A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates.
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E. Pujadas | Jason X. Cheng | Harinder Singh | C. Spooner | Harinder Singh | Chauncey J Spooner | Peter Laslo | Elisabet Pujadas | Jason X Cheng | P. Laslo
[1] Pu Zhang,et al. Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element , 2005, Molecular and Cellular Biology.
[2] T. Graf,et al. Determinants of lymphoid-myeloid lineage diversification. , 2006, Annual review of immunology.
[3] P. Lásló,et al. Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates , 2006, Cell.
[4] Harinder Singh,et al. Contingent gene regulatory networks and B cell fate specification. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[5] Richard Dahl,et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor , 2003, Nature Immunology.
[6] A. Sharpe,et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. , 1996, Immunity.
[7] Harinder Singh,et al. Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system. , 2008, Seminars in immunology.
[8] Ignacio A. Demarco,et al. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros , 2008, Nature Immunology.
[9] Hui Zeng,et al. Transcription factor Gfi1 regulates self‐renewal and engraftment of hematopoietic stem cells , 2004, The EMBO journal.
[10] E. Bertolino,et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 , 2008, Nature Immunology.
[11] S. Ng,et al. Early hematopoietic lineage restrictions directed by Ikaros , 2006, Nature Immunology.
[12] C. Murre,et al. E protein function in lymphocyte development. , 2002, Annual review of immunology.
[13] J. Kutok,et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1 , 2004, Nature Genetics.
[14] T. Möröy,et al. Gfi1:Green Fluorescent Protein Knock-in Mutant Reveals Differential Expression and Autoregulation of the Growth Factor Independence 1 (Gfi1) Gene during Lymphocyte Development* , 2004, Journal of Biological Chemistry.
[15] Jiangwen Zhang,et al. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. , 2009, Immunity.
[16] John O. Trent,et al. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. , 2008, Immunity.
[17] Harinder Singh,et al. Assembling a gene regulatory network for specification of the B cell fate. , 2004, Developmental cell.
[18] C. Murre,et al. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade , 2001, Nature Immunology.
[19] Ellen V Rothenberg,et al. Molecular genetics of T cell development. , 2005, Annual review of immunology.
[20] E. Scott,et al. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. , 1994, Science.
[21] P. Swiatek,et al. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. , 1993, Genes & development.
[22] Lina A. Thoren,et al. Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential A Revised Road Map for Adult Blood Lineage Commitment , 2005, Cell.
[23] T. Möröy,et al. The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit+ T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus , 2003, The Journal of experimental medicine.
[24] J. Rowley,et al. Knockdown of Pu.1 by small interfering RNA in CD34+ embryoid body cells derived from mouse ES cells turns cell fate determination to pro-B cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[25] Ellen V Rothenberg,et al. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. , 2002, Immunity.
[26] T. Graf,et al. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. , 2006, Immunity.
[27] H. Singh,et al. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. , 2000, Science.
[28] Rochelle A. Diamond,et al. Notch/Delta signaling constrains reengineering of pro-T cells by PU.1 , 2006, Proceedings of the National Academy of Sciences.
[29] J. Milbrandt,et al. Thymocyte Development in Early Growth Response Gene 1-Deficient Mice1 , 2002, The Journal of Immunology.
[30] J. Walsh,et al. PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors , 1998, The EMBO journal.
[31] P. Charnay,et al. Conditional, floxed allele of the Krox20 gene , 2002, Genesis.
[32] R. Månsson,et al. E2A proteins promote development of lymphoid-primed multipotent progenitors. , 2008, Immunity.
[33] Nicola K. Wilson,et al. A Two-Step, PU.1-Dependent Mechanism for Developmentally Regulated Chromatin Remodeling and Transcription of the c-fms Gene , 2006, Molecular and Cellular Biology.
[34] Hui Zeng,et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1 , 2002, Nature Genetics.
[35] M. Simon,et al. The Transcriptional Repressor GFI-1 Antagonizes PU.1 Activity through Protein-Protein Interaction* , 2007, Journal of Biological Chemistry.
[36] A. Feeney,et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. , 1996, The EMBO journal.
[37] Harinder Singh,et al. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. , 1996, Current opinion in immunology.
[38] John Anastasi,et al. Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. , 2002, Immunity.
[39] H. Singh,et al. PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates. , 1999, Cold Spring Harbor symposia on quantitative biology.
[40] Donald Metcalf,et al. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors , 2005, The Journal of experimental medicine.
[41] Scott Cameron,et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. , 2003, Immunity.
[42] Achim Leutz,et al. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 , 2006, Nature Genetics.
[43] Hyun-Jun Lee,et al. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. , 2002, Immunity.
[44] S. Orkin,et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells , 2004, Nature.
[45] F. Camargo,et al. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c , 2009, Nature Immunology.