Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A

[1]  K. Clarke,et al.  Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species , 2017, The international journal of biochemistry & cell biology.

[2]  A. Luttun,et al.  The role of fatty acid β-oxidation in lymphangiogenesis , 2016, Nature.

[3]  P. Carmeliet,et al.  Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective? , 2016, Pharmacological Reviews.

[4]  K. Wagner,et al.  Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy , 2016, PPAR research.

[5]  P. Carmeliet,et al.  FOXO1 couples metabolic activity and growth state in the vascular endothelium , 2015, Nature.

[6]  F. Perez-Vizcaino,et al.  Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction. , 2015, Clinical science.

[7]  P. Carmeliet,et al.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.

[8]  A. Luttun,et al.  Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake , 2015, Circulation.

[9]  Eytan Ruppin,et al.  Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability* , 2015, Molecular & Cellular Proteomics.

[10]  B. Desvergne,et al.  Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function , 2015, Nuclear receptor signaling.

[11]  H. Kozakewich,et al.  Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses , 2015, Angiogenesis.

[12]  W. Hall,et al.  A thin layer angiogenesis assay: a modified basement matrix assay for assessment of endothelial cell differentiation , 2014, BMC Cell Biology.

[13]  D. Bishop-Bailey,et al.  A thin layer angiogenesis assay: a modified basement matrix assay for assessment of endothelial cell differentiation , 2014, BMC Cell Biology.

[14]  Z. Fei,et al.  Activation of peroxisome proliferator-activated receptor β/δ attenuates acute ischemic stroke on middle cerebral ischemia occlusion in rats. , 2014, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[15]  P. Carmeliet,et al.  Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. , 2014, Cell metabolism.

[16]  A. Zeiher,et al.  Laminar Shear Stress Inhibits Endothelial Cell Metabolism via Krüppel-Like Factor 2 – Mediated Repression of 6-Phosphofructo-2-Kinase / Fructose-2 , 6-Biphosphatase-3 , 2014 .

[17]  D. Alvarez,et al.  Lactate Dehydrogenase A Expression Is Necessary to Sustain Rapid Angiogenesis of Pulmonary Microvascular Endothelium , 2013, PloS one.

[18]  P. Carmeliet,et al.  Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.

[19]  Sara R. Savage,et al.  Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy. , 2013, Investigative ophthalmology & visual science.

[20]  Min Young Kim,et al.  The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent. , 2012, Biochemical pharmacology.

[21]  P. Ward,et al.  Signaling in control of cell growth and metabolism. , 2012, Cold Spring Harbor perspectives in biology.

[22]  Hyun-Joung Lim,et al.  The PPARδ ligand L‐165041 inhibits vegf‐induced angiogenesis, but the antiangiogenic effect is not related to PPARδ , 2012, Journal of cellular biochemistry.

[23]  Shaghayegh Haghjooy Javanmard,et al.  Role of peroxisome proliferator-activated receptor β agonist on angiogenesis in hindlimb ischemic diabetic rats. , 2012, Journal of diabetes and its complications.

[24]  Didier Y. R. Stainier,et al.  Molecular control of endothelial cell behaviour during blood vessel morphogenesis , 2011, Nature Reviews Molecular Cell Biology.

[25]  F. Dequiedt,et al.  Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase , 2011, Nature.

[26]  Christian M. Metallo,et al.  Metabolic pathway alterations that support cell proliferation. , 2011, Cold Spring Harbor symposia on quantitative biology.

[27]  W. Dunn,et al.  Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[28]  C. Thiemermann,et al.  ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-&bgr;/&dgr; ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT , 2010, Shock.

[29]  A. Al-Mehdi,et al.  Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[30]  V. Darley-Usmar,et al.  Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. , 2010, Free radical biology & medicine.

[31]  Huan Yang,et al.  Peroxisome Proliferator-Activated Receptor &dgr; Is an Essential Transcriptional Regulator for Mitochondrial Protection and Biogenesis in Adult Heart , 2010, Circulation research.

[32]  J. Mitchell,et al.  The PPARβ/δAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension , 2010, PloS one.

[33]  J. Boyle,et al.  PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. , 2010, Cardiovascular research.

[34]  K. Wagner,et al.  Peroxisome proliferator-activated receptor beta stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin. , 2009, Cardiovascular research.

[35]  J. Mitchell,et al.  Activation of PPARβ/δ inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release , 2009, Journal of leukocyte biology.

[36]  Marta Cascante,et al.  Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets. , 2009, Carcinogenesis.

[37]  Xianzhong Xiao,et al.  Enhancement of PPAR-beta activity by repetitive low-grade H(2)O(2) stress protects human umbilical vein endothelial cells from subsequent oxidative stress-induced apoptosis. , 2009, Free radical biology & medicine.

[38]  V. Sridharan,et al.  VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  XianWang,et al.  Suppression of Pro-inflammatory Adhesion Molecules by PPAR-δ in Human Vascular Endothelial Cells , 2008 .

[40]  S. Chien,et al.  Suppression of Pro-inflammatory Adhesion Molecules by PPAR-&dgr; in Human Vascular Endothelial Cells , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[41]  F. Alt,et al.  SIRT1 controls endothelial angiogenic functions during vascular growth. , 2007, Genes & development.

[42]  Cuk-Seong Kim,et al.  SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase , 2007, Proceedings of the National Academy of Sciences.

[43]  O. Dormond,et al.  The Effects of mTOR-Akt Interactions on Anti-apoptotic Signaling in Vascular Endothelial Cells* , 2007, Journal of Biological Chemistry.

[44]  T. K. Hunt,et al.  Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. , 2007, Antioxidants & redox signaling.

[45]  P. Puigserver,et al.  Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α , 2007, The EMBO journal.

[46]  J. Redondo,et al.  Activation of PPAR&bgr;/&dgr; Induces Endothelial Cell Proliferation and Angiogenesis , 2007 .

[47]  J. Redondo,et al.  Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[48]  Jaetaek Kim,et al.  The Peroxisome Proliferator-Activated Receptor δ Agonist, GW501516, Inhibits Angiogenesis through Dephosphorylation of Endothelial Nitric Oxide Synthase , 2006 .

[49]  R. DePinho,et al.  Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. , 2005, The Journal of clinical investigation.

[50]  W. Wahli,et al.  Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure. , 2005, Journal of the American Society of Nephrology : JASN.

[51]  Bart Landuyt,et al.  Vascular Endothelial Growth Factor and Angiogenesis , 2004, Pharmacological Reviews.

[52]  Michael D. Schneider,et al.  Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy , 2004, Nature Medicine.

[53]  R. Evans,et al.  Regulation of Muscle Fiber Type and Running Endurance by PPARδ , 2004, PLoS biology.

[54]  A. Harris,et al.  Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. , 2004, Cancer research.

[55]  G. Lopaschuk,et al.  Measurements of fatty acid and carbohydrate metabolism in te isolated working rat heart , 1997, Molecular and Cellular Biochemistry.

[56]  A. Harris,et al.  Activation of Peroxisome Proliferator-Activated Receptor Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines , 2004 .

[57]  Johan Auwerx,et al.  Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[58]  T. Willson,et al.  Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity , 2003 .

[59]  M. Muraguchi,et al.  Up‐regulation of vascular endothelial growth factor in response to glucose deprivation , 1998, Biology of the cell.

[60]  E. Sage,et al.  PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors , 1994, The Journal of cell biology.

[61]  R. Spahr,et al.  Metabolism of exogenous substrates by coronary endothelial cells in culture. , 1990, Journal of molecular and cellular cardiology.

[62]  F. Rossi,et al.  Metabolic properties of freshly isolated bovine endothelial cells. , 1983, Biochimica et biophysica acta.

[63]  R. Hammerstedt.  The use of Dowex-1-borate to separate 3HOH from 2-3H-glucose. , 1973, Analytical biochemistry.