Detailed simulation of viral propagation in the built environment

A summary is given of the mechanical characteristics of virus contaminants and the transmission via droplets and aerosols. The ordinary and partial differential equations describing the physics of these processes with high fidelity are presented, as well as appropriate numerical schemes to solve them. Several examples taken from recent evaluations of the built environment are shown, as well as the optimal placement of sensors.

[1]  A. Jameson,et al.  Numerical solution of the Euler equations by finite volume methods using Runge Kutta time stepping schemes , 1981 .

[2]  Rainald Löhner,et al.  Optimal placement of sensors for contaminant detection based on detailed 3D CFD simulations , 2005 .

[3]  J. Peraire,et al.  Finite Element Flux-Corrected Transport (FEM-FCT) for the Euler and Navier-Stokes equations , 1987 .

[4]  John A. Burns,et al.  The Infinite-Dimensional Optimal Filtering Problem with Mobile and Stationary Sensor Networks , 2015 .

[5]  K. Benkiewicz,et al.  Two-dimensional numerical simulations of multi-headed detonations in oxygen-aluminum mixtures using an adaptive mesh refinement , 2003 .

[6]  Rainald Löhner,et al.  On the simulation of flows with violent free surface motion , 2006 .

[7]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[8]  Chao-Hsin Lin,et al.  Characterizing exhaled airflow from breathing and talking. , 2010, Indoor air.

[9]  Rainald Loehner,et al.  Application of unstructured adaptive moving body methodology to the simulation of fuel tank separation from an F-16 fighter , 1997 .

[10]  Rainald Löhner,et al.  A vectorized particle tracer for unstructured grids , 1990 .

[11]  Anthony S. Wexler,et al.  A Comprehensive Breath Plume Model for Disease Transmission via Expiratory Aerosols , 2012, PloS one.

[12]  Michael Hintermüller,et al.  Optimal Sensor Placement: A Robust Approach , 2016, SIAM J. Control. Optim..

[13]  Rainald Löhner,et al.  A coupled CFD/CSD methodology for modeling weapon detonation and fragmentation , 1999 .

[14]  Rainald Löhner,et al.  On mesh-particle techniques , 2014, CPM 2014.

[15]  Rainald Loehner,et al.  Numerical simulation of pilot/seat ejection from an F-16 , 1993 .

[16]  Rainald Loehner,et al.  Numerical simulation of a blast inside a Boeing 747 , 1993 .

[17]  Matthew T. Rice,et al.  Generating seamless surfaces for transport and dispersion modeling in GIS , 2012, GeoInformatica.

[18]  A. W. Vreman,et al.  Large-eddy simulation of a particle-laden turbulent channel flow , 2003 .

[19]  Guohui Feng,et al.  Numerical Simulation of Coughed Droplets in Conference Room , 2017 .

[20]  Suresh Menon,et al.  On the Role of Ambient Reactive Particles in the Mixing and Afterburn behind Explosive Blast Waves , 2010 .

[21]  F. Grinstein,et al.  Recent Progress on MILES for High Reynolds Number Flows , 2002 .

[22]  Naama Geva-Zatorsky,et al.  Gut Bacteria-Not for the Faint of Heart. , 2020, Cell host & microbe.

[23]  Andrew Corrigan.  SEMI-AUTOMATIC PORTING OF A GENERAL FORTRAN CFD CODE TO GPUS: THE DIFFICULT MODULES , 2011 .

[24]  Rainald Löhner,et al.  Deflated preconditioned conjugate gradient solvers for the Pressure-Poisson equation , 2008, J. Comput. Phys..

[25]  Peter F M Teunis,et al.  High infectivity and pathogenicity of influenza A virus via aerosol and droplet transmission. , 2010, Epidemics.

[26]  Rainald Löhner,et al.  Improving the speed and accuracy of projection-type incompressible flow solvers , 2006 .

[27]  Danna Zhou,et al.  d. , 1934, Microbial pathogenesis.

[28]  Rainald Löhner,et al.  Timings of FEFLO on the SGI-Ice Machines , 2011 .

[29]  Rainald Löhner,et al.  Efficient simulation of blood flow past complex endovascular devices using an adaptive embedding technique , 2005, IEEE Transactions on Medical Imaging.

[30]  William G. Lindsley,et al.  Measurements of Airborne Influenza Virus in Aerosol Particles from Human Coughs , 2010, PloS one.

[31]  Rainald Löhner,et al.  An accurate, fast, matrix-free implicit method for computing unsteady flows on unstructured grids , 2001 .

[32]  J. Eisen,et al.  2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission , 2020, mSystems.

[33]  Ravi Ramamurti,et al.  A LOAD BALANCING ALGORITHM FOR UNSTRUCTURED GRIDS , 1995 .

[34]  Eun-Ha Kim,et al.  Infection and Rapid Transmission of SARS-CoV-2 in Ferrets , 2020, Cell Host & Microbe.

[35]  H. C. Simpson.  Bubbles, drops and particles , 1980 .

[36]  Anthony S Wexler,et al.  Effect of voicing and articulation manner on aerosol particle emission during human speech , 2020, PloS one.

[37]  J. P. Boris,et al.  New insights into large eddy simulation , 1992 .

[38]  O. C. Zienkiewicz,et al.  Adaptive remeshing for compressible flow computations , 1987 .

[39]  Dylan H. Morris,et al.  Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 , 2020, The New England journal of medicine.

[40]  Ismail Celik,et al.  Quantity and Size Distribution of Cough-Generated Aerosol Particles Produced by Influenza Patients During and After Illness , 2012, Journal of occupational and environmental hygiene.

[41]  J. Koenderink.  Q… , 2014, Les noms officiels des communes de Wallonie, de Bruxelles-Capitale et de la communaute germanophone.

[42]  M. Galle,et al.  Minimization of indirect addressing for edge-based field solvers , 2002 .

[43]  R. Loudon,et al.  Droplet expulsion from the respiratory tract. , 1967, The American review of respiratory disease.

[44]  T J Cieslak,et al.  Clinical recognition and management of patients exposed to biological warfare agents. , 1997, Clinics in laboratory medicine.

[45]  Anthony S. Wexler,et al.  Aerosol emission and superemission during human speech increase with voice loudness , 2019, Scientific Reports.

[46]  Chao-Hsin Lin,et al.  Inhalation of expiratory droplets in aircraft cabins. , 2011, Indoor air.

[47]  Rainald Löhner,et al.  Numerical Simulation of Shock Interaction With a Modern Main Battlefield Tank , 1991 .

[48]  Rainald Löhner,et al.  Assessing maximum possible damage for contaminant release events , 2004 .

[49]  Rainald Löhner,et al.  Modeling of Near-Field Blast Wave Evolution , 2006 .

[51]  Ming Chia Lai,et al.  AFTERBURNING OF TNT EXPLOSIVE PRODUCTS IN AIR WITH ALUMINUM PARTICLES , 2008 .

[52]  Rainald Löhner,et al.  A Class of Matrix-Free Implicit Methods for Compressible Flows on Unstructured Grids , 2001 .

[53]  Rainald Loehner,et al.  A new ALE adaptive unstructured methodology for the simulation of moving bodies , 1994 .

[54]  K. Mengersen,et al.  Characterization of expiration air jets and droplet size distributions immediately at the mouth opening , 2008, Journal of Aerosol Science.

[55]  Rainald Löhner,et al.  Large-Eddy Simulations of a Supersonic Jet and Its Near-Field Acoustic Properties , 2009 .

[56]  Chao-Hsin Lin,et al.  Transport of expiratory droplets in an aircraft cabin. , 2011, Indoor air.

[57]  Rainald Löhner,et al.  Simulation of flows with violent free surface motion and moving objects using unstructured grids , 2007 .

[58]  Guillaume Houzeaux,et al.  Deflated preconditioned conjugate gradient solvers for the pressure‐Poisson equation: Extensions and improvements , 2011 .

[59]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[60]  Y. Li,et al.  How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve. , 2007, Indoor air.

[61]  Rainald Löhner,et al.  Running unstructured grid‐based CFD solvers on modern graphics hardware , 2011 .

[62]  Andrew Corrigan,et al.  PORTING OF FEFLO TO MULTI-GPU CLUSTERS , 2011 .

[63]  HONG LUO,et al.  A Fast, Matrix-free Implicit Method for Computing Low Mach Number Flows on Unstructured Grids , 2000 .

[64]  Rainald Löhner,et al.  Combination of body‐fitted and embedded grids for external vehicle aerodynamics , 2008 .

[65]  Rainald Loehner,et al.  Numerical simulation of blast in the World Trade Center , 1995 .

[66]  Rainald Löhner,et al.  Running unstructured grid‐based CFD solvers on modern graphics hardware , 2009 .

[67]  O. Tsang,et al.  Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study , 2020, The Lancet Infectious Diseases.

[68]  Pearu Peterson,et al.  F2PY: a tool for connecting Fortran and Python programs , 2009, Int. J. Comput. Sci. Eng..

[69]  Rainald Löhner.  Multistage explicit advective prediction for projection-type incompressible flow solvers , 2004 .

[70]  Benjamin J. Cowling,et al.  Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks , 2010, PLoS pathogens.

[71]  Rainald Löhner,et al.  VLES Study of Flow and Dispersion Patterns in Heterogeneous Urban Areas , 2006 .

[72]  J. Spurk.  Boundary Layer Theory , 2019, Fluid Mechanics.

[73]  Andrew S. Grimshaw,et al.  Revisiting sorting for GPGPU stream architectures , 2010, 2010 19th International Conference on Parallel Architectures and Compilation Techniques (PACT).

[74]  Rainald Loehner,et al.  Advances in FEFLO , 2001 .

[75]  Rainald Loehner,et al.  Numerical simulation of aircraft canopy trajectory , 1997 .

[76]  Rainald Loehner,et al.  Renumbering strategies for unstructured-grid solvers operating on shared-memory, cache-based parallel machines , 1997 .

[77]  Rainald Loehner,et al.  IMPLEMENTATION OF UNSTRUCTURED GRID GMRES+LU-SGS METHOD ON SHARED-MEMORY, CACHE-BASED PARALLEL COMPUTERS , 2000 .

[78]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[79]  Jianjian Wei,et al.  Airborne spread of infectious agents in the indoor environment , 2016, American Journal of Infection Control.

[80]  Rainald Löhner,et al.  VLES Study of Ship Stack Gas Dynamics , 2004 .

[81]  Rainald Löhner,et al.  Adaptive embedded and immersed unstructured grid techniques , 2008 .

[82]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[83]  Kerrie Mengersen,et al.  Modality of human expired aerosol size distributions , 2011 .

[84]  Rainald Löhner,et al.  Combination of Body-Fitted and Embedded Grids for External Vehicle Aerodynamics , 2007 .

[85]  Benjamin J. Cowling,et al.  Influenza Virus in Human Exhaled Breath: An Observational Study , 2008, PloS one.

[86]  Matthew T V Chan,et al.  Airflow and droplet spreading around oxygen masks: A simulation model for infection control research , 2007, American Journal of Infection Control.

[87]  F. Grinstein,et al.  Monotonically integrated large eddy simulation of free shear flows , 1999 .

[88]  Rainald Loehner,et al.  A coupled fluid/structure modeling of shock interaction with a truck , 1996 .

[89]  Nicole M. Bouvier,et al.  The coronavirus pandemic and aerosols: Does COVID-19 transmit via expiratory particles? , 2020, Aerosol science and technology : the journal of the American Association for Aerosol Research.

[90]  Rainald Löhner,et al.  Porting of an Edge-Based CFD Solver to GPUs , 2010 .

[91]  P V Nielsen,et al.  Role of ventilation in airborne transmission of infectious agents in the built environment - a multidisciplinary systematic review. , 2007, Indoor air.

[92]  G. Kampf,et al.  Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents , 2020, Journal of Hospital Infection.

[93]  Rainald Löhner,et al.  From medical images to anatomically accurate finite element grids , 2001 .

[94]  Axel E. Larreteguy,et al.  A pseudo-DNS method for the simulation of incompressible fluid flows with instabilities at different scales , 2020 .

[95]  Chao-Hsin Lin,et al.  Flow dynamics and characterization of a cough. , 2009, Indoor air.

[96]  Chandra Sekhar,et al.  Airflow Dynamics of Human Jets: Sneezing and Breathing - Potential Sources of Infectious Aerosols , 2013, PloS one.

[97]  Rainald Löhner,et al.  Edge-based finite element scheme for the Euler equations , 1994 .

[98]  Rainald Löhner,et al.  Computation of the 3-D Unsteady Flow Past Deforming Geometries , 1999 .

[99]  Chao-Hsin Lin,et al.  Optimal Sensor Placement for Airborne Contaminant Detection in an Aircraft Cabin , 2007 .

[100]  Chandra Sekhar,et al.  Airflow Dynamics of Coughing in Healthy Human Volunteers by Shadowgraph Imaging: An Aid to Aerosol Infection Control , 2012, PloS one.

[101]  A. Nicolle,et al.  Observing and quantifying airflows in the infection control of aerosol- and airborne-transmitted diseases: an overview of approaches , 2010, Journal of Hospital Infection.

[102]  J.A.M. Kuipers,et al.  Direct numerical simulation of particle mixing in dispersed gas-liquid-solid flows using a combined volume of fluid and discrete particle approach , 2006 .

[103]  Rainald Löhner,et al.  Improvements in speed for explicit, transient compressible flow solvers , 2008 .

[104]  I. Eames,et al.  Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises , 2006, Journal of Hospital Infection.

[105]  Rainald Löhner,et al.  A parallel implicit incompressible flow solver using unstructured meshes , 1993 .

[106]  Arthur Stück,et al.  Adjoint‐based design of shock mitigation devices , 2009 .

[107]  Rainald Löhner,et al.  Computational fluid dynamics of stented intracranial aneurysms using adaptive embedded unstructured grids , 2008 .

[108]  P. Jahrling,et al.  Clinical recognition and management of patients exposed to biological warfare agents. , 1997, JAMA.