Improved holder for intrinsic dissolution rate studies.

An improved holder for use in rotational disk dissolution studies has been developed. The compression die becomes the rotating member. With it, the relative intrinsic dissolution rates at 37° in 0.1 N HC1 with 430 r.p.m. rotational speed have been found to be caffeine monohydrate, 106, aspirin, 9.73, salicylamide, 12.3, and acetaminophen, 41.7, μmoles/cm. 2 /min.