Down regulation of pRb in cultures of avian neuroretina cells promotes proliferation of reactive Müller-like cells and emergence of retinal stem/progenitors.

[1]  S. Jhanwar,et al.  Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling , 2009, Cell.

[2]  T. Corson,et al.  Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma. , 2008, Human molecular genetics.

[3]  A. Garelli,et al.  Trophic factors and neuronal interactions regulate the cell cycle and Pax6 expression in Müller stem cells , 2008, Journal of neuroscience research.

[4]  J. Wan,et al.  Preferential regeneration of photoreceptor from Müller glia after retinal degeneration in adult rat , 2008, Vision Research.

[5]  J. Ge,et al.  Identification of tumorigenic retinal stem‐like cells in human solid retinoblastomas , 2007 .

[6]  I. Bayazitov,et al.  Differentiated Horizontal Interneurons Clonally Expand to Form Metastatic Retinoblastoma in Mice , 2007, Cell.

[7]  M. Dyer,et al.  Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy. , 2007, Cancer research.

[8]  N. Tanimoto,et al.  Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a , 2007, PLoS biology.

[9]  Laura Harwood,et al.  Isolation of retinal progenitor and stem cells from the porcine eye , 2007, Molecular vision.

[10]  Linda K. Barthel,et al.  Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells , 2007, The Journal of Neuroscience.

[11]  Maria Marx,et al.  Stable expression of intracellular Notch suppresses v-Src-induced transformation in avian neural cells , 2007, Oncogene.

[12]  David S. Park,et al.  Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions , 2007, Molecular and Cellular Biology.

[13]  T. Jacks,et al.  Murine bilateral retinoblastoma exhibiting rapid‐onset, metastatic progression and N‐myc gene amplification , 2007, The EMBO journal.

[14]  N. Tétreault,et al.  Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle. , 2007, Developmental biology.

[15]  S. Donovan,et al.  Compensation by tumor suppressor genes during retinal development in mice and humans , 2006, BMC Biology.

[16]  S. Bilodeau,et al.  Retinoblastoma and the Related Pocket Protein p107 Act as Coactivators of NeuroD1 to Enhance Gene Transcription* , 2005, Journal of Biological Chemistry.

[17]  D. Cobrinik Pocket proteins and cell cycle control , 2005, Oncogene.

[18]  D. A. Cameron,et al.  Responses of Müller glia to retinal injury in adult zebrafish , 2005, Vision Research.

[19]  A. Fischer,et al.  Transitin, a nestin‐related intermediate filament, is expressed by neural progenitors and can be induced in Müller glia in the chicken retina , 2005, The Journal of comparative neurology.

[20]  T. Reh,et al.  Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. , 2004, Molecular vision.

[21]  T. Jacks,et al.  Cell type-specific effects of Rb deletion in the murine retina. , 2004, Genes & development.

[22]  R. Slack,et al.  Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. , 2004, Cancer cell.

[23]  E. Huillard,et al.  Localized expression of drm/gremlin in the central nervous system of the chicken embryo , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[24]  Ani V Das,et al.  Neural stem cells in the mammalian eye: types and regulation. , 2004, Seminars in cell & developmental biology.

[25]  P. Layer,et al.  Embryonic chicken retinal cells can regenerate all cell layers in vitro, but ciliary pigmented cells induce their correct polarity , 1989, Cell and Tissue Research.

[26]  A. Privat,et al.  Differentiation of chick embryo neuroretina cells in monolayer cultures. An ultrastructural study , 1977, Cell and Tissue Research.

[27]  T. Reh,et al.  Potential of Müller glia to become neurogenic retinal progenitor cells , 2003, Glia.

[28]  G. Calothy,et al.  The noncatalytic TrkCNC2 receptor is cleaved by metalloproteases upon neurotrophin-3 stimulation , 2003, Oncogene.

[29]  E. Harlow,et al.  The retinoblastoma tumour suppressor in development and cancer , 2002, Nature Reviews Cancer.

[30]  C. Cinti,et al.  Missing expression of pRb2/p130 in human retinoblastomas is associated with reduced apoptosis and lesser differentiation. , 2002, Investigative ophthalmology & visual science.

[31]  T. Reh,et al.  Insulin and Fibroblast Growth Factor 2 Activate a Neurogenic Program in Müller Glia of the Chicken Retina , 2002, The Journal of Neuroscience.

[32]  S. Whittemore,et al.  In Vitro Isolation and Expansion of Human Retinal Progenitor Cells , 2002, Experimental Neurology.

[33]  K. Helin,et al.  The role of p53 and pRB in apoptosis and cancer. , 2002, Current opinion in genetics & development.

[34]  Andrew J. Bannister,et al.  Rb targets histone H3 methylation and HP1 to promoters , 2001, Nature.

[35]  T. Reh,et al.  Müller glia are a potential source of neural regeneration in the postnatal chicken retina , 2001, Nature Neuroscience.

[36]  F. Christians,et al.  E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. , 2001, Genes & development.

[37]  N. Dyson,et al.  Retinoblastoma protein partners. , 2001, Advances in cancer research.

[38]  J. Harbour,et al.  Chromatin remodeling and Rb activity. , 2000, Current opinion in cell biology.

[39]  C. Peyssonnaux,et al.  Induction of Postmitotic Neuroretina Cell Proliferation by Distinct Ras Downstream Signaling Pathways , 2000, Molecular and Cellular Biology.

[40]  T. Kouzarides,et al.  Retinoblastoma protein meets chromatin. , 1999, Trends in biochemical sciences.

[41]  B. Gallie,et al.  Developmental basis of retinal-specific induction of cancer by RB mutation. , 1999, Cancer research.

[42]  A. Kastner,et al.  Transient accumulation of retinoblastoma/E2F-1 protein complexes correlates with the onset of neuronal differentiation in the developing quail neural retina. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[43]  A. Berns,et al.  p107 is a suppressor of retinoblastoma development in pRb-deficient mice. , 1998, Genes & development.

[44]  T. Jacks,et al.  Loss of Rb activates both p53‐dependent and independent cell death pathways in the developing mouse nervous system. , 1996, The EMBO journal.

[45]  A. Pierani,et al.  Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein , 1995, Molecular and cellular biology.

[46]  T. Schwartz,et al.  Retinoblastoma. Cell of origin. , 1995, Archives of ophthalmology.

[47]  R. Weinberg,et al.  The retinoblastoma protein and cell cycle control , 1995, Cell.

[48]  S. Saule,et al.  Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina. , 1993, Molecular and cellular biology.

[49]  G. Ramı́rez,et al.  Spatial and Temporal Patterns of Neurogenesis in the Chick Retina , 1991, The European journal of neuroscience.

[50]  A. Eychène,et al.  A novel oncogene related to c‐mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus. , 1988, The EMBO journal.

[51]  W. Lee,et al.  Human retinoblastoma susceptibility gene: cloning, identification, and sequence , 1987, Science.

[52]  K. Holbrook,et al.  Label-retaining cells in human embryonic and fetal epidermis. , 1987, The Journal of investigative dermatology.

[53]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[54]  G. Calothy,et al.  Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses. , 1980, Cold Spring Harbor symposia on quantitative biology.