The vanishing twin: a review.

This article reviews the scientific literature discussing the vanishing twin phenomenon. Information pertaining to frequency, aetiology, and potential complications, as well as the impact of sonographic technology on our growing understanding of the events in early multiple pregnancy is provided.

[1]  S. Levi Ultrasonic assessment of the high rate of human multiple pregnancy in the first trimester , 1976, Journal of clinical ultrasound : JCU.

[2]  R. Berkowitz,et al.  The current status of multifetal pregnancy reduction. , 1996, American journal of obstetrics and gynecology.

[3]  J. Hustin,et al.  Clinical and Morphologic Aspects of the Vanishing Twin Phenomenon , 1988, Obstetrics and gynecology.

[4]  H. Finberg,et al.  Ultrasound observations in multiple gestation with first trimester bleeding: the blighted twin. , 1979, Radiology.

[5]  M. Melnick BRAIN DAMAGE IN SURVIVOR AFTER IN-UTERO DEATH OF MONOZYGOUS CO-TWIN , 1977, The Lancet.

[6]  H. Soma,et al.  Outcome of the surviving cotwin of a fetus papyraceus or of a dead fetus. , 1986, Acta geneticae medicae et gemellologiae.

[7]  L. Keith,et al.  The vanishing twin. , 1982, Acta geneticae medicae et gemellologiae.

[8]  G. Pilu,et al.  Sonography of pregnancies with first‐trimester bleeding and a viable embryo: a study of prognostic indicators by logistic regression analysis , 1996, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[9]  R. Edwards,et al.  Observations on 767 clinical pregnancies and 500 births after human in-vitro fertilization. , 1986, Human reproduction.

[10]  D. Nyberg,et al.  Sirenomelia associated with a "vanishing twin". , 1991, Teratology.

[11]  H. Hoyme,et al.  Vascular etiology of disruptive structural defects in monozygotic twins. , 1981, Pediatrics.

[12]  I. Blickstein,et al.  The First‐Trimester Growth‐Discordant Twin: An Ominous Prenatal Finding , 1994, Obstetrics and gynecology.

[13]  R. Jewelewicz,et al.  The vanishing sac syndrome. Ultrasound evidence of pregnancy failure in multiple gestations, induced and spontaneous. , 1986, The Journal of reproductive medicine.

[14]  R. Dickey,et al.  Incidence and significance of unequal gestational sac diameter or embryo crown-rump length in twin pregnancy. , 1992, Human reproduction.

[15]  J. Caines,et al.  SONAR EVIDENCE OF EARLY PREGNANCY FAILURE IN PATIENTS WITH TWIN CONCEPTIONS , 1977, British journal of obstetrics and gynaecology.

[16]  Z. Blumenfeld,et al.  Spontaneous fetal reduction in multiple gestations assessed by transvaginal ultrasound , 1992, British journal of obstetrics and gynaecology.

[17]  T. Koyanagi,et al.  The prognosis of multiple pregnancy assessed by ultrasonic tomography. , 1981, Acta obstetrica et gynaecologica Japonica.

[18]  M. Seoud,et al.  Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: the Norfolk experience. , 1992, Fertility and sterility.

[19]  R. Rawlins,et al.  Human chorionic gonadotropin rise in normal and vanishing twin pregnancies. , 1991, Fertility and sterility.

[20]  L. Hellman,et al.  Ultrasonic diagnosis of embryonic malformations. , 1973, American journal of obstetrics and gynecology.

[21]  H. Landy,et al.  The "vanishing twin": ultrasonographic assessment of fetal disappearance in the first trimester. , 1986, American journal of obstetrics and gynecology.

[22]  J. Itskovitz‐Eldor,et al.  The natural history of multiple pregnancies after assisted reproduction: is spontaneous fetal demise a clinically significant phenomenon? , 1993, Fertility and sterility.

[23]  A. Yajima,et al.  Funipuncture for Evaluation of Hematologic and Coagulation Indices in the Surviving Twin Following Co‐Twin's Death , 1994, Obstetrics and gynecology.

[24]  R. Felder,et al.  Vaginal Sonography Findings and hCG Dynamics of Early Intrauterine and Tubal Pregnancies , 1990, Obstetrics and gynecology.

[25]  Dodson Mg,et al.  The vanishing twin: pathologic confirmation of an ultrasonographic phenomenon. , 1986 .

[26]  A. Kurjak,et al.  Ultrasound Diagnosis of Fetal Abnormalities in Multiple Pregnancy , 1979, Acta obstetricia et gynecologica Scandinavica.

[27]  P. Doubilet,et al.  Prognosis of first-trimester twin pregnancies: polychotomous logistic regression analysis. , 1994, Radiology.

[28]  J. Lessing,et al.  When multiple gestational sacs are seen on ultrasound, 'take-home baby' rate improves with in-vitro fertilization. , 1993, Human reproduction.

[29]  P. Doubilet,et al.  Outcome of twin gestations following sonographic demonstration of two heart beats in the first trimester , 1993, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[30]  D. de Ziegler,et al.  Evolution of a highly successful in vitro fertilization-embryo transfer program. , 1987, Fertility and sterility.

[31]  G. Goldman,et al.  The vanishing fetus. A report of 17 cases of triplets and quadruplets. , 1989, Journal of perinatal medicine.

[32]  E. Jauniaux,et al.  Pathologic examination of placentas from singleton and twin pregnancies obtained after in vitro fertilization and embryo transfer. , 1993, Pediatric pathology.

[33]  A. Nerlich,et al.  [Placental findings in "vanishing twins"]. , 1992, Geburtshilfe und Frauenheilkunde.

[34]  P. Belfrage,et al.  Routine or Selective Ultrasound Examinations in Early Pregnancy , 1987, Obstetrics and gynecology.

[35]  K. Benirschke,et al.  The Recognition And Significance Of The Vanishing Twin , 1989, The Journal of the American Board of Family Medicine.

[36]  H. M. Chambers,et al.  A normal 46,XX infant with a 46,XX/ 69.XXY placenta: A major contribution to the placenta is from a resorbed twin , 1991, Prenatal diagnosis.

[37]  A. Sampson,et al.  Vanishing twins: the frequency of spontaneous fetal reduction of a twin pregnancy , 1992, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[38]  J. Grudzinskas,et al.  ULTRASONIC ASSESSMENT OF COMPLICATIONS DURING FIRST TRIMESTER OF PREGNANCY , 1987, The Lancet.

[39]  T. Miura,et al.  Seasonality in early loss of one fetus among twin pregnancies. , 1990, Acta geneticae medicae et gemellologiae.

[40]  L. Shulman,et al.  Resorbed co‐twin as an explanation for discrepant chorionic villus results: Non‐mosaic 47,XX, +16 in villi (direct and culture) with normal (46,XX) amniotic fluid and neonatal blood , 1989, Prenatal diagnosis.

[41]  S. Antonarakis,et al.  The vanishing twin: An explanation for discordance between chorionic villus karyotype and fetal phenotype , 1991, Prenatal diagnosis.

[42]  S. Stone,et al.  Outcome of triplet pregnancies after assisted reproductive techniques: how frequent are the vanishing embryos? , 1995, Fertility and Sterility.

[43]  R. Dickey,et al.  The probability of multiple births when multiple gestational sacs or viable embryos are diagnosed at first trimester ultrasound. , 1990, Human reproduction.

[44]  J. Nijhuis,et al.  Trisomy 16 confined to the placenta , 1992, Prenatal diagnosis.

[45]  T. Varma ULTRASOUND EVIDENCE OF EARLY PREGNANCY FAILURE IN PATIENTS WITH MULTIPLE CONCEPTIONS , 1979 .

[46]  J. Junge,et al.  The vanishing twin: morphologic and cytogenetic evaluation of an ultrasonographic phenomenon. , 1991, Gynecologic and obstetric investigation.

[47]  I. Ingemarsson,et al.  Prognosis and long-term follow-up of a twin after antenatal death of the co-twin. , 1993, The Journal of reproductive medicine.

[48]  R. Bessis,et al.  The frequency of ovular resorption during the first trimester of twin pregnancy. , 1979, Acta geneticae medicae et gemellologiae.

[49]  D. Seifer,et al.  Effects of Fetal Number and Multifetal Reduction on Length of In Vitro Fertilization Pregnancies , 1996, Obstetrics and gynecology.

[50]  J. Korenberg,et al.  Confined placental chimerism: prenatal and postnatal cytogenetic and molecular analysis, and pregnancy outcome. , 1994, American journal of medical genetics.

[51]  R. Dickey,et al.  Relationship of First‐Trimester Subchorionic Bleeding Detected by Color Doppler Ultrasound to Subchorionic Fluid, Clinical Bleeding, and Pregnancy Outcome , 1992, Obstetrics and gynecology.

[52]  E. Kohorn,et al.  Sonar in the First Trimester of Pregnancy , 1974, Obstetrics and gynecology.

[53]  A. J. Mcadams,et al.  Intrauterine disseminated intravascularcoagulation: A syndrome of multiple pregnancy with a dead twin fetus , 1969 .