Inhibition of phenylephrine- or serotonin-induced rat aorta contractions by mexican feverfew ( Tanacetum parthenium (L.) Schultz-Bip).

Tanacetum parthenium (L.) Schultz-Bip (Asteraceae) is widely distributed around the world. This plant has been used for centuries as a traditional herbal medicine for headache treatment. Previous evidence pointed out the relationship of this plant on vasoconstriction regulation. Therefore, the aim of this work was to evaluate the T. parthenium dichloromethane crude extract, the essential oil and three isolated compounds (reynosin, santamarin, and santin) against induced contractions by phenylephrine or serotonin, using isolated rat aorta rings model. The results obtained in this work showed that Tanacetum parthenium dichloromethane extract exhibited a noncompetitive inhibitory activity against contractions induced by serotonin and phenylephrine. But the essential oil did not inhibit phenylephrine contractions. Dichloromethane extract, and the isolated compounds santin, reynosin and santamarin showed a preference to antagonize the α1-adrenergic agonist phenylephrine. These results show that there is a preference for the components of the essential oil to antagonize serotonin receptors, whereas, the extract  components show a preference for the adrenergic pathway, suggesting that both types of receptors are involved in the plant antagonistic vasoconstriction mechanism.

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