Genetic polymorphisms and drug interactions modulating CYP 2 D 6 and CYP 3 A activities have a major effect on oxycodone analgesic efficacy and safetybph

1Clinical Pharmacology and Toxicology and Multidisciplinary Pain Centre, Department of Anaesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, Geneva, Switzerland, 2Swiss Centre for Applied Human Toxicology (SCAHT), Geneva University, Geneva, Switzerland, 3Life Science Mass Spectrometry, School of Pharmaceutical Sciences, University of Lausanne, University of Geneva, Geneva, Switzerland, 4Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, Prilly Lausanne, Switzerland, 5School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland, and 6Service of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland