Radiation and the microenvironment – tumorigenesis and therapy

Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.

[1]  H. Bern,et al.  Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. , 1959, Cancer research.

[2]  A. Upton,et al.  Influence of microbial environment on development of myeloid leukemia in X‐irradiated rfm mice , 1968, International journal of cancer.

[3]  I. M. Neiman,et al.  [Inflammation and cancer]. , 1974, Patologicheskaia fiziologiia i eksperimental'naia terapiia.

[4]  R. Schofield.  The relationship between the spleen colony-forming cell and the haemopoietic stem cell. , 1978, Blood cells.

[5]  D. Penney,et al.  Cell-cell matrix interactions in induced lung injury. I. The effects of X-irradiation on basal laminar proteoglycans. , 1984, Radiation research.

[6]  S. Schnitt,et al.  Radiation-induced changes in the breast. , 1984, Human pathology.

[7]  D. Medina,et al.  Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[8]  D. Lawrence,et al.  Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions , 1985 .

[9]  A. Hercbergs,et al.  Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation. , 1985, International journal of radiation oncology, biology, physics.

[10]  M. Bissell,et al.  Wounding and its role in RSV-mediated tumor formation. , 1985, Science.

[11]  U. Dührsen,et al.  A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient mice. , 1988, Leukemia.

[12]  N. Friedman.  The effects of irradiation on breast cancer and the breast , 1988, CA: a cancer journal for clinicians.

[13]  R. Coffey,et al.  Regulation of intestinal epithelial cell growth by transforming growth factor type beta. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Podolsky,et al.  Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells. , 1989, The Journal of clinical investigation.

[15]  R. Millis,et al.  Radiation and other pathological changes in breast tissue after conservation treatment for carcinoma. , 1990, Journal of clinical pathology.

[16]  U. Dührsen,et al.  Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines. , 1990, Blood.

[17]  M. Anscher,et al.  Transforming growth factor-beta 1 expression in irradiated liver. , 1990, Radiation research.

[18]  J. Leith,et al.  Tumor radiocurability: relationship to intrinsic tumor heterogeneity and to the tumor bed effect. , 1990, Invasion & metastasis.

[19]  M. Sporn,et al.  Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. , 1990, Growth factors.

[20]  M. Martin,et al.  Long-term overproduction of collagen in radiation-induced fibrosis. , 1991, Radiation research.

[21]  D. Rifkin,et al.  The extracellular regulation of growth factor action. , 1992, Molecular biology of the cell.

[22]  I. Kaplan,et al.  Radiation treatment of prostate bone metastases and the biological considerations. , 1992, Advances in experimental medicine and biology.

[23]  D. T. Goodhead,et al.  Transmission of chromosomal instability after plutonium α-particle irradiation , 1992, Nature.

[24]  T. Fitzgerald,et al.  Humoral and cell surface interactions during gamma-irradiation leukemogenesis in vitro. , 1992, Experimental hematology.

[25]  M. Barcellos-Hoff.  Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. , 1993, Cancer research.

[26]  K. Yoshida,et al.  Exacerbating factors of radiation-induced myeloid leukemogenesis. , 1993, Leukemia research.

[27]  W. Thilly,et al.  N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J. Bueren,et al.  Involvement of the bone marrow stroma in the residual hematopoietic damage induced by irradiation of adult and young mice. , 1994, Experimental hematology.

[29]  D. T. Goodhead,et al.  α-particle-induced chromosomal instability in human bone marrow cells , 1994, The Lancet.

[30]  I. Emerit.  Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. , 1994, Free radical biology & medicine.

[31]  R. Derynck,et al.  Transforming growth factor-beta activation in irradiated murine mammary gland. , 1994, The Journal of clinical investigation.

[32]  M. Anscher,et al.  Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ , 1995 .

[33]  M. Bissell,et al.  The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. , 1995, The Journal of clinical investigation.

[34]  Z. Werb,et al.  Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. , 1995, Seminars in cancer biology.

[35]  P. Lohman,et al.  Role of molecular biology in radiation biology. , 1995, International journal of radiation biology.

[36]  T. Dix,et al.  Redox-mediated activation of latent transforming growth factor-beta 1. , 1996, Molecular endocrinology.

[37]  K. Pogue-Geile,et al.  Role of bone marrow stromal cells in irradiation leukemogenesis. , 1996, Acta haematologica.

[38]  E. Cronkite,et al.  Effects of irradiation of CBA/CA mice on hematopoietic stem cells and stromal cells in long-term bone marrow cultures. , 1996, Leukemia.

[39]  E. Wright,et al.  Haemopoietic stem cells: their heterogeneity and regulation , 1997, International journal of experimental pathology.

[40]  C. Potten,et al.  Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo. , 1997, British Journal of Cancer.

[41]  M. Skobe,et al.  Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[42]  D. Goodhead,et al.  Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[43]  V. Fadok,et al.  Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.

[44]  J. Trosko,et al.  Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents. , 1998, Environmental health perspectives.

[45]  M. Barcellos-Hoff,et al.  How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. , 1998, Radiation research.

[46]  M. Hauer-Jensen,et al.  Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. , 1998, The American journal of pathology.

[47]  A. Whetton,et al.  Homing and mobilization in the stem cell niche. , 1999, Trends in cell biology.

[48]  D. Pinkel,et al.  The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis , 1999, Cell.

[49]  M. Barcellos-Hoff,et al.  Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.

[50]  C. Gregory.  CD14-dependent clearance of apoptotic cells: relevance to the immune system. , 2000, Current opinion in immunology.

[51]  Yoshiro Kobayashi,et al.  Transient infiltration of neutrophils into the thymus in association with apoptosis induced by whole‐body X‐irradiation , 2000, Journal of leukocyte biology.

[52]  Simon C Watkins,et al.  Activation of the Nitric Oxide Synthase 2 Pathway in the Response of Bone Marrow Stromal Cells to High Doses of Ionizing Radiation , 2000, Radiation research.

[53]  C. Potten,et al.  Gut instincts: thoughts on intestinal epithelial stem cells. , 2000, The Journal of clinical investigation.

[54]  H. Rodemann,et al.  Spontaneous and radiation-induced differentiationof fibroblasts , 2000, Experimental Gerontology.

[55]  C. Haslett,et al.  AN APPETITE FOR APOPTOTIC CELLS? CONTROVERSIES AND CHALLENGES , 2000, British journal of haematology.

[56]  Kristi Kincaid,et al.  M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.

[57]  E. Wright,et al.  In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations , 2001, International journal of radiation biology.

[58]  M. Barcellos-Hoff,et al.  Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability , 2001, Radiation research.

[59]  E. Nakashima,et al.  Persistent subclinical inflammation among A-bomb survivors , 2001, International journal of radiation biology.

[60]  E. Wright,et al.  Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? , 2001, Oncogene.

[61]  Zvi Fuks,et al.  Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice , 2001, Science.

[62]  F. J. Geske,et al.  The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator , 2002, International journal of hematology.

[63]  John Savill,et al.  A blast from the past: clearance of apoptotic cells regulates immune responses , 2002, Nature Reviews Immunology.

[64]  Mary Helen Barcellos-Hoff,et al.  Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. , 2002, Cancer research.

[65]  A. Fassati,et al.  Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site , 2002, The Journal of cell biology.

[66]  P. Allavena,et al.  Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. , 2002, Trends in immunology.

[67]  Justin P. Annes,et al.  Making sense of latent TGFβ activation , 2003, Journal of Cell Science.

[68]  T. Samulski,et al.  Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. , 2002, International journal of radiation oncology, biology, physics.

[69]  Zvi Fuks,et al.  Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis , 2003, Science.

[70]  P. Bourin,et al.  Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival. , 2003, Blood.

[71]  L. Wakefield,et al.  The two faces of transforming growth factor β in carcinogenesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[72]  James B. Mitchell,et al.  Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. , 2003, The American journal of pathology.

[73]  K. Kodama,et al.  Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors , 2003, International journal of radiation biology.

[74]  S. McCann,et al.  Donor leukaemia: perhaps a more common occurrence than we thought! , 2003, Bone Marrow Transplantation.

[75]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[76]  Paul Dent,et al.  MAPK pathways in radiation responses , 2003, Oncogene.

[77]  James B. Mitchell,et al.  Amelioration of Radiation-induced Fibrosis , 2004, Journal of Biological Chemistry.

[78]  Ana M Soto,et al.  The stroma as a crucial target in rat mammary gland carcinogenesis , 2004, Journal of Cell Science.

[79]  K. Iwamoto,et al.  A Sense of Danger from Radiation1 , 2004, Radiation research.

[80]  M. Barcellos-Hoff,et al.  The Potential Influence of Radiation-Induced Microenvironments in Neoplastic Progression , 1998, Journal of Mammary Gland Biology and Neoplasia.

[81]  E. Wright,et al.  Damaging and protective cell signalling in the untargeted effects of ionizing radiation. , 2004, Mutation research.

[82]  G. Moore,et al.  Radiation-induced Histopathologic Changes of the Breast: The Effects of Time , 2004, The American journal of surgical pathology.

[83]  Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding , 2004, Journal of Cell Science.

[84]  M. Washington,et al.  TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.

[85]  L. Cai,et al.  Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation. , 2004, Experimental hematology.

[86]  Silvano Sozzani,et al.  The chemokine system in diverse forms of macrophage activation and polarization. , 2004, Trends in immunology.

[87]  E. Wright,et al.  Genotype-dependent induction of transmissible chromosomal instability by gamma-radiation and the benzene metabolite hydroquinone. , 2005, Cancer research.

[88]  A. Mantovani,et al.  Smoldering and polarized inflammation in the initiation and promotion of malignant disease. , 2005, Cancer cell.

[89]  J. Little,et al.  Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. , 2005, Cancer research.

[90]  T. Lawrence,et al.  Radiotherapy: what can be achieved by technical improvements in dose delivery? , 2005, The Lancet. Oncology.

[91]  F. Kittrell,et al.  Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia , 2005, Journal of Cell Science.

[92]  W. Anderson,et al.  Soluble factor(s) from bone marrow cells can rescue lethally irradiated mice by protecting endogenous hematopoietic stem cells. , 2005, Experimental hematology.

[93]  E. Wright,et al.  Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to ionizing radiation. , 2005, Journal of proteome research.

[94]  M. Barcellos-Hoff,et al.  A systems biology approach to multicellular and multi-generational radiation responses. , 2006, Mutation research.

[95]  M. Namba,et al.  Effects of feeder layers made of human, mouse, hamster, and rat cells on the cloning efficiency of transformed human cells , 1982, In Vitro.