Synthesis and characterisation of porous polymer microneedles

This paper presents a study on the synthesis of porous polymers with an application to microneedles. A range of Poly (ethylene glycol-co-methacrylic acid) polymers are synthesised using bulk polymerisation techniques to produce porous polymers with various strength and fluid transport characteristics. The synthesised materials are morphologically and mechanically characterised. Using different porogens in the polymer synthesis results in different mechanical strength and fluid flow characteristics. The results indicate that the fluid flow characteristics of the polymers can be sacrificed to improve strength. Optimum polymer strength can be attained by synthesising polymers with macropores that are interconnected via nanopores using the minimum amount of porogenic solvents.

[1]  Adam J. Davidson,et al.  Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood , 2009 .

[2]  R Langer,et al.  Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. , 1996, Biomaterials.

[3]  M. Allen,et al.  Microfabricated microneedles for gene and drug delivery. , 2000, Annual review of biomedical engineering.

[4]  S. Chakraborty,et al.  Development and fluidic simulation of microneedles for painless pathological interfacing with living systems , 2008 .

[5]  Z. Cui,et al.  Modelling transdermal delivery of high molecular weight drugs from microneedle systems , 2007, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[6]  Yong-Kyu Yoon,et al.  Polymer particle-based micromolding to fabricate novel microstructures , 2007, Biomedical microdevices.

[8]  Jung-Hwan Park,et al.  Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[9]  M. R. Gagné,et al.  Porogen and Cross-Linking Effects on the Surface Area, Pore Volume Distribution, and Morphology of Macroporous Polymers Obtained by Bulk Polymerization§ , 2001 .

[10]  J. Fréchet,et al.  Monolithic, “Molded”, Porous Materials with High Flow Characteristics for Separations, Catalysis, or Solid-Phase Chemistry: Control of Porous Properties during Polymerization , 1996 .

[11]  Mark G. Allen,et al.  Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  John F. Kennedy,et al.  Polymer handbook (4th Edition) , 2001 .

[13]  Mark R Prausnitz,et al.  Microneedles for transdermal drug delivery. , 2004, Advanced drug delivery reviews.

[14]  F. Švec,et al.  Porous polymer monoliths: an alternative to classical beads. , 2002, Advances in biochemical engineering/biotechnology.

[15]  M. Pishko,et al.  Solvent-Free Protein Encapsulation within Biodegradable Polymer Foams , 2004, Drug delivery.

[16]  Diganta Bhusan Das,et al.  Optimizing Microneedle Arrays to Increase Skin Permeability for Transdermal Drug Delivery , 2009, Annals of the New York Academy of Sciences.

[17]  B. W. Barry,et al.  Novel mechanisms and devices to enable successful transdermal drug delivery. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[18]  D. Sherrington,et al.  Porosity analysis of some poly(styrene/divinylbenzene)beads by nitrogen sorption and mercury intrusion porosimetry , 2000 .

[19]  F. Švec,et al.  Preparation of monolithic polymers with controlled porous properties for microfluidic chip applications using photoinitiated free‐radical polymerization , 2002 .

[20]  A. Hampl,et al.  Poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) as a mouse embryonic stem cells support , 2003 .

[21]  Mark G. Allen,et al.  Lack of pain associated with microfabricated microneedles. , 2001 .

[22]  J. Fréchet,et al.  Design of reactive porous polymer supports for high throughput bioreactors: poly(2-vinyl-4,4-dimethylazlactone-co-acrylamide- co-ethylene dimethacrylate) monoliths. , 1999, Biotechnology and bioengineering.