Effect of inhibition of extracellular signal‐regulated kinase on relaxations to β‐adrenoceptor agonists in porcine isolated blood vessels

Background and purpose:  Stimulation of vascular β‐adrenoceptors causes vasodilatation through activation of adenylyl cyclase (AC) and plasma membrane potassium channels, and β‐adrenoceptors have been linked to activation of extracellular signal‐regulated kinase (ERK) mitogen‐activated protein kinase in various cell lines. However, how these findings relate to functional responses in intact tissues is largely unknown. The aim of this study, therefore, was to investigate the role of ERK in β‐adrenoceptor‐induced vasodilatation.

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