Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo

A microtubule arm regulates cell–cell repulsion, pointing hemocytes in opposite directions when they contact each other in Drosophila embryos.

[1]  C. Turck,et al.  Drosophila RhoGEF2 Associates with Microtubule Plus Ends in an EB1-Dependent Manner , 2004, Current Biology.

[2]  F. Perez,et al.  Dynamic Localization of CLIP-170 to Microtubule Plus Ends Is Coupled to Microtubule Assembly , 1999, The Journal of cell biology.

[3]  A. Jacinto,et al.  Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster , 2006, The Journal of cell biology.

[4]  Damian Brunner,et al.  Transiently reorganized microtubules are essential for zippering during dorsal closure in Drosophila melanogaster. , 2006, Developmental cell.

[5]  Roberto Mayor,et al.  Contact Inhibition of Locomotion in vivo controls neural crest directional migration , 2008, Nature.

[6]  A. Hyman,et al.  Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation , 2001, Current Biology.

[7]  Marileen Dogterom,et al.  Dynamic instability of microtubules is regulated by force , 2003, The Journal of cell biology.

[8]  I. Gelfand,et al.  Dynamics of contacts between lamellae of fibroblasts: essential role of the actin cytoskeleton. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Paul Martin,et al.  Fascin is required for blood cell migration during Drosophila embryogenesis , 2009, Development.

[10]  Brian Stramer,et al.  Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration , 2005, The Journal of cell biology.

[11]  G. Bokoch,et al.  Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton , 2002, Nature Cell Biology.

[12]  S. Dedhar,et al.  NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3β and Functions of the Microtubule Plus End Binding Protein APC , 2004, Neuron.

[13]  C. McCaig,et al.  Growth cone steering by a physiological electric field requires dynamic microtubules, microfilaments and Rac-mediated filopodial asymmetry , 2006, Journal of Cell Science.

[14]  M. Schachner,et al.  Microtubule reorganization is obligatory for growth cone turning. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Benjamin Geiger,et al.  How do microtubules guide migrating cells? , 2002, Nature Reviews Molecular Cell Biology.

[16]  F. Perez,et al.  CLIP-170 Highlights Growing Microtubule Ends In Vivo , 1999, Cell.

[17]  I. Gelfand,et al.  Contact interactions between epitheliocytes and fibroblasts: Formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A. Brand,et al.  GFP in Drosophila. , 1995, Trends in genetics : TIG.

[19]  James Q. Zheng,et al.  Growth Cone Turning Induced by Direct Local Modification of Microtubule Dynamics , 2002, The Journal of Neuroscience.

[20]  Stephen S. Gisselbrecht,et al.  New fluorescent protein reporters for use with the drosophila gal4 expression system and for vital detection of balancer chromosomes , 2002, Genesis.

[21]  Paul Martin,et al.  Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure , 2008, Development.

[22]  A. Coulson,et al.  A functional genomic analysis of cell morphology using RNA interference , 2003, Journal of biology.

[23]  Y. Zheng,et al.  Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases* , 1998, The Journal of Biological Chemistry.

[24]  K. VijayRaghavan,et al.  Real‐time imaging of morphogenetic movements in drosophila using Gal4‐UAS‐driven expression of GFP fused to the actin‐binding domain of moesin , 2002, Genesis.

[25]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. , 1953, Experimental cell research.

[26]  Chris Q Doe,et al.  Microtubule-induced cortical cell polarity. , 2007, Genes & development.

[27]  A. Jacinto,et al.  Drosophila melanogaster embryonic haemocytes: masters of multitasking , 2007, Nature Reviews Molecular Cell Biology.

[28]  M. Ahmadian,et al.  Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules* , 2001, The Journal of Biological Chemistry.

[29]  D. V. Vactor,et al.  The Microtubule Plus End Tracking Protein Orbit/MAST/CLASP Acts Downstream of the Tyrosine Kinase Abl in Mediating Axon Guidance , 2004, Neuron.

[30]  S. Bagrodia,et al.  The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells* , 1999, The Journal of Biological Chemistry.

[31]  K. Broadie,et al.  The Hereditary Spastic Paraplegia Gene, spastin, Regulates Microtubule Stability to Modulate Synaptic Structure and Function , 2004, Current Biology.

[32]  U. Tepass,et al.  Function of Rho GTPases in embryonic blood cell migration in Drosophila , 2004, Journal of Cell Science.

[33]  T. Shaw,et al.  Gene induction following wounding of wild‐type versus macrophage‐deficient Drosophila embryos , 2008, EMBO reports.

[34]  Irina Kaverina,et al.  Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation , 1999, The Journal of cell biology.

[35]  C. Sunkel,et al.  The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state. , 2007, Cell motility and the cytoskeleton.

[36]  J. Husson,et al.  Force-generation and dynamic instability of microtubule bundles , 2008, Proceedings of the National Academy of Sciences.

[37]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. II. Monolayering of fibroblasts. , 1954, Experimental cell research.

[38]  R. Vale,et al.  Molecular requirements for actin-based lamella formation in Drosophila S2 cells , 2003, The Journal of cell biology.

[39]  Kenneth M. Yamada,et al.  One-dimensional topography underlies three-dimensional fibrillar cell migration , 2009, The Journal of cell biology.

[40]  N. Perrimon,et al.  The PDGF/VEGF receptor controls blood cell survival in Drosophila. , 2004, Developmental cell.