The flavonoid quercetin in disease prevention and therapy: facts and fancies.

[1]  Sven Diederichs,et al.  The hallmarks of cancer , 2012, RNA biology.

[2]  W. Hennink,et al.  PEG-OCL micelles for quercetin solubilization and inhibition of cancer cell growth. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  T. Kooistra,et al.  Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. , 2011, Atherosclerosis.

[4]  A. Bast,et al.  Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. , 2011, Clinical nutrition.

[5]  M. Diederich,et al.  Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation , 2011, British Journal of Cancer.

[6]  R. Müller,et al.  Preparation and characterization of quercetin nanocrystals. , 2011, Journal of pharmaceutical sciences.

[7]  James S. Duncan,et al.  A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling , 2011, Science Signaling.

[8]  Salvatore Panico,et al.  Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. , 2011, European heart journal.

[9]  B. Rocha,et al.  Quercetin-PVP K25 solid dispersions , 2011 .

[10]  I. Degirmenci,et al.  Effects of various agents on DNA fragmentation and telomerase enzyme activities in adenocarcinoma cell lines , 2011, Molecular Biology Reports.

[11]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[12]  R. Kiss,et al.  Quercetin inhibits a large panel of kinases implicated in cancer cell biology. , 2011, International journal of oncology.

[13]  P. Elumalai,et al.  Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC‐3) , 2011, Cell biochemistry and function.

[14]  Zigang Dong,et al.  Molecular targets of phytochemicals for cancer prevention , 2011, Nature Reviews Cancer.

[15]  U. Nöthlings,et al.  Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). , 2011, Journal of the National Cancer Institute.

[16]  M. Mcintosh,et al.  Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media , 2011, International Journal of Obesity.

[17]  G. Xie,et al.  Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. , 2010, The American journal of clinical nutrition.

[18]  Xianglin Shi,et al.  Quercetin Induces Tumor-Selective Apoptosis through Downregulation of Mcl-1 and Activation of Bax , 2010, Clinical Cancer Research.

[19]  Bikram Singh,et al.  Development of biodegradable nanoparticles for delivery of quercetin. , 2010, Colloids and surfaces. B, Biointerfaces.

[20]  D. Bataille,et al.  Quercetin potentiates insulin secretion and protects INS‐1 pancreatic β‐cells against oxidative damage via the ERK1/2 pathway , 2010, British journal of pharmacology.

[21]  G. Russo,et al.  Exploring death receptor pathways as selective targets in cancer therapy. , 2010, Biochemical pharmacology.

[22]  M. Büchler,et al.  Dietary polyphenol quercetin targets pancreatic cancer stem cells. , 2010, International journal of oncology.

[23]  G. Russo,et al.  Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients , 2010, British Journal of Cancer.

[24]  M. Broggini,et al.  Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analogue , 2010, Cancer Prevention Research.

[25]  D. Nieman,et al.  The variable plasma quercetin response to 12-week quercetin supplementation in humans , 2010, European Journal of Clinical Nutrition.

[26]  P. S. M. Prince,et al.  Pretreatment with quercetin ameliorates lipids, lipoproteins and marker enzymes of lipid metabolism in isoproterenol treated cardiotoxic male Wistar rats. , 2010, European journal of pharmacology.

[27]  N. Colburn,et al.  Interleukin-6 as a Potential Indicator for Prevention of High-Risk Adenoma Recurrence by Dietary Flavonols in the Polyp Prevention Trial , 2010, Cancer Prevention Research.

[28]  Sun-Hee Kim,et al.  Quercetin Enhances Susceptibility to NK Cell-mediated Lysis of Tumor Cells Through Induction of NKG2D Ligands and Suppression of HSP70 , 2010, Journal of immunotherapy.

[29]  J. H. Kim,et al.  Quercetin suppresses HeLa cell viability via AMPK‐induced HSP70 and EGFR down‐regulation , 2010, Journal of cellular physiology.

[30]  F. Sicheri,et al.  Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. , 2010, Molecular cell.

[31]  D. Nieman,et al.  Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial , 2010, Pharmacological Research.

[32]  K. Lee,et al.  Naturally occurring phytochemicals for the prevention of Alzheimer’s disease , 2010, Journal of neurochemistry.

[33]  D. Hardie,et al.  Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. , 2010, Biochimica et biophysica acta.

[34]  N. Sassi,et al.  Impact of mitochondriotropic quercetin derivatives on mitochondria. , 2010, Biochimica et biophysica acta.

[35]  G. Rimbach,et al.  Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. , 2010, The Journal of nutrition.

[36]  P. Hrelia,et al.  Sulforaphane as an inducer of glutathione prevents oxidative stress‐induced cell death in a dopaminergic‐like neuroblastoma cell line , 2009, Journal of neurochemistry.

[37]  Jin-Taek Hwang,et al.  AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. , 2009, New biotechnology.

[38]  E. Filippi-Chiela,et al.  Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells , 2009, Cancer science.

[39]  P. Limtrakul,et al.  Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids , 2009, Acta Pharmacologica Sinica.

[40]  Honghao Zhou,et al.  SIMULTANEOUS ACTION OF THE FLAVONOID QUERCETIN ON CYTOCHROME P450 (CYP) 1A2, CYP2A6, N‐ACETYLTRANSFERASE AND XANTHINE OXIDASE ACTIVITY IN HEALTHY VOLUNTEERS , 2009, Clinical and experimental pharmacology & physiology.

[41]  D. Nieman,et al.  Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. , 2009, Medicine and science in sports and exercise.

[42]  J. Schrezenmeir,et al.  Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study , 2009, British Journal of Nutrition.

[43]  H. Choo,et al.  In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates. , 2009, Bioorganic & medicinal chemistry.

[44]  S. Bae,et al.  Effects of Antioxidant Supplements Intervention on the Level of Plasma Inflammatory Molecules and Disease Severity of Rheumatoid Arthritis Patients , 2009, Journal of the American College of Nutrition.

[45]  C. Auger,et al.  Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats. , 2008, Journal of agricultural and food chemistry.

[46]  P. Allavena,et al.  Cancer-related inflammation , 2008, Nature.

[47]  A. Bast,et al.  Health effects of quercetin: from antioxidant to nutraceutical. , 2008, European journal of pharmacology.

[48]  Sang Gyun Kim,et al.  Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. , 2008, Cancer research.

[49]  Rebecca C Taylor,et al.  Apoptosis: controlled demolition at the cellular level , 2008, Nature Reviews Molecular Cell Biology.

[50]  E. A. Rogozin,et al.  Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. , 2008, Cancer research.

[51]  G. Williams,et al.  A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[52]  S. Litwin,et al.  Quercetin reduces blood pressure in hypertensive subjects. , 2007, The Journal of nutrition.

[53]  G. Russo Ins and outs of dietary phytochemicals in cancer chemoprevention. , 2007, Biochemical pharmacology.

[54]  P. Hrelia,et al.  Sulforaphane as a promising molecule for fighting cancer. , 2007, Mutation research.

[55]  S. Shirasawa,et al.  Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. , 2007, Carcinogenesis.

[56]  F. Prósper,et al.  Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. , 2007, Blood.

[57]  Yong J. Lee,et al.  TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation , 2007, Journal of cellular biochemistry.

[58]  G. Russo,et al.  Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines , 2007, Leukemia.

[59]  B. Ye,et al.  Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models , 2006, Clinical Cancer Research.

[60]  D. Barron,et al.  Divergent effects of quercetin conjugates on angiogenesis , 2006, British Journal of Nutrition.

[61]  A. Mitra,et al.  MDR- and CYP3A4-mediated drug-herbal interactions. , 2006, Life sciences.

[62]  V.M. Zohrabian,et al.  The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. , 2006, Anticancer research.

[63]  T. Okamoto Safety of quercetin for clinical application (Review). , 2005, International journal of molecular medicine.

[64]  S. Wolffram,et al.  Tissue distribution of quercetin in rats and pigs. , 2005, The Journal of nutrition.

[65]  Chul-hak Yang,et al.  Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. , 2005, Biochemical and biophysical research communications.

[66]  Gary Williamson,et al.  Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. , 2004, Mutation research.

[67]  G. Beecher,et al.  Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. , 2004, Annual review of nutrition.

[68]  A. Lee,et al.  Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. , 2004, Biochemical pharmacology.

[69]  Liliana Jiménez,et al.  Polyphenols: food sources and bioavailability. , 2004, The American journal of clinical nutrition.

[70]  Y. Surh,et al.  Cancer chemoprevention with dietary phytochemicals , 2003, Nature Reviews Cancer.

[71]  D. Fabbro,et al.  Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). , 2003, The Biochemical journal.

[72]  C. Rice-Evans,et al.  Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability* , 2003, Journal of Biological Chemistry.

[73]  P. Hollman,et al.  Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. , 2003, The Journal of nutrition.

[74]  G. Iacomino,et al.  Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα , 2003, Oncogene.

[75]  T. Tsuruo,et al.  Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. , 2003, Cancer research.

[76]  Jian Ding,et al.  Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. , 2003, European journal of pharmacology.

[77]  H. Hara,et al.  Suppression of Intestinal Crypt Cell Proliferation and Aberrant Crypt Foci by Dietary Quercetin in Rats , 2002, Nutrition and cancer.

[78]  H. Reber,et al.  Food‐derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis , 2002, International journal of cancer.

[79]  J. Tamargo,et al.  Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. , 2002, Planta medica.

[80]  S. J. Lee,et al.  Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. , 2001, International journal of oncology.

[81]  F. Casagrande,et al.  Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. , 2001, Biochemical pharmacology.

[82]  S. A. Hussain,et al.  Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

[83]  Roger L. Williams,et al.  Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. , 2000, Molecular cell.

[84]  G. Williamson,et al.  Dietary intake and bioavailability of polyphenols. , 2000, The Journal of nutrition.

[85]  D. Lamson,et al.  Antioxidants and cancer, part 3: quercetin. , 2000, Alternative medicine review : a journal of clinical therapeutic.

[86]  G. Iacomino,et al.  Quercetin and anti‐CD95(Fas/Apo1) enhance apoptosis in HPB‐ALL cell line , 1999, FEBS letters.

[87]  G. W. Peet,et al.  IκB Kinases α and β Show a Random Sequential Kinetic Mechanism and Are Inhibited by Staurosporine and Quercetin* , 1999, The Journal of Biological Chemistry.

[88]  E. Middleton,et al.  Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor , 1999, British journal of pharmacology.

[89]  B. Holub,et al.  Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. , 1998, The Journal of nutrition.

[90]  John Kuriyan,et al.  Crystal structure of the Src family tyrosine kinase Hck , 1997, Nature.

[91]  D. Kerr,et al.  Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[92]  P. Hollman,et al.  Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. , 1995, The American journal of clinical nutrition.

[93]  D Kromhout,et al.  Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. , 1995, Archives of internal medicine.

[94]  E. Feskens,et al.  Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study , 1993, The Lancet.

[95]  M. Yoshizumi,et al.  Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. , 2011, Journal of pharmacological sciences.

[96]  Raymond J Carroll,et al.  Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. , 2009, The Journal of nutrition.

[97]  Y. Kwon,et al.  Effects of low dose quercetin: Cancer cell‐specific inhibition of cell cycle progression , 2009, Journal of cellular biochemistry.

[98]  R. Stierum,et al.  Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis , 2008, Proteomics.

[99]  Gary Williamson,et al.  Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. , 2005, The American journal of clinical nutrition.

[100]  T. Vree,et al.  Human Nutrition and Metabolism—Research Communication Bioavailabilities of Quercetin-3- Glucoside and Quercetin-4*- Glucoside Do Not Differ in Humans , 2000 .