β2-GPI dampening of VWF-GPIb interaction

In this issue of Blood , Hulstein and colleagues demonstrate down-regulation of platelet GPIb interaction with von Willebrand factor (VWF) by β-2 glycoprotein I (β2 GPI) and the inhibition of this down-regulation by autoantibodies to β2 GPI that are present in patients with antiphospholipid

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