Proteomics: a major new technology for the drug discovery process.

[1]  C. Dykes,et al.  Genes, disease and medicine. , 2003, British journal of clinical pharmacology.

[2]  N. Anderson,et al.  Proteome and proteomics: New technologies, new concepts, and new words , 1998, Electrophoresis.

[3]  S. Gygi,et al.  Electrophoresis combined with novel mass spectrometry techniques: Powerful tools for the analysis of proteins and proteomes , 1998, Electrophoresis.

[4]  M Schena,et al.  Microarrays: biotechnology's discovery platform for functional genomics. , 1998, Trends in biotechnology.

[5]  David Housman,et al.  Why pharmacogenomics? Why now? , 1998, Nature Biotechnology.

[6]  S. Crooke Optimizing the impact of genomics on drug discovery and development , 1998, Nature Biotechnology.

[7]  J. Eddes,et al.  Two‐dimensional gel database of human breast carcinoma cell expressed proteins: An update , 1998, Electrophoresis.

[8]  D. Arnott,et al.  An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy. , 1998, Analytical biochemistry.

[9]  A. Persidis The business of pharmacogenomics , 1998, Nature Biotechnology.

[10]  R. Parekh,et al.  Post-translational modification of proteins and the discovery of new medicine. , 1997, Current opinion in biotechnology.

[11]  S. Rastan,et al.  Functional genomics: going forwards from the databases. , 1997, Current opinion in genetics & development.

[12]  F. Guengerich,et al.  Expression of drug-metabolizing enzymes. , 1997, Current opinion in biotechnology.

[13]  T. Ørntoft,et al.  Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. , 1997, Cancer research.

[14]  H. Guchelaar,et al.  Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach. , 1997, Cancer treatment reviews.

[15]  K. Williams,et al.  Analysis of differential protein expression in normal and neoplastic human breast epithelial cell lines , 1997, Electrophoresis.

[16]  K. Ghoshal,et al.  An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. , 1997, Biochemical pharmacology.

[17]  P. James,et al.  Of genomes and proteomes. , 1997, Biochemical and biophysical research communications.

[18]  Slobodan Petar Rendic,et al.  Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. , 1997, Drug metabolism reviews.

[19]  A. Schaeffer,et al.  Two-dimensional gel electrophoresis detects prostate-specific antigen-alpha1-antichymotrypsin complex in serum but not in prostatic fluid. , 1997, Clinical chemistry.

[20]  P. Weigel,et al.  The human asialoglycoprotein receptor is palmitoylated and fatty deacylation causes inactivation of state 2 receptors. , 1996, Biochemical and biophysical research communications.

[21]  H. Kato,et al.  Detection of polypeptides associated with the histopathological differentiation of primary lung carcinoma. , 1995, British Journal of Cancer.

[22]  L. Huber Mapping cells and sub‐cellular organelles on 2‐D gels: ‘new tricks for an old horse’ , 1995, FEBS letters.

[23]  G. Hansson,et al.  The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small intestine. , 1995, The Biochemical journal.

[24]  S. Carroll,et al.  Expression of an endogenous asialoglycoprotein receptor in a human intestinal epithelial cell line, Caco-2. , 1994, Biochimica et biophysica acta.

[25]  D. Wall,et al.  Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains , 1983, The Journal of cell biology.

[26]  G. Ramsay DNA chips: State-of-the art , 1998, Nature Biotechnology.

[27]  B. Hambly,et al.  Separation of tumor necrosis factor α isoforms by two‐dimensional polyacrylamide gel electrophoresis , 1997, Electrophoresis.

[28]  J. Seilhamer,et al.  A comparison of selected mRNA and protein abundances in human liver , 1997, Electrophoresis.

[29]  R. Moritz,et al.  A two‐dimensional gel database of human colon carcinoma proteins , 1997, Electrophoresis.

[30]  V. Preedy,et al.  Protein profiling in cardiac tissue in response to the chronic effects of alcohol , 1997, Electrophoresis.

[31]  Katherine B. Williams,et al.  A two‐dimensional electrophoresis database of human breast epithelial cell proteins , 1997, Electrophoresis.

[32]  D. Hochstrasser,et al.  Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots , 1997, Electrophoresis.

[33]  G. Corthals,et al.  Prefractionation of protein samples prior to two‐dimensional electrophoresis , 1997, Electrophoresis.

[34]  D. Hochstrasser,et al.  Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it. , 1996, Biotechnology & genetic engineering reviews.

[35]  R. Kuick,et al.  Two‐dimensional separations of the genome and proteome of neuroblastoma cells , 1996, Electrophoresis.

[36]  D. Hochstrasser,et al.  Human blood platelet protein map established by two‐dimensional polyacrylamide gel electrophoresis , 1995, Electrophoresis.

[37]  E A Khairallah,et al.  Differential detergent fractionation of isolated hepatocytes: Biochemical, immunochemical and two‐dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments , 1994, Electrophoresis.