Microalgae biorefinery: High value products perspectives.

Microalgae have received much interest as a biofuel feedstock in response to the uprising energy crisis, climate change and depletion of natural sources. Development of microalgal biofuels from microalgae does not satisfy the economic feasibility of overwhelming capital investments and operations. Hence, high-value co-products have been produced through the extraction of a fraction of algae to improve the economics of a microalgae biorefinery. Examples of these high-value products are pigments, proteins, lipids, carbohydrates, vitamins and anti-oxidants, with applications in cosmetics, nutritional and pharmaceuticals industries. To promote the sustainability of this process, an innovative microalgae biorefinery structure is implemented through the production of multiple products in the form of high value products and biofuel. This review presents the current challenges in the extraction of high value products from microalgae and its integration in the biorefinery. The economic potential assessment of microalgae biorefinery was evaluated to highlight the feasibility of the process.

[1]  Jo-Shu Chang,et al.  Supercritical fluid extraction of valuable compounds from microalgal biomass. , 2015, Bioresource technology.

[2]  Jo‐Shu Chang,et al.  Engineering strategies for simultaneous enhancement of C-phycocyanin production and CO2 fixation with Spirulina platensis. , 2013, Bioresource technology.

[3]  Malcolm R. Brown,et al.  Riboflavin content of six species of microalgae used in mariculture , 1994, Journal of Applied Phycology.

[4]  Steven Van Passel,et al.  A techno-economic assessment of an algal-based biorefinery , 2016, Clean Technologies and Environmental Policy.

[5]  P. Biller,et al.  Hydrothermal microwave processing of microalgae as a pre-treatment and extraction technique for bio-fuels and bio-products. , 2013, Bioresource technology.

[6]  Tong Wang,et al.  Evaluation of microalgae cell disruption by ultrasonic treatment. , 2012, Bioresource technology.

[7]  Ioannis D. Manariotis,et al.  Effect of operating conditions on Chlorococcum sp. growth and lipid production , 2016 .

[8]  P. McGinn,et al.  Pilot-scale supercritical carbon dioxide extractions for the recovery of triacylglycerols from microalgae: a practical tool for algal biofuels research , 2011, Journal of Applied Phycology.

[9]  David M. Karl,et al.  Vitamin B12 excretion by cultures of the marine cyanobacteria Crocosphaera and Synechococcus , 2010 .

[10]  T. Wu,et al.  Biodiesel production from Jatropha oil by catalytic and non-catalytic approaches: an overview. , 2011, Bioresource technology.

[11]  Colin J Barrow,et al.  Characterization of a new zeaxanthin producing strain of Chlorella saccharophila isolated from New Zealand marine waters. , 2013, Bioresource Technology.

[12]  Roberto Parra-Saldivar,et al.  Algae Biofuels Production Processes, Carbon Dioxide Fixation and Biorefinery Concept , 2014 .

[13]  Viatcheslav Kafarov,et al.  MICROALGAE BASED BIOREFINERY: ISSUES TO CONSIDER , 2011 .

[14]  Jonathan Moncada,et al.  Design and analysis of a second and third generation biorefinery: The case of castorbean and microalgae. , 2015, Bioresource technology.

[15]  Jo-Shu Chang,et al.  Engineering strategies for enhancing the production of eicosapentaenoic acid (EPA) from an isolated microalga Nannochloropsis oceanica CY2. , 2013, Bioresource technology.

[16]  M. Camargo,et al.  Key challenges and requirements for sustainable and industrialized biorefinery supply chain design and management: A bibliographic analysis , 2017 .

[17]  Y. Chisti Biodiesel from microalgae. , 2007, Biotechnology advances.

[18]  R. P. John,et al.  Micro and macroalgal biomass: a renewable source for bioethanol. , 2011, Bioresource technology.

[19]  Jason C. Quinn,et al.  The potentials and challenges of algae based biofuels: a review of the techno-economic, life cycle, and resource assessment modeling. , 2015, Bioresource technology.

[20]  Wen Tong Chong,et al.  Microalgae biofuels as an alternative to fossil fuel for power generation , 2016 .

[21]  Duu-Jong Lee,et al.  Production, extraction and stabilization of lutein from microalga Chlorella sorokiniana MB-1. , 2016, Bioresource technology.

[22]  Artiwan Shotipruk,et al.  Response surface methodology to supercritical carbon dioxide extraction of astaxanthin from Haematococcus pluvialis. , 2008, Bioresource technology.

[23]  Ryan Davis,et al.  Techno-economic analysis of autotrophic microalgae for fuel production , 2011 .

[24]  Seraphim Papanikolaou,et al.  Evaluating renewable carbon sources as substrates for single cell oil production by Cunninghamella echinulata and Mortierella isabellina. , 2009 .

[25]  Y. Oh,et al.  Cell-wall disruption and lipid/astaxanthin extraction from microalgae: Chlorella and Haematococcus. , 2016, Bioresource technology.

[26]  Gisel Chenard Díaz,et al.  Biodiesel Production Based in Microalgae: A Biorefinery Approach , 2015 .

[27]  Chen-Hsi Cheng,et al.  Microalgal pigments potential as byproducts in lipid production , 2011 .

[28]  T. Fatma,et al.  Studies on Anabaena sp. NCCU-9 with special reference to phycocyanin , 2011 .

[29]  Jason C. Quinn,et al.  Microalgae to biofuels lifecycle assessment — Multiple pathway evaluation , 2014 .

[30]  S. Scott,et al.  Life cycle assessment on microalgal biodiesel production using a hybrid cultivation system. , 2014, Bioresource technology.

[31]  Qingshi Tu Life Cycle Assessment of Biodiesel , 2019, World Biodiesel Policies and Production.

[32]  N Kumaresan,et al.  Extraction, purification and concentration of partially saturated canthaxanthin from Aspergillus carbonarius. , 2010, Bioresource technology.

[33]  V. M. Ortiz-Martínez,et al.  A critical review on microalgae as an alternative source for bioenergy production: A promising low cost substrate for microbial fuel cells , 2016 .

[34]  Han Min Woo,et al.  Synergistic effect of multiple stress conditions for improving microalgal lipid production , 2016 .

[35]  K. Raghavarao,et al.  Fractionation and purification of the phycobiliproteins from Spirulina platensis. , 2008, Bioresource technology.

[36]  Enrica Uggetti,et al.  Photosynthetic membrane-less microbial fuel cells to enhance microalgal biomass concentration. , 2016, Bioresource technology.

[37]  Jorge Alberto Vieira Costa,et al.  The role of biochemical engineering in the production of biofuels from microalgae. , 2011, Bioresource technology.

[38]  H. Masjuki,et al.  Macroalgae and microalgae as a potential source for commercial applications along with biofuels production: A biorefinery approach , 2016 .

[39]  Ke Li,et al.  Enhancing the growth rate and astaxanthin yield of Haematococcus pluvialis by nuclear irradiation and high concentration of carbon dioxide stress. , 2016, Bioresource technology.

[40]  H. Sovová,et al.  A biorefinery from Nannochloropsis sp. microalga--extraction of oils and pigments. Production of biohydrogen from the leftover biomass. , 2013, Bioresource technology.

[41]  Jo-Shu Chang,et al.  Synergistic enhancement of glycogen production in Arthrospira platensis by optimization of light intensity and nitrate supply. , 2012, Bioresource technology.

[42]  R. Sims,et al.  Production and harvesting of microalgae for wastewater treatment, biofuels, and bioproducts. , 2011, Biotechnology advances.

[43]  Jo-Shu Chang,et al.  Achieving high lipid productivity of a thermotolerant microalga Desmodesmus sp. F2 by optimizing environmental factors and nutrient conditions. , 2014, Bioresource technology.

[44]  F. Chemat,et al.  "Solvent-free" ultrasound-assisted extraction of lipids from fresh microalgae cells: a green, clean and scalable process. , 2012, Bioresource technology.

[45]  P. Schenk,et al.  A comparative study: the impact of different lipid extraction methods on current microalgal lipid research , 2014, Microbial Cell Factories.

[46]  Duu-Jong Lee,et al.  Lutein recovery from Chlorella sp. ESP-6 with coagulants. , 2013, Bioresource technology.

[47]  C. Posten,et al.  Microalgae and terrestrial biomass as source for fuels--a process view. , 2009, Journal of biotechnology.

[48]  Duu-Jong Lee,et al.  Microalgae-based biorefinery--from biofuels to natural products. , 2013, Bioresource technology.

[49]  P. Spolaore,et al.  Commercial applications of microalgae. , 2006, Journal of bioscience and bioengineering.

[50]  Wai Yan Cheah,et al.  Biosequestration of atmospheric CO2 and flue gas-containing CO2 by microalgae. , 2015, Bioresource technology.

[51]  M. Ferruzzi,et al.  Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives , 2007 .

[52]  Hsien Hui Khoo,et al.  Life cycle energy and CO2 analysis of microalgae-to-biodiesel: preliminary results and comparisons. , 2011, Bioresource technology.

[53]  Prasant Kumar Rout,et al.  Production of first and second generation biofuels: A comprehensive review , 2010 .

[54]  Guangming Zhang,et al.  Biomass and pigments production in photosynthetic bacteria wastewater treatment: Effects of photoperiod. , 2015, Bioresource technology.

[55]  A. Bertucco,et al.  Biofuels from microalgae: lipid extraction and methane production from the residual biomass in a biorefinery approach. , 2014, Bioresource technology.

[56]  Jo-Shu Chang,et al.  Effects of cultivation conditions and media composition on cell growth and lipid productivity of indigenous microalga Chlorella vulgaris ESP-31. , 2012, Bioresource technology.

[57]  Ramkrishna Sen,et al.  Downstream processing of microalgal feedstock for lipid and carbohydrate in a biorefinery concept: a holistic approach for biofuel applications , 2016 .

[58]  Ruitang Deng,et al.  Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina. , 2010, Cardiovascular therapeutics.

[59]  Walter Klöpffer,et al.  Life cycle assessment , 1997, Environmental science and pollution research international.

[60]  Artur M. S. Silva,et al.  Extraction and quantification of pigments from a marine microalga: a simple and reproducible method , 2007 .

[61]  Julie B Zimmerman,et al.  Evaluating microalgal integrated biorefinery schemes: empirical controlled growth studies and life cycle assessment. , 2014, Bioresource technology.

[62]  Duu-Jong Lee,et al.  Enhancing lutein productivity of an indigenous microalga Scenedesmus obliquus FSP-3 using light-related strategies. , 2014, Bioresource technology.

[63]  Jun Wang,et al.  From microalgae oil to produce novel structured triacylglycerols enriched with unsaturated fatty acids. , 2015, Bioresource technology.

[64]  Luísa Gouveia,et al.  Effect of light on the production of bioelectricity and added-value microalgae biomass in a Photosynthetic Alga Microbial Fuel Cell. , 2014, Bioresource technology.

[65]  Martin K. Patel,et al.  Conceptual design of sustainable integrated microalgae biorefineries : Parametric analysis of energy use, greenhouse gas emissions and techno-economics , 2016 .

[66]  C. Thurston,et al.  Microbial fuel-cells , 1993 .

[67]  W. Cong,et al.  Enzyme-assisted aqueous extraction of lipid from microalgae. , 2012, Journal of agricultural and food chemistry.

[68]  Jo-Shu Chang,et al.  Enhancing the production of eicosapentaenoic acid (EPA) from Nannochloropsis oceanica CY2 using innovative photobioreactors with optimal light source arrangements. , 2015, Bioresource technology.

[69]  Philip Owende,et al.  Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products , 2010 .

[70]  Alejandro Cifuentes,et al.  Pressurized liquids as an alternative process to antioxidant carotenoids' extraction from Haematococcus pluvialis microalgae , 2010 .

[71]  Hsien Hui Khoo,et al.  Bioenergy co-products derived from microalgae biomass via thermochemical conversion--life cycle energy balances and CO2 emissions. , 2013, Bioresource technology.

[72]  Wolter Prins,et al.  Assessing microalgae biorefinery routes for the production of biofuels via hydrothermal liquefaction. , 2014, Bioresource technology.

[73]  Freddy Guihéneuf,et al.  The Anti-Inflammatory Effect of Algae-Derived Lipid Extracts on Lipopolysaccharide (LPS)-Stimulated Human THP-1 Macrophages , 2015, Marine drugs.

[74]  Jo‐Shu Chang,et al.  Exploring the potential of using algae in cosmetics. , 2015, Bioresource technology.

[75]  Hitoshi Tamiaki,et al.  Synthesis of zinc 20-substituted bacteriochlorophyll-d analogs and their self-aggregation , 2014 .

[76]  Jo-Shu Chang,et al.  Biosequestration of atmospheric CO 2 and flue gas-containing CO 2 by microalgae , 2017 .

[77]  Rene H Wijffels,et al.  Biorefinery of microalgae for food and fuel. , 2013, Bioresource technology.

[78]  A. Lawal,et al.  Techno‐economics of microalgae production and conversion to refinery‐ready oil with co‐product credits , 2015 .

[79]  E. Shalaby,et al.  Aqueous extracts of microalgae exhibit antioxidant and anticancer activities. , 2012, Asian Pacific journal of tropical biomedicine.

[80]  R. Saxena,et al.  Bio-fuels from thermochemical conversion of renewable resources: A review , 2008 .

[81]  Xu Fang,et al.  Microbial lipid production by the oleaginous yeast Cryptococcus curvatus O3 grown in fed-batch culture , 2011 .

[82]  S. Hsu,et al.  Supercritical fluids extraction and anti-solvent purification of carotenoids from microalgae and associated bioactivity , 2010 .

[83]  Ying Li,et al.  Isolation of a novel alkaline-stable lipase from a metagenomic library and its specific application for milkfat flavor production , 2014, Microbial Cell Factories.

[84]  Thirumurthy Velpandian,et al.  Evaluation of antiangiogenic and antiproliferative potential of the organic extract of green algae chlorella pyrenoidosa , 2013, Indian journal of pharmacology.

[85]  D. Batten,et al.  Life cycle assessment of biodiesel production from microalgae in ponds. , 2011, Bioresource technology.