A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer’s disease model
暂无分享,去创建一个
C. Kaether | S. Geng | Bin Wang | Bing Wu | Yanxin Hu | Yang Yu | Shuang Wang | Xiaoping Xie | Xiaolin Li | Hanqian Xu | Dongmei Wang | Chaofan Li | Lianfeng Zhang | Li Zhang
[1] G. Landreth,et al. Evidence for impaired amyloid β clearance in Alzheimer's disease , 2013, Alzheimer's Research & Therapy.
[2] Xiuping Liu,et al. DNA and protein co-administration induces tolerogenic dendritic cells through DC-SIGN mediated negative signals , 2013, Human vaccines & immunotherapeutics.
[3] C. Lemere,et al. MER5101, a Novel Aβ1-15:DT Conjugate Vaccine, Generates a Robust Anti-Aβ Antibody Response and Attenuates Aβ Pathology and Cognitive Deficits in APPswe/PS1ΔE9 Transgenic Mice , 2013, The Journal of Neuroscience.
[4] R. Rosenberg,et al. A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease , 2013, Journal of Neuroimmunology.
[5] Bin Wang,et al. Treg Cell Resistance to Apoptosis in DNA Vaccination for Experimental Autoimmune Encephalomyelitis Treatment , 2012, PloS one.
[6] Yuzhang Wu,et al. Caveolin-1–Mediated Negative Signaling Plays a Critical Role in the Induction of Regulatory Dendritic Cells by DNA and Protein Coimmunization , 2012, The Journal of Immunology.
[7] Lianfeng Zhang,et al. Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease , 2012, Pharmacology Biochemistry and Behavior.
[8] K. Blennow,et al. Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study , 2012, The Lancet Neurology.
[9] K. Mills,et al. TLR-dependent T cell activation in autoimmunity , 2011, Nature Reviews Immunology.
[10] W. Klunk. Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia , 2011, Neurobiology of Aging.
[11] G. Puras,et al. Encapsulation of Aβ(1-15) in PLGA microparticles enhances serum antibody response in mice immunized by subcutaneous and intranasal routes. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[12] T. L. Taylor,et al. Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence , 2011, Journal of Neuroinflammation.
[13] L. Mucke,et al. Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice , 2011, The Journal of Neuroscience.
[14] M. Staufenbiel,et al. The Second-Generation Active Aβ Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects , 2011, The Journal of Neuroscience.
[15] E. Oviedo-Orta,et al. Progress in understanding adjuvant immunotoxicity mechanisms. , 2011, Toxicology letters.
[16] J. Libbey,et al. Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines. , 2011, Vaccine.
[17] P. Livingston,et al. Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer , 2011, Expert review of vaccines.
[18] Todd E. Golde,et al. Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift , 2011, Neuron.
[19] J. Buckner. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases , 2010, Nature Reviews Immunology.
[20] E. Siemers,et al. Solanezumab was safe and well-tolerated for Asian patients with mild-to-moderate Alzheimer's disease in a multicenter, randomized, open-label, multi-dose study , 2010, Alzheimer's & Dementia.
[21] Qinying Zhao,et al. Safety and pharmacokinetics following a single 10-minute intravenous infusion of the anti-amyloid mAb ponezumab (PF-04360365) in patients with mild to moderate Alzheimer's disease , 2010, Alzheimer's & Dementia.
[22] R. Sperling,et al. A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease , 2010, Alzheimer disease and associated disorders.
[23] W. Schmidt,et al. Development of AFFITOPE vaccines for Alzheimer’s disease (AD) — From concept to clinical testing , 2009 .
[24] C. Colton,et al. Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice. , 2009, CNS & neurological disorders drug targets.
[25] L. Mucke,et al. Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice , 2009, The Journal of Neuroscience.
[26] Jianjun Chen,et al. A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice , 2009, BMC infectious diseases.
[27] V. Vasilevko,et al. Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice , 2008, Journal of Neuroinflammation.
[28] R. Nitsch,et al. Targeting β-amyloid pathology in Alzheimer’s disease with Aβ immunotherapy , 2008, Neurotherapeutics.
[29] Lin Zhao,et al. Induction of Adaptive T Regulatory Cells That Suppress the Allergic Response by Coimmunization of DNA and Protein Vaccines1 , 2008, The Journal of Immunology.
[30] M. Battaglia,et al. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans , 2007, Nature Reviews Immunology.
[31] Changcai Wang,et al. Site-specific UBITh® amyloid-β vaccine for immunotherapy of Alzheimer's disease , 2007 .
[32] R. Ferrante,et al. Conformation-sensitive Antibodies against Alzheimer Amyloid-β by Immunization with a Thioredoxin-constrained B-cell Epitope Peptide* , 2007, Journal of Biological Chemistry.
[33] D. Wilcock,et al. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. , 2007, Neuroscience.
[34] Hartwig Wolburg,et al. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology , 2006, EMBO reports.
[35] C. Lemere,et al. Short Amyloid-β (Aβ) Immunogens Reduce Cerebral Aβ Load and Learning Deficits in an Alzheimer's Disease Mouse Model in the Absence of an Aβ-Specific Cellular Immune Response , 2006, The Journal of Neuroscience.
[36] Alun Williams,et al. Interferon-γ increases neuronal death in response to amyloid-β1-42 , 2006, Journal of Neuroinflammation.
[37] S. Barger,et al. Journal of Neuroinflammation Interleukin-1 Mediates Alzheimer and Lewy Body Pathologies , 2022 .
[38] Fuchun Zhang,et al. Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines. , 2005, Virology.
[39] Nick C Fox,et al. Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial , 2005, Neurology.
[40] Kefei Chen,et al. Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease , 2005, Genes, brain, and behavior.
[41] E. Masliah,et al. Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease , 2005, Science.
[42] L. Jenkins,et al. Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD , 2005, Neurology.
[43] Zheng Feng,et al. Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease , 2004, Journal of pineal research.
[44] Manuel Buttini,et al. Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance. , 2004, The American journal of pathology.
[45] Dave Morgan,et al. Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation , 2003, The Journal of Neuroscience.
[46] R. Motter,et al. Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[47] G. Comi,et al. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. , 2003, Brain : a journal of neurology.
[48] J. Trojanowski,et al. IMPY: an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques , 2002, Brain Research.
[49] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[50] Xin Wu,et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model , 2002, Nature Neuroscience.
[51] David J. Cummins,et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[52] R. Motter,et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.
[53] Q. Chuan,et al. Establishment of the transgenic model of Alzheimers disease , 2000, Neurobiology of Aging.
[54] Anthony Gamst,et al. Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial , 2000 .
[55] R. Veerhuis,et al. Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor , 1999, Experimental Neurology.
[56] R. Motter,et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.
[57] C. Kensil,et al. QS-21: a water-soluble triterpene glycoside adjuvant. , 1998, Expert opinion on investigational drugs.
[58] Hervé Groux,et al. A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.
[59] J. M. Koolhaas,et al. Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation , 1996, Physiology & Behavior.
[60] H. Weiner,et al. Antigen‐specific TGF‐β1 Secretion with Bovine Myelin Oral Tolerization in Multiple Sclerosis , 1996, Annals of the New York Academy of Sciences.
[61] K. Liang,et al. Involvement of hippocampal NMDA and AMPA receptors in acquisition, formation and retrieval of spatial memory in the Morris water maze. , 1994, The Chinese journal of physiology.
[62] C. Lallemand,et al. Adjuvant activity of cytokines. , 2010, Methods in molecular biology.
[63] T. Nomura,et al. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. , 2006, Current topics in microbiology and immunology.