Studies on Adjuvant Chemotherapies with Mitomycin C, 5-Fluorouracil and Tegafur for Colorectal Cancer

大腸癌治癒切除におけるmitomycin C (MMC), 5-fluorouracil (5-FU), tegafur (FT)を用いた補助化学療法の有用性を検討するために,封筒法による無作為比較対象研究(1979年12月～1983年8,月)を行った.結腸癌と直腸癌に分け,結腸癌ではA群(MMC 50mg術中腸管内投与+FT 1年間投与),B群(5-FU 1,500mg術中腸管内投与+FT 1年間投与)の2群を比較し,直腸癌ではA群(MMC 10～4mg/body/回間歌投与+FT 1年間投与),B群(5-FU 250mg/body/day術後2週間連日投与+FT 1年間投与)の2群を比較した.集積症例は378例(結腸癌171例,直腸癌207例)であった.5年生存率および健存率では,結腸癌A,B群問に差は認められなかったが,直腸癌ではA群に比しB群に予後良好な傾向を認め,特に直腸癌DukesC症例においては有意差(生存率p=0.047,健存率p=0.013)を認めた.

[1]  D. Machin,et al.  A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer , 1985, The British journal of surgery.

[2]  C. Romero,et al.  Chemotherapy as an adjuvant to surgery for colorectal cancer. A follow-up report. , 1978, Archives of surgery.

[3]  B. Pasternack,et al.  Intraluminal fluorouracil chemotherapy adjunct to surgical procedures for respectable carcinoma of the colon and rectum. , 1977, Surgery, gynecology & obstetrics.

[4]  H. Leveen,et al.  Adjuvant chemotherapy in the surgical treatment of large bowel cancer , 1976, Cancer.

[5]  W. Regelson,et al.  Chemotherapy as an Adjuvant to Surgery for Colorectal Cancer , 1975, Annals of surgery.

[6]  C. Grossi,et al.  Intraluminal chemotherapy adjuvant (HN2 or 5-FU) to operation for cancer of the colon and rectum. Follow-up report of 83 cases. , 1965, Annals of surgery.

[7]  D. Slaughter,et al.  Prophylactic and Adjuvant Use of Nitrogen Mustard in the Surgical Treatment of Cancer , 1959, Annals of surgery.

[8]  M. Go,et al.  Prophylactic treatment of cancer; the use of chemotherapeutic agents to prevent tumor metastasis. , 1956 .

[9]  G. Higgins,et al.  Efficacy of prolonged intermittent therapy with combined 5‐fluorouracil and methyl‐ccnu following resection for carcinoma of the large bowel. A veterans administration surgical oncology group report , 1984, Cancer.

[10]  S. Moss,et al.  Adjuvant chemotherapy in large-bowel cancer: demonstration of effectiveness of single agent chemotherapy in a prospectively controlled,, randomized trial. , 1978, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[11]  S. Moss,et al.  Adjuvant chemotherapy with 5-fluorouracil after surgical resection of colorectal carcinoma (COG protocol 7041). A preliminary report. , 1977, American journal of surgery.