An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors.
暂无分享,去创建一个
Chen-Yi Chiang | Jiun-Bo Chen | P. C. Wu | A. F. Hung | T. Chang | Rong-Long Pan | Y. Shiung | Donic Chien-Sheng Lu | A. Hung | Yu-Yu Shiung
[1] P. Mwinzi,et al. CD23-Bound IgE Augments and Dominates Recall Responses through Human Naive B Cells , 2010, The Journal of Immunology.
[2] Hwan-You Chang,et al. Unique Epitopes on CεmX in IgE–B Cell Receptors Are Potentially Applicable for Targeting IgE-Committed B Cells , 2010, The Journal of Immunology.
[3] R. Katz,et al. Effects of omalizumab in patients with food allergy. , 2010, Allergy and asthma proceedings.
[4] J. Bousquet,et al. The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update. , 2009, Respiratory medicine.
[5] B. Sutton,et al. IgE in allergy and asthma today , 2008, Nature Reviews Immunology.
[6] J. Byrd,et al. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines. , 2008, Blood.
[7] D. Conrad,et al. CD23: An overlooked regulator of allergic disease , 2007, Current allergy and asthma reports.
[8] J. Byrd,et al. Phase 1 Study of Lumiliximab with Detailed Pharmacokinetic and Pharmacodynamic Measurements in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia , 2007, Clinical Cancer Research.
[9] P. Lipsky,et al. The Low Affinity IgE Receptor (CD23) Is Cleaved by the Metalloproteinase ADAM10* , 2007, Journal of Biological Chemistry.
[10] C. Hsu,et al. Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases. , 2007, Advances in immunology.
[11] Anne E. Shelburne,et al. In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesis. , 2006, Cellular immunology.
[12] T. Chang,et al. Anti-IgE as a mast cell-stabilizing therapeutic agent. , 2006, The Journal of allergy and clinical immunology.
[13] B. Lanier. Unanswered clinical questions and speculation about the role of anti-immunoglobulin E in atopic and nonatopic disease. , 2006, Allergy and asthma proceedings.
[14] M. Spellman,et al. Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects. , 2005, The Journal of allergy and clinical immunology.
[15] Rebecca L. Beavil,et al. The structure of human CD23 and its interactions with IgE and CD21 , 2005, The Journal of experimental medicine.
[16] J. Bousquet,et al. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. , 2005, The Journal of allergy and clinical immunology.
[17] Rosalind Wright,et al. Population disparities in asthma. , 2005, Annual review of public health.
[18] G. B. Wisdom,et al. Conjugation of antibodies to horseradish peroxidase. , 2005, Methods in molecular biology.
[19] A. Togias,et al. Omalizumab-induced reductions in mast cell FcεRI expression and function , 2004 .
[20] T. Casale,et al. Rationale for new treatments aimed at IgE immunomodulation. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[21] S. Salminen,et al. The allergy epidemic extends beyond the past few decades , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[22] H. Towbin,et al. Can anti-IgE be used to treat allergy? , 2004, Springer Seminars in Immunopathology.
[23] W. Busse,et al. Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial. , 2003, The Journal of allergy and clinical immunology.
[24] W. Lumry,et al. Omalizumab is effective in the long-term control of severe allergic asthma. , 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[25] H. Niiro,et al. Decision making in the immune system: Regulation of B-cell fate by antigen-receptor signals , 2002, Nature Reviews Immunology.
[26] M. Brigham-Burke,et al. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti‐interleukin‐4 antibody with therapeutic potential in asthma , 2002, Clinical and experimental immunology.
[27] M. Reff,et al. Anti-CD23 monoclonal antibody inhibits germline Cε transcription in B cells , 2002 .
[28] P. Brams,et al. In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain. , 2000, International journal of immunopharmacology.
[29] T. Chang. The pharmacological basis of anti-IgE therapy , 2000, Nature Biotechnology.
[30] Salvi Ss,et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. , 1999 .
[31] R. Bush,et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. , 1999, The New England journal of medicine.
[32] J. Kinet,et al. High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I. , 1996, Journal of immunology.
[33] A. Beavil,et al. Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[34] J. Mermod,et al. Inhibition of human interleukin 4‐induced IgE synthesis by a subset of anti‐CD23/FcϵRII monoclonal antibodies , 1990 .
[35] D. Conrad. FcεRII/CD23: The Low Affinity Receptor for IgE , 1990 .