Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation

[1]  Basappa,et al.  Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation , 2015, Scientific Reports.

[2]  A. Franco,et al.  Platelets at the interface of thrombosis, inflammation, and cancer. , 2015, Blood.

[3]  Basappa,et al.  Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide , 2015, PloS one.

[4]  Basappa,et al.  Biologicals, platelet apoptosis and human diseases: An outlook. , 2015, Critical reviews in oncology/hematology.

[5]  A. Assinger.  Platelets and Infection – An Emerging Role of Platelets in Viral Infection , 2014, Front. Immunol..

[6]  A. C. Vinayaka,et al.  A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis , 2014, PloS one.

[7]  M. Nayak,et al.  Aspirin Delimits Platelet Life Span by Proteasomal Inhibition , 2014, PloS one.

[8]  K. Rangappa,et al.  Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells. , 2014, European journal of medicinal chemistry.

[9]  Yu Jin,et al.  Aldose Reductase–Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets , 2014, Circulation.

[10]  D. Christiani,et al.  Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study , 2014, PloS one.

[11]  K. Girish,et al.  Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets , 2014, Journal of Thrombosis and Thrombolysis.

[12]  N. S. Gowert,et al.  Blood Platelets in the Progression of Alzheimer’s Disease , 2014, PloS one.

[13]  K. Rangappa,et al.  Tamarind seed extract mitigates the liver oxidative stress in arthritic rats. , 2014, Food & function.

[14]  K. Rangappa,et al.  Therapeutic drug-induced platelet apoptosis: an overlooked issue in pharmacotoxicology , 2014, Archives of Toxicology.

[15]  S. Sacre,et al.  Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis , 2013, Front. Immunol..

[16]  O. Karabay,et al.  Effect of severe sepsis on platelet count and their indices. , 2013, African health sciences.

[17]  Zhicheng Wang,et al.  The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis , 2013, PloS one.

[18]  K. Rangappa,et al.  Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage. , 2013, Biochemical and biophysical research communications.

[19]  H. Cinemre,et al.  Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus. , 2013, The West Indian medical journal.

[20]  T. R. Swaroop,et al.  Synthetic utility of propylphosphonic anhydride-DMSO media. An efficient one-pot three-component synthesis of 2-arylquinolines. , 2013 .

[21]  K. B. Harsha,et al.  T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols , 2012 .

[22]  G. Kouraklis,et al.  Immunological HCV-Associated Thrombocytopenia: Short Review , 2012, Clinical & developmental immunology.

[23]  C. Ruan,et al.  Cisplatin induces platelet apoptosis through the ERK signaling pathway. , 2012, Thrombosis research.

[24]  J. Freedman,et al.  Markers of platelet apoptosis: methodology and applications , 2012, Journal of Thrombosis and Thrombolysis.

[25]  M. Alexis,et al.  Isoxazole substituted chromans against oxidative stress-induced neuronal damage. , 2011, Bioorganic & medicinal chemistry.

[26]  B. S. Vishwanath,et al.  The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin , 2011, Annals of Hematology.

[27]  H. Falet,et al.  Novel clearance mechanisms of platelets , 2010, Current opinion in hematology.

[28]  Annamaria Lilienkampf,et al.  Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development. , 2010, Journal of medicinal chemistry.

[29]  Deepak L. Bhatt,et al.  Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis , 2010, Journal of thrombosis and haemostasis : JTH.

[30]  J. Weisel,et al.  Antioxidants change platelet responses to various stimulating events. , 2009, Free radical biology & medicine.

[31]  G. Stack,et al.  Drug-induced thrombocytopenia. , 2009, Archives of pathology & laboratory medicine.

[32]  I. Fearon,et al.  Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. , 2009, Journal of molecular and cellular cardiology.

[33]  B. Kile,et al.  The role of the intrinsic apoptosis pathway in platelet life and death , 2009, Journal of thrombosis and haemostasis : JTH.

[34]  B. Kim,et al.  Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses , 2008, Bioorganic & Medicinal Chemistry Letters.

[35]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[36]  M. Rizzi,et al.  Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties. , 2008, Journal of medicinal chemistry.

[37]  Donghui Zhou,et al.  Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions* , 2008, Journal of Biological Chemistry.

[38]  G. Salido,et al.  Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets , 2007, Journal of thrombosis and haemostasis : JTH.

[39]  G. Salido,et al.  Thrombin-induced caspases 3 and 9 translocation to the cytoskeleton is independent of changes in cytosolic calcium in human platelets. , 2006, Blood cells, molecules & diseases.

[40]  G. FitzGerald,et al.  Oxidative Stress and Cardiovascular Injury: Part I: Basic Mechanisms and In Vivo Monitoring of ROS , 2003, Circulation.

[41]  R. Nieuwland,et al.  Microparticles in cardiovascular diseases. , 2003, Cardiovascular research.

[42]  J. Barrow,et al.  Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1). , 2002, Bioorganic & medicinal chemistry letters.

[43]  J. Seghatchian,et al.  Platelet storage lesion and apoptosis: are they related? , 2001, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[44]  G. Yen,et al.  Antioxidant actions of du-zhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules. , 2000, Life sciences.

[45]  G. Miotto,et al.  Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. , 1999, Biophysical journal.

[46]  J. Terao,et al.  HPLC method for evaluation of the free radical-scavenging activity of foods by using 1,1-diphenyl-2-picrylhydrazyl. , 1998, Bioscience, biotechnology, and biochemistry.

[47]  井内 陽子.  Valinomycin Induces Apoptosis of Ascites Hepatoma Cells(AH-130) in Relation to Mitochondrial Membrane Potential , 1998 .

[48]  C. Franceschi,et al.  JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis , 1997, FEBS letters.

[49]  D. Ojcius,et al.  Cytolysis mediated by ionophores and pore‐forming agents: role of intracellular calcium in apoptosis , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  H. Lardy,et al.  A23187: a divalent cation ionophore. , 1972, The Journal of biological chemistry.

[51]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[52]  D. Butterfield,et al.  Measurement of oxidized/reduced glutathione ratio. , 2010, Methods in molecular biology.

[53]  G. Scambia,et al.  Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange , 2007, Nature Protocols.