Translation in Human Eosinophils p 90 S 6 K / RPS 6 Pathway and Increases IL-3 Maintains Activation of the

Mats W. Johansson, James S. Malter and Nizar N. JarjourStephane Esnault, Elizabeth A. B. Kelly, Zhong-Jian Shen,ol.1500871http://www.jimmunol.org/content/early/2015/08/14/jimmunJ Immunol€ published online 14 August 2015MaterialSupplementary1.DCSupplemental.htmlhttp://www.jimmunol.org/content/suppl/2015/08/14/jimmunol.150087Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  I. Pavord,et al.  Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma , 2015, Therapeutic advances in respiratory disease.

[2]  W. Busse,et al.  Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge1 , 2008, The Journal of Immunology.

[3]  O. Meyuhas Physiological roles of ribosomal protein S6: one of its kind. , 2008, International review of cell and molecular biology.

[4]  D. Brenner,et al.  Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. , 2013, The American journal of pathology.

[5]  Johnathan Canton,et al.  Controlling nuclear JAKs and STATs for specific gene activation by IFNγ. , 2011, Biochemical and biophysical research communications.

[6]  S. Orkin,et al.  A Critical Role for Eosinophils in Allergic Airways Remodeling , 2004, Science.

[7]  S. Willsie Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia , 2010 .

[8]  Michael J. Seckl,et al.  Specificity The p 90 RSK Family Members : Common Functions and Isoform , 2013 .

[9]  Brian Raught,et al.  The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity , 2006, The EMBO journal.

[10]  J. Blenis,et al.  RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation* , 2007, Journal of Biological Chemistry.

[11]  S. Phipps,et al.  Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alpha expression. , 2003, Journal of immunology.

[12]  Ana Sousa,et al.  Mepolizumab and exacerbations of refractory eosinophilic asthma. , 2009, The New England journal of medicine.

[13]  N. Jarjour,et al.  Anti‐IL‐5 attenuates activation and surface density of β2‐integrins on circulating eosinophils after segmental antigen challenge , 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[14]  Lin Ying Liu,et al.  Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: I. Loss of Membrane IL-5 Receptor α on Airway Eosinophils and Increased Soluble IL-5 Receptor α in the Airway After Allergen Challenge1 , 2002, The Journal of Immunology.

[15]  M. Takagi,et al.  Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin , 2005, Cell.

[16]  G. Eberl,et al.  Addressing the experimental variability associated with the microbiota , 2015, Mucosal Immunology.

[17]  Lin Ying Liu,et al.  Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. , 2002, Journal of immunology.

[18]  R. Sorkness,et al.  Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. , 2008, The Journal of clinical investigation.

[19]  A. Kay,et al.  Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. , 2003, American journal of respiratory and critical care medicine.

[20]  E. McConkey,et al.  Preferential utilization of phosphorylated 40-S ribosomal subunits during initiation complex formation. , 2005, European journal of biochemistry.

[21]  J. Schroeder,et al.  Human Basophils Secrete IL-3: Evidence of Autocrine Priming for Phenotypic and Functional Responses in Allergic Disease1 , 2009, The Journal of Immunology.

[22]  G. Thomas An encore for ribosome biogenesis in the control of cell proliferation , 2000, Nature Cell Biology.

[23]  N. Jarjour,et al.  Human eosinophils release IL‐1ß and increase expression of IL‐17A in activated CD4+ T lymphocytes , 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[24]  A. Maitra,et al.  Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. , 2013, Cancer research.

[25]  G. Thomas,et al.  Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[26]  N. Surgery Distinctive Blood Eosinophilic Phenotypes and Cytokine Patterns in Eosinophilic Esophagitis, Inflammatory Bowel Disease and Airway Allergy , 2016 .

[27]  S. Gammeltoft,et al.  90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1* , 1999, The Journal of Biological Chemistry.

[28]  Kenneth W Dunn,et al.  A practical guide to evaluating colocalization in biological microscopy. , 2011, American journal of physiology. Cell physiology.

[29]  John A. Hutchinson,et al.  Protein Phosphatase 1 Phosphorylation by Casein Kinase 1 and Regulation of Ribosomal Protein S 6 Signal Transduction : , 2011 .

[30]  C. Dubois,et al.  Differential involvement of NF‐κB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils , 2007, Journal of leukocyte biology.

[31]  J. Blenis,et al.  Nuclear localization and regulation of erk- and rsk-encoded protein kinases , 1992, Molecular and cellular biology.

[32]  I. Bachelet,et al.  The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. , 2006, Blood.

[33]  G. Crabtree,et al.  Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.

[34]  W. Busse,et al.  A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. , 2007, American journal of respiratory and critical care medicine.

[35]  D. Postma,et al.  Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1). , 2010, Respiratory medicine.

[36]  E. Halm,et al.  Detection of immunological biomarkers correlated with asthma control and quality of life measurements in sera from chronic asthmatic patients. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[37]  M. Poo,et al.  Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates , 1999, Cell.

[38]  Lin Ying Liu,et al.  Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils. , 2012, Cytokine.

[39]  Marc E. Rothenberg,et al.  CD48 Is an Allergen and IL-3-Induced Activation Molecule on Eosinophils1 , 2006, The Journal of Immunology.

[40]  E. Lenkiewicz,et al.  Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils , 2004, Science.

[41]  J. Maller,et al.  A protein kinase from Xenopus eggs specific for ribosomal protein S6. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[42]  S. Gammeltoft,et al.  Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction , 1999, Molecular and Cellular Endocrinology.

[43]  D. Jans,et al.  The cytokine interleukin‐5 (IL‐5) effects cotransport of its receptor subunits to the nucleus in vitro , 1997, FEBS letters.

[44]  M. Gaestel,et al.  The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways , 2007, Nature Immunology.

[45]  Steven P. Gygi,et al.  mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.

[46]  R. Homer,et al.  Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis , 2007, The Journal of experimental medicine.

[47]  Lin Ying Liu,et al.  Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: II. IL-5 Down-Modulates Its Receptor Via a Proteinase-Mediated Process1 , 2002, The Journal of Immunology.

[48]  J. Maller,et al.  Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs. , 1988, Second messengers and phosphoproteins.

[49]  O. Nygård,et al.  Identification by RNA‐protein cross‐linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomes. , 1982, The EMBO journal.

[50]  S. Ferrari,et al.  Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. , 1993, The Journal of biological chemistry.

[51]  Yuval Dor,et al.  Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. , 2005, Genes & development.

[52]  W. Farrar,et al.  Interleukin 2 and diacylglycerol stimulate phosphorylation of 40 S ribosomal S6 protein. Correlation with increased protein synthesis and S6 kinase activation. , 1987, Journal of Biological Chemistry.

[53]  S. Shenolikar,et al.  Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. , 2001, Blood.

[54]  S. Phipps,et al.  Differential Regulation of Human Eosinophil IL-3, IL-5, and GM-CSF Receptor α-Chain Expression by Cytokines: IL-3, IL-5, and GM-CSF Down-Regulate IL-5 Receptor α Expression with Loss of IL-5 Responsiveness, but Up-Regulate IL-3 Receptor α Expression 1 , 2003, The Journal of Immunology.

[55]  P. Rosenberger,et al.  Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury , 2013, Mucosal Immunology.

[56]  M. Siegmann,et al.  The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis , 1982, Cell.

[57]  M. Pende,et al.  Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program , 2014, Oncogene.

[58]  Paige Lacy,et al.  Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity , 2014, Front. Immunol..

[59]  W. Busse,et al.  The effect of segmental bronchoprovocation with allergen on airway lymphocyte function. , 1997, American journal of respiratory and critical care medicine.

[60]  Vasudevan Seshadri,et al.  Regulated Release of L13a from the 60S Ribosomal Subunit as A Mechanism of Transcript-Specific Translational Control , 2003, Cell.

[61]  G. Thomas,et al.  Transcriptional and translational control of cytoplasmic proteins after serum stimulation of quiescent Swiss 3T3 cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[62]  H. Rosenberg Eosinophils , 2016, Encyclopedia of Immunobiology.

[63]  S. Durham,et al.  Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. , 1993, The Journal of allergy and clinical immunology.

[64]  I. Weiler,et al.  Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.