Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells
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[1] P. Ji,et al. Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain. , 2011, Bioorganic & medicinal chemistry letters.
[2] P. R. Deepa,et al. Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study. , 2011, Experimental and molecular pathology.
[3] Suranjana Das,et al. Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing , 2010, PloS one.
[4] P. R. Deepa,et al. Evaluation of suitable solvents for testing the anti-proliferative activity of triclosan - a hydrophobic drug in cell culture. , 2010, Indian journal of biochemistry & biophysics.
[5] Armin Ruf,et al. Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design. , 2010, Journal of molecular biology.
[6] Pascal Benkert,et al. QMEAN server for protein model quality estimation , 2009, Nucleic Acids Res..
[7] Site Li,et al. Novel fatty acid synthase (FAS) inhibitors: design, synthesis, biological evaluation, and molecular docking studies. , 2009, Bioorganic & medicinal chemistry.
[8] Timm Maier,et al. The Crystal Structure of a Mammalian Fatty Acid Synthase , 2008, Science.
[9] E. Gabrielson,et al. Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment , 2007, Clinical Cancer Research.
[10] J. Menéndez,et al. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.
[11] Y. Wong,et al. Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. , 2007, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[12] H. Kubinyi. Hydrogen Bonding: The Last Mystery in Drug Design? , 2007 .
[13] Michael Levitt,et al. Near-native structure refinement using in vacuo energy minimization , 2007, Proceedings of the National Academy of Sciences.
[14] Gerd Folkers,et al. Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies , 2006 .
[15] J. Menéndez,et al. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.
[16] Ram Samudrala,et al. Prediction of HIV-1 Protease Inhibitor Resistance using a Protein–Inhibitor Flexible Docking Approach , 2005, Antiviral therapy.
[17] J. Menéndez,et al. Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells. , 2004, Archivum immunologiae et therapiae experimentalis.
[18] M. C. Archer,et al. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. , 2004, Carcinogenesis.
[19] Jeffrey W. Smith,et al. Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity , 2004, Cancer Research.
[20] F. Camassei,et al. Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness. , 2003, Investigative ophthalmology & visual science.
[21] S. Peikin,et al. Orlistat: its current status as an anti-obesity drug. , 2002, European journal of pharmacology.
[22] V. Anderson,et al. Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells , 2002, Cancer Chemotherapy and Pharmacology.
[23] F. Kuhajda,et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. , 2001, Biochemical and biophysical research communications.
[24] F. Kuhajda. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. , 2000, Nutrition.
[25] David S. Goodsell,et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function , 1998, J. Comput. Chem..
[26] H. Kubinyi. Structure-based design of enzyme inhibitors and receptor ligands. , 1998, Current opinion in drug discovery & development.
[27] J. Thornton,et al. AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR , 1996, Journal of biomolecular NMR.
[28] L. Jacobs,et al. Fatty acid synthesis: a potential selective target for antineoplastic therapy. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[29] S. Kridel,et al. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat , 2007, Nature Structural &Molecular Biology.
[30] Robert K. Murray,et al. Harper's Illustrated Biochemistry , 2003 .
[31] A. Sali,et al. Modeller: generation and refinement of homology-based protein structure models. , 2003, Methods in enzymology.
[32] C. Townsend,et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[33] E. M. Carey,et al. Fatty acid synthase from rabbit mammary gland. , 1975, Methods in enzymology.