Molecular Regulation of Histamine Synthesis

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.

[1]  J. D. Engel,et al.  Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. , 2012, The Journal of clinical investigation.

[2]  H. White,et al.  Inhibition of histidine decarboxylase. Derivatives of histidine. , 1977, Journal of medicinal chemistry.

[3]  B. Leventhal,et al.  Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice , 2014, Neuron.

[4]  Y. Konttinen,et al.  Non-professional histamine producing cells, immune responses and autoimmunity , 2013 .

[5]  T. Wang,et al.  Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[6]  J. Wysocka,et al.  Modification of enhancer chromatin: what, how, and why? , 2013, Molecular cell.

[7]  J. Virchow,et al.  IL‐33 is a mediator rather than a trigger of the acute allergic response in humans , 2014, Allergy.

[8]  J. Nielsen,et al.  Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics. , 2014, Molecular & cellular proteomics : MCP.

[9]  V. László,et al.  Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. , 2001, Immunology letters.

[10]  F. Finkelman,et al.  Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity , 2012, Seminars in Immunopathology.

[11]  A. Caraffa,et al.  Neuropeptide substance P induces mRNA expression and secretion of CXCL8 chemokine, and HDC in human umbilical cord blood mast cells. , 2008, Clinical and investigative medicine. Medecine clinique et experimentale.

[12]  Elaine Dzierzak,et al.  GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells , 2004, The Journal of experimental medicine.

[13]  C. Akdis,et al.  Histamine-secreting microbes are increased in the gut of adult asthma patients. , 2016, The Journal of allergy and clinical immunology.

[14]  H. Sampson,et al.  Food allergy. , 2010, The Journal of allergy and clinical immunology.

[15]  Shane J. Neph,et al.  A comparative encyclopedia of DNA elements in the mouse genome , 2014, Nature.

[16]  A. Visel,et al.  Large-Scale Discovery of Enhancers from Human Heart Tissue , 2011, Nature Genetics.

[17]  C. Pittenger,et al.  Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear , 2015, Neuroscience Letters.

[18]  C. Zahnow,et al.  Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[19]  A. Nagy,et al.  The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. , 2002, The Journal of allergy and clinical immunology.

[20]  Andrew P McMahon,et al.  Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. , 2002, Developmental biology.

[21]  H. Dale,et al.  The physiological action of β‐iminazolylethylamine , 1910 .

[22]  Hua Huang,et al.  The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance , 2015, The Journal of Immunology.

[23]  Angel F. Lopez,et al.  The transcriptional program, functional heterogeneity, and clinical targeting of mast cells , 2017, The Journal of experimental medicine.

[24]  Daniel G Tenen,et al.  The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. , 2006, Genes & development.

[25]  Morgan C. Giddings,et al.  Defining functional DNA elements in the human genome , 2014, Proceedings of the National Academy of Sciences.

[26]  J. Chabon,et al.  Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates. , 2013, Immunity.

[27]  I. Nakashima,et al.  Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages , 1997, Inflammation Research.

[28]  F. Lepault,et al.  Histamine-producing cell-stimulating activity. Interleukin 3 and granulocyte-macrophage colony-stimulating factor induce de novo synthesis of histidine decarboxylase in hemopoietic progenitor cells. , 1987, Journal of immunology.

[29]  Nathaniel D. Heintzman,et al.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome , 2007, Nature Genetics.

[30]  P. Conti,et al.  Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line , 2006, Clinical and Experimental Medicine.

[31]  Dirk E. Smith,et al.  Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells1 , 2007, The Journal of Immunology.

[32]  H. Dvorak,et al.  Mast cell clones: a model for the analysis of cellular maturation , 1982, The Journal of cell biology.

[33]  R. Lockey,et al.  Anaphylaxis: a review of causes and mechanisms. , 2002, The Journal of allergy and clinical immunology.

[34]  B. Leventhal,et al.  Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice , 2014, Neuron.

[35]  P. Conti,et al.  Immunological activation of human umbilical cord blood mast cells induces tryptase secretion and interleukin-6, and histidine decarboxilase mRNA gene expression. , 2007, Pharmacological research.

[36]  L. Eckmann,et al.  Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes , 2017, The Journal of allergy and clinical immunology.

[37]  Christine Tkaczyk,et al.  Integrated signalling pathways for mast-cell activation , 2006, Nature Reviews Immunology.

[38]  S. Orkin,et al.  Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. , 1997, Blood.

[39]  Y. Sugimoto,et al.  cDNA‐derived amino acid sequence of L‐histidine decarboxylase from mouse mastocytoma P‐815 cells , 1990, FEBS letters.

[40]  A. Margulis,et al.  IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation , 2010, Inflammation Research.

[41]  J. Ryan,et al.  Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today , 2018, Front. Immunol..

[42]  A. Ichikawa,et al.  Purification and characterization of l-histidine decarboxylase from mouse mastocytoma P-815 cells. , 1990, Journal of biochemistry.

[43]  Ryan A. Flynn,et al.  A unique chromatin signature uncovers early developmental enhancers in humans , 2011, Nature.

[44]  T. Watanabe,et al.  Purification of histidine decarboxylase from the liver of fetal rats and its immunochemical and immunohistochemical characterization. , 1984, The Journal of biological chemistry.

[45]  C. Rodríguez-Caso,et al.  Green tea epigallocatechin-3-gallate is an inhibitor of mammalian histidine decarboxylase , 2003, Cellular and Molecular Life Sciences CMLS.

[46]  S. Berdnikovs,et al.  Transcriptional Heterogeneity of Mast Cells and Basophils upon Activation , 2017, The Journal of Immunology.

[47]  H. Gehring,et al.  Inhibitory and structural studies of novel coenzyme‐substrate analogs of human histidine decarboxylase , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[48]  A. Burks,et al.  Pathophysiology of food allergy. , 2011, Pediatric clinics of North America.

[49]  J. Thibault,et al.  Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. , 1997, Blood.

[50]  Yasushi Okuno,et al.  Histamine synthesis is required for granule maturation in murine mast cells , 2014, European journal of immunology.

[51]  Tyler B. Hughes,et al.  Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma. , 2015, Immunity.

[52]  B. de Las Rivas,et al.  Updated Molecular Knowledge about Histamine Biosynthesis by Bacteria , 2008, Critical reviews in food science and nutrition.

[53]  F. Finkelman,et al.  The transcription factors GATA2 and microphthalmia‐associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell–mediated anaphylaxis , 2017, The Journal of allergy and clinical immunology.

[54]  A. Patchett,et al.  Selective inhibitors of biosynthesis of aminergic neurotransmitters , 1978, Nature.

[55]  C. Pittenger,et al.  Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions , 2016, Neuropharmacology.

[56]  G. Sachs,et al.  Gastric acid secretion. , 1995, Physiological reviews.

[57]  Ruchi Gupta,et al.  The economic impact of childhood food allergy in the United States. , 2013, JAMA pediatrics.

[58]  H H Dale,et al.  The physiological action of beta-iminazolylethylamine. , 2022, The Journal of physiology.

[59]  R. Russell,et al.  Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. , 1994, Journal of the American College of Nutrition.

[60]  C. Máslinski,et al.  Histamine in C3H/W mice carrying spontaneous tumors of the mammary gland , 1991, Agents and Actions.

[61]  S. Galli,et al.  Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell- deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells , 1985, The Journal of experimental medicine.

[62]  K. Nakayama,et al.  Activation of Histidine Decarboxylase through Post-translational Cleavage by Caspase-9 in a Mouse Mastocytoma P-815* , 2007, Journal of Biological Chemistry.

[63]  A. Stark,et al.  Transcriptional enhancers: from properties to genome-wide predictions , 2014, Nature Reviews Genetics.

[64]  O. Donzé,et al.  Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. , 2007, Cytokine.

[65]  S. Galli,et al.  The pathophysiology of anaphylaxis. , 2017, The Journal of allergy and clinical immunology.

[66]  Hua Huang,et al.  A continuous T‐bet expression is required to silence the interleukin‐4‐producing potential in T helper type 1 cells , 2009, Immunology.

[67]  Y. Liu,et al.  Kruppel-like Factor 4 (KLF4) Represses Histidine Decarboxylase Gene Expression through an Upstream Sp1 Site and Downstream Gastrin Responsive Elements* , 2004, Journal of Biological Chemistry.

[68]  O. Shirihai,et al.  Mitochondrial Uncoupling Protein 2 Inhibits Mast Cell Activation and Reduces Histamine Content1 , 2009, The Journal of Immunology.

[69]  R. Young,et al.  Histone H3K27ac separates active from poised enhancers and predicts developmental state , 2010, Proceedings of the National Academy of Sciences.

[70]  K. Nakano,et al.  Regulation of histamine synthesis in mouse CD4+ and CD8+ T lymphocytes , 1999, Inflammation Research.

[71]  A. Fukamizu,et al.  Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells , 2012, Molecular medicine reports.

[72]  Michael Schwenk,et al.  Anaphylaxis , 1919, The Indian medical gazette.

[73]  K. Yamauchi,et al.  Structure of the L-histidine decarboxylase gene. , 1994, The Journal of biological chemistry.

[74]  Judy H. Cho,et al.  L-histidine decarboxylase and Tourette's syndrome. , 2010, The New England journal of medicine.

[75]  J. Bishop,et al.  Purification and characterization of histidine decarboxylase from mouse kidney. , 1986, The Biochemical journal.

[76]  W. Paul,et al.  Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype , 2001, The Journal of experimental medicine.

[77]  Łukasz M. Boryń,et al.  Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq , 2013, Science.

[78]  D. Metcalfe,et al.  Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. , 2004, Clinical immunology.

[79]  H. Komori,et al.  Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase* , 2012, The Journal of Biological Chemistry.

[80]  M. Nawijn,et al.  The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders. , 2015, Molecular immunology.

[81]  G. Csaba,et al.  Mice lacking histidine decarboxylase exhibit abnormal mast cells , 2001, FEBS letters.

[82]  M. Gurish,et al.  Granule maturation in mast cells: Histamine in control , 2014, European journal of immunology.

[83]  R. N. Brogden,et al.  Ranitidine: A Review of its Pharmacology and Therapeutic Use in Peptic Ulcer Disease and Other Allied Diseases , 1982, Drugs.

[84]  Xinzhong Dong,et al.  Different activation signals induce distinct mast cell degranulation strategies. , 2016, The Journal of clinical investigation.

[85]  I. Beales.  Gastric acid secretion. , 1997, Gut.

[86]  F. Finkelman,et al.  Pathways of anaphylaxis in the mouse. , 2002, The Journal of allergy and clinical immunology.

[87]  M. Palkovits,et al.  Gastric acid secretion in L-histidine decarboxylase-deficient mice. , 2002, Gastroenterology.

[88]  D. Katayose,et al.  Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells. , 1992, European journal of biochemistry.

[89]  C. Pittenger,et al.  High levels of histidine decarboxylase in the striatum of mice and rats , 2011, Neuroscience Letters.

[90]  C. Pittenger,et al.  Histamine modulation of the basal ganglia circuitry in the development of pathological grooming , 2017, Proceedings of the National Academy of Sciences.

[91]  Xinzhong Dong,et al.  Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions , 2014, Nature.

[92]  F. Sánchez-Jiménez,et al.  Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome. , 2013, Rheumatology.

[93]  Tariq Enver,et al.  GATA-2 regulates granulocyte-macrophage progenitor cell function. , 2008, Blood.

[94]  K. Kano,et al.  Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells. , 2006, Biochemical and biophysical research communications.

[95]  E. Furlong,et al.  Transcription factors: from enhancer binding to developmental control , 2012, Nature Reviews Genetics.

[96]  C. Akdis,et al.  Regulation of the immune response and inflammation by histamine and histamine receptors. , 2011, The Journal of allergy and clinical immunology.

[97]  S. Akira,et al.  IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[98]  G. Passalacqua,et al.  Journal of Allergy and clinical immunology , 2013 .

[99]  F. Finkelman.  Anaphylaxis: lessons from mouse models. , 2007, The Journal of allergy and clinical immunology.

[100]  K. Shirato,et al.  The mouse L-histidine decarboxylase gene: structure and transcriptional regulation by CpG methylation in the promoter region. , 2000, Nucleic acids research.

[101]  H. W. Dudley,et al.  The nature of the vaso‐dilator constituents of certain tissue extracts , 1927, The Journal of physiology.

[102]  Shoko Iwaki,et al.  Amplification of cytokine production through synergistic activation of NFAT and AP‐1 following stimulation of mast cells with antigen and IL‐33 , 2011, European journal of immunology.

[103]  E. Furlong,et al.  Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development , 2012, Nature Genetics.