DEVELOPMENT AND STUDY OF THE STABILITY OF NANOSTRUCTURED SYSTEMS CONTAINING GINGER OIL 1 DESENVOLVIMENTO

In this study, the compatibility tests between poly-ε-caprolactone (PCL) polymer and ginger essential oil, the studies on development, characterization and stability of nanostructured nanocapsule and nanoemulsion systems were performed. The importance of the choice of the polymer is essential as it plays a crucial role in the preparation of nanocapsules, protecting the active, improving the bioavailability and often reducing its toxicity. Providing safety in the pharmaceutical production. Poly-ε-caprolactone (PCL) is a biodegradable polymer widely used in nanotechnology. Ginger oil have medicinal properties that can be optimized through nanostructured systems, and can be applied as lipid nanocarrier or associated with several systems for biomedical use as antioxidant, anti-inflammatory, among others. The results indicate that PCL is compatible with the essential ginger oil, considering that no loss of mass or degradation of the polymer was observed. Therefore, nanocapsules and nanoemulsions were produced, characterized and analyzed through the stability parameters: pH, average diameter, zeta potential and polydispersion index for 60 days, stored at 2-8 °C. The average size of the systems produced was between 199 to 237nm, the average zeta potential found was between -13 and -21mV and the polydispersity index found in the range of 0.13 to 0.34. These results are in agreement with the literature for biomedical application. The nanostructured systems remained stable in the refrigerator during the period evaluated. The results obtained contribute to increase the studies of plant products in nanotechnology applied to health.