and disease , 2016, Current Opinion in Neurobiology.

[45]  Yuko Saito,et al.  TMEM119 marks a subset of microglia in the human brain , 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

[46]  T. Möller,et al.  Central nervous system myeloid cells as drug targets: current status and translational challenges , 2015, Nature Reviews Drug Discovery.

[47]  Helmut Kettenmann,et al.  The role of microglia and macrophages in glioma maintenance and progression , 2015, Nature Neuroscience.

[48]  F. Ginhoux,et al.  Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems. , 2015, Trends in immunology.

[49]  Steffen Jung,et al.  Microglia Plasticity During Health and Disease: An Immunological Perspective. , 2015, Trends in immunology.

[50]  B. Stevens,et al.  Microglia Function in Central Nervous System Development and Plasticity. , 2015, Cold Spring Harbor perspectives in biology.

[51]  K. Ley,et al.  Macrophage Polarization: Decisions That Affect Health , 2015, Journal of clinical & cellular immunology.

[52]  J. Qu,et al.  Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish. , 2015, Developmental cell.

[53]  Jianpeng Sheng,et al.  Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells. , 2015, Immunity.

[54]  B. Stevens,et al.  Microglia function during brain development: New insights from animal models , 2015, Brain Research.

[55]  Frauke Zipp,et al.  Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. , 2015, Immunity.

[56]  F. Ginhoux,et al.  Origin of microglia: current concepts and past controversies. , 2015, Cold Spring Harbor perspectives in biology.

[57]  A. Bar-Or,et al.  Roles of microglia in brain development, tissue maintenance and repair. , 2015, Brain : a journal of neurology.

[58]  K. Green,et al.  Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation , 2015, PloS one.

[59]  K. Knobeloch,et al.  Genetic targeting of microglia , 2015, Glia.

[60]  F. Geissmann,et al.  Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors , 2014, Nature.

[61]  W. Le,et al.  Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases , 2016, Molecular Neurobiology.

[62]  Robert A. Harris.  Spatial, Temporal, and Functional Aspects of Macrophages during “The Good, the Bad, and the Ugly” Phases of Inflammation , 2014, Front. Immunol..

[63]  Maria Nikodemova,et al.  CSF1 overexpression has pleiotropic effects on microglia in vivo , 2014, Glia.

[64]  D. Brody,et al.  Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury. , 2014, Journal of neurotrauma.

[65]  F. Rossi,et al.  The role of microglia in human disease: therapeutic tool or target? , 2014, Acta Neuropathologica.

[66]  J. Kipnis,et al.  Microglia as a critical player in both developmental and late-life CNS pathologies , 2014, Acta Neuropathologica.

[67]  P. Stinissen,et al.  Macrophage subsets and microglia in multiple sclerosis , 2014, Acta Neuropathologica.

[68]  V. Malmström,et al.  An optimized Protocol for Human M2 Macrophages using M-CSF and IL-4/IL-10/TGF-β Yields a Dominant Immunosuppressive Phenotype , 2014, Scandinavian journal of immunology.

[69]  Brian L. West,et al.  Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain , 2014, Neuron.

[70]  D. Bergles,et al.  Hidden Progenitors Replace Microglia in the Adult Brain , 2014, Neuron.

[71]  R. Glass,et al.  CNS macrophages and peripheral myeloid cells in brain tumours , 2014, Acta Neuropathologica.

[72]  Marco Prinz,et al.  Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease , 2014, Nature Reviews Neuroscience.

[73]  R. Harris,et al.  Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice , 2014, Glia.

[74]  S. Gygi,et al.  Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia , 2013, Nature Neuroscience.

[75]  J. Yates,et al.  Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor , 2013, Cell.

[76]  E. Benarroch.  Microglia , 2013, Neurology.

[77]  Ukpong B. Eyo,et al.  Bidirectional Microglia-Neuron Communication in the Healthy Brain , 2013, Neural plasticity.

[78]  F. Kirchhoff,et al.  Microglia: New Roles for the Synaptic Stripper , 2013, Neuron.

[79]  O. Garaschuk,et al.  Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells , 2012, Proceedings of the National Academy of Sciences.

[80]  O. Crespo,et al.  Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis , 2011, Journal of Clinical Immunology.

[81]  F. Ginhoux,et al.  Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages , 2010, Science.

[82]  A. Surprenant,et al.  Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates , 2009, The EMBO journal.

[83]  W. Robberecht,et al.  Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase , 2008, The Journal of Neuroscience.

[84]  A. Mildner,et al.  Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions , 2007, Nature Neuroscience.

[85]  J. Julien,et al.  Mouse model for ablation of proliferating microgliain acute CNS injuries , 2006, Glia.

[86]  B. Becher,et al.  Experimental autoimmune encephalomyelitis repressed by microglial paralysis (vol 11, pg 146, 2005) , 2005 .

[87]  B. Becher,et al.  Experimental autoimmune encephalomyelitis repressed by microglial paralysis , 2005, Nature Medicine.

[88]  R. Baler,et al.  Genetic Targeting , 1999, Journal of neurochemistry.