The scientific effort to control the interaction between light and matter has grown exponentially in the last two decades. This growth has been aided by the development of scientific and technological tools enabling the manipulation of light at deeply sub-wavelength scales, unlocking a large variety of novel phenomena spanning traditionally distant research areas. In this paper, we review the role of chirality in light-matter interactions by providing a broad overview of its properties, materials and applications. A perspective on future developments is highlighted, including the growing role of machine learning in designing advanced chiroptical materials to enhance and control light-matter interactions across several scales. This article is protected by copyright. All rights reserved.