Automatic approach bias towards smoking cues is present in smokers but not in ex-smokers

RationaleDrug-addicted individuals show automatic approach tendencies towards drug-related cues, i.e., an approach bias (ApB). Nevertheless, little is known about ApB in tobacco smokers and about the presence of ApB after smoking abstinence.ObjectivesWe investigated ApB to smoking cues in heavy tobacco smokers versus never-smokers and studied its relation to smoking characteristics and craving. Second, we compared ApBs of heavy smokers with biases of abstinent heavy smokers.MethodA group of current heavy smokers (n = 24), ex-smokers who were abstinent for at least 5 years (n = 20), and never-smokers (n = 20) took part in the experiment. An indirect smoking approach avoidance task was performed, in which participants were required to respond to pictures of smoking and neutral cues by pulling (approach) or pushing (avoid) on a joystick, according to the content-irrelevant format of the picture (landscape or portrait). Craving scores were examined using the Questionnaire of Smoking Urges.ResultsHeavy smokers showed an ApB for smoking cues compared to ex-smokers and never-smokers, which correlated positively to craving scores. There were no group differences in ApB scores for ex-smokers and never-smokers.ConclusionThese results suggest that ApBs for smoking cues are present in heavy smokers and decrease after long-term successful smoking cessation.

[1]  G. Badger,et al.  Changes in the relative reinforcing effects of cigarette smoking as a function of initial abstinence , 2009, Psychopharmacology.

[2]  HighWire Press Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[3]  S. Dawe,et al.  Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. , 2004, Addictive behaviors.

[4]  N. Volkow,et al.  Drug addiction: the neurobiology of disrupted self-control. , 2006, Trends in molecular medicine.

[5]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[6]  Sunjeev K Kamboj,et al.  Cue exposure and response prevention with heavy smokers: a laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias , 2011, Psychopharmacology.

[7]  T. Robbins,et al.  Drug addiction: bad habits add up , 1999, Nature.

[8]  Gladys N. Pachas,et al.  Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence , 2010, Biological Psychiatry.

[9]  L. Kozlowski,et al.  The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. , 1991, British journal of addiction.

[10]  J. Patton,et al.  Factor structure of the Barratt impulsiveness scale. , 1995, Journal of clinical psychology.

[11]  J. Hughes,et al.  Relapse to smoking after 1 year of abstinence: a meta-analysis. , 2008, Addictive behaviors.

[12]  O. Aasland,et al.  Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. , 1993, Addiction.

[13]  Reinout W Wiers,et al.  Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use , 2011, Addiction.

[14]  D. Stephens,et al.  AMPA-receptors are involved in the expression of amphetamine-induced behavioural sensitisation, but not in the expression of amphetamine-induced conditioned activity in mice , 1998, Neuropharmacology.

[15]  Jorg Huijding,et al.  Specific predictive power of automatic spider-related affective associations for controllable and uncontrollable fear responses toward spiders. , 2006, Behaviour research and therapy.

[16]  G. Badger,et al.  Influence of the duration of abstinence on the relative reinforcing effects of cigarette smoking , 2005, Psychopharmacology.

[17]  Karin Mogg,et al.  Selective Processing of Smoking-Related Cues in Current Smokers, Ex-Smokers and Never-Smokers on the Modified Stroop Task , 2003, Journal of psychopharmacology.

[18]  I. Franken,et al.  Intentional Modulation of the Late Positive Potential in Response to Smoking Cues by Cognitive Strategies in Smokers , 2011, PloS one.

[19]  Remco C. Havermans,et al.  Pavlovian conditioning of an approach bias in low-dependent smokers , 2007, Psychopharmacology.

[20]  Reinout W. Wiers,et al.  Approach bias modification in alcohol dependence: Do clinical effects replicate and for whom does it work best? , 2013, Developmental Cognitive Neuroscience.

[21]  S. Shiffman,et al.  Attentional bias predicts outcome in smoking cessation. , 2003, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[22]  D. Drobes,et al.  Attentional bias for smoking and affective stimuli: a Stroop task study. , 2006, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[23]  A. Bechara Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective , 2005, Nature Neuroscience.

[24]  R. C. Oldfield The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[25]  Reinout W Wiers,et al.  Implicit cognition and addiction: a tool for explaining paradoxical behavior. , 2010, Annual review of clinical psychology.

[26]  Meng Zhang,et al.  Behavioural approach tendencies to heroin-related stimuli in abstinent heroin abusers , 2011, Psychopharmacology.

[27]  B. Pitt Psychopharmacology , 1968, Mental Health.

[28]  K. C. Klauer,et al.  The Psychology of Evaluation : Affective Processes in Cognition and Emotion , 2003 .

[29]  Jan De Houwer,et al.  What Are Implicit Measures and Why Are We Using Them , 2006 .

[30]  D H Brainard,et al.  The Psychophysics Toolbox. , 1997, Spatial vision.

[31]  M. Munafo,et al.  GENETIC STUDY: Smoking status moderates the association of the dopamine D4 receptor (DRD4) gene VNTR polymorphism with selective processing of smoking‐related cues , 2008, Addiction biology.

[32]  T. Hergueta,et al.  The mini international neuropsychiatric interview , 1998, European Psychiatry.

[33]  K. Mogg,et al.  Attentional and approach biases for smoking cues in smokers: an investigation of competing theoretical views of addiction , 2005, Psychopharmacology.

[34]  T. Heatherton,et al.  Spontaneous Action Representation in Smokers when Watching Movie Characters Smoke , 2011, The Journal of Neuroscience.

[35]  A. Beck,et al.  Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. , 1996, Journal of personality assessment.

[36]  Liam Nestor,et al.  Differences in “bottom-up” and “top-down” neural activity in current and former cigarette smokers: Evidence for neural substrates which may promote nicotine abstinence through increased cognitive control , 2011, NeuroImage.

[37]  S. Tiffany,et al.  A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. , 1990, Psychological review.

[38]  R. Wiers,et al.  Retraining Automatic Action Tendencies Changes Alcoholic Patients’ Approach Bias for Alcohol and Improves Treatment Outcome , 2011, Psychological science.

[39]  K. Mogg,et al.  Attentional and evaluative biases for smoking cues in nicotine dependence: component processes of biases in visual orienting , 2004, Behavioural pharmacology.

[40]  R. Wiers,et al.  Handbook of implicit cognition and addiction , 2006 .

[41]  B. Hommel,et al.  Motivational Mechanisms and Outcome Expectancies Underlying the Approach Bias toward Addictive Substances , 2012, Front. Psychology.

[42]  Ute Leonards,et al.  Attentional bias training and cue reactivity in cigarette smokers. , 2008, Addiction.

[43]  Jerry L. Grenard,et al.  Automatic and controlled processes and the development of addictive behaviors in adolescents: A review and a model , 2007, Pharmacology Biochemistry and Behavior.

[44]  W F Velicer,et al.  Decisional balance measure for assessing and predicting smoking status. , 1985, Journal of personality and social psychology.

[45]  K. Mogg,et al.  Do the affective properties of smoking-related cues influence attentional and approach biases in cigarette smokers? , 2008, Journal of psychopharmacology.

[46]  M. Munafo,et al.  Association of serotonin transporter genotype with selective processing of smoking-related stimuli in current smokers and ex-smokers. , 2005, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[47]  L. Cox,et al.  Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. , 2001, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[48]  Jan De Houwer,et al.  A structural analysis of indirect measures of attitudes , 2003 .

[49]  Greg O. Horne,et al.  Controlling low-level image properties: The SHINE toolbox , 2010, Behavior research methods.

[50]  S. Shiffman,et al.  The relevance and treatment of cue-induced cravings in tobacco dependence. , 2009, Journal of substance abuse treatment.

[51]  R. Wiers,et al.  Relatively strong automatic appetitive action‐tendencies in male carriers of the OPRM1 G‐allele , 2009, Genes, brain, and behavior.

[52]  Ann-Christine Ehlis,et al.  Prefrontal correlates of approach preferences for alcohol stimuli in alcohol dependence , 2014, Addiction biology.

[53]  T. Robbins,et al.  Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[54]  Reinout W. Wiers,et al.  Cognitive Bias Modification and Cognitive Control Training in Addiction and Related Psychopathology , 2013 .

[55]  R. Wiers,et al.  Retraining automatic action-tendencies to approach alcohol in hazardous drinkers. , 2010, Addiction.

[56]  M. Pérez-García,et al.  Ecological assessment of executive functions in substance dependent individuals. , 2007, Drug and alcohol dependence.

[57]  K. Berridge,et al.  The neural basis of drug craving: An incentive-sensitization theory of addiction , 1993, Brain Research Reviews.

[58]  K. Berridge Faculty Opinions recommendation of Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. , 2008 .

[59]  B. Hommel,et al.  Motivational Mechanisms Underlying the Approach Bias to Cigarettes , 2013 .

[60]  Matt Field,et al.  Eye movements to smoking-related pictures in smokers: relationship between attentional biases and implicit and explicit measures of stimulus valence. , 2003, Addiction.

[61]  Roland Deutsch,et al.  Comparing measures of approach–avoidance behaviour: The manikin task vs. two versions of the joystick task , 2010 .

[62]  Andrew J Waters,et al.  Attentional shifts to smoking cues in smokers. , 2003, Addiction.

[63]  C. Feyerabend,et al.  Determinants and effects of attentional bias in smokers. , 2000, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[64]  Lee Hogarth,et al.  Attentional orienting towards smoking-related stimuli , 2003, Behavioural pharmacology.

[65]  P. Pini Addiction , 1996, The Lancet.

[66]  M. Rinck,et al.  Approach and avoidance in fear of spiders. , 2007, Journal of behavior therapy and experimental psychiatry.

[67]  Vicki W. Chanon,et al.  Attentional bias toward cigarette cues in active smokers , 2010, Psychopharmacology.