Video capsule endoscopy of the small bowel

Purpose of review It is now more than 6 years since capsule endoscopy was first introduced to the gastroenterological community. This disposable 26 × 11 mm video capsule, containing its own optical dome, light source, batteries, transmitter and antenna, is swallowed with water after a 12 h fast. The capsule is propelled via peristalsis through the gastrointestinal tract, capturing about 60 000 digital images, and is excreted naturally. Capsule endoscopy has become a first-line tool for detecting abnormalities in the small bowel, because all other imaging technologies are rather ineffective. This review covers recent developments in capsule endoscopy technology and provides an update of its main indications. Recent findings There are some clear indications for capsule endoscopy: obscure gastrointestinal bleeding, suspected small bowel tumour (in which it is becoming a primary investigational tool), suspected Crohn's disease, surveillance of inherited polyposis syndromes, drug-induced small bowel injury, and any abnormal small bowel imaging. Controversy persists regarding what is a normal small bowel appearance, which is exacerbated by the inability to take biopsies and thus differentiate between entities; with technological advances, however, it is hoped that this will be addressed. Summary Capsule endoscopy has been incorporated into the gastroenterologists' daily life, changing the approach to many small bowel pathologies.

[1]  M. Appleyard,et al.  Diagnosis and Outcome of Small Bowel Tumors Found by Capsule Endoscopy: A Three-Center Australian Experience , 2006, The American Journal of Gastroenterology.

[2]  T. Matsui,et al.  Chronic nonspecific multiple ulcers of the small intestine: a proposal of the entity from Japanese gastroenterologists to Western enteroscopists. , 2007, Gastrointestinal endoscopy.

[3]  D. Morgan,et al.  Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy. , 2007, Gastrointestinal endoscopy.

[4]  Gregory B Haber,et al.  Capsule endoscopy in obscure gastrointestinal bleeding. , 2004, Gastrointestinal endoscopy clinics of North America.

[5]  S. Ladas,et al.  Does Purgative Preparation Influence the Diagnostic Yield of Small Bowel Video Capsule Endoscopy?: A Meta-Analysis , 2009, The American Journal of Gastroenterology.

[6]  G. Liguori,et al.  Controlled study using wireless capsule endoscopy for the evaluation of the small intestine in chronic refractory pouchitis , 2007, Alimentary pharmacology & therapeutics.

[7]  C. Sakamoto,et al.  Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy. , 2009, Gastrointestinal endoscopy.

[8]  A. Hara,et al.  Capsule Endoscopy Has a Significantly Higher Diagnostic Yield in Patients With Suspected and Established Small-Bowel Crohn's Disease: A Meta-Analysis , 2010, The American Journal of Gastroenterology.

[9]  M. Lapalus,et al.  Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. , 2009, The New England journal of medicine.

[10]  Victoria Porter,et al.  Negative capsule endoscopy in patients with obscure GI bleeding predicts low rebleeding rates. , 2008, Gastrointestinal endoscopy.

[11]  Ananya Das,et al.  Double-balloon enteroscopy and capsule endoscopy have comparable diagnostic yield in small-bowel disease: a meta-analysis. , 2008, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[12]  J. A. Leighton,et al.  Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus , 2009, Endoscopy.

[13]  D. Cave,et al.  ICCE Consensus for Bowel Preparation and Prokinetics , 2005, Endoscopy.

[14]  J. A. Leighton,et al.  ICCE consensus for inflammatory bowel disease. , 2005, Endoscopy.

[15]  B. Lewis,et al.  Increased diagnostic yield of small bowel tumors with capsule endoscopy , 2006, Cancer.

[16]  J. Barkin,et al.  Wireless Capsule Endoscopy requiring surgical intervention: the world’s experience , 2002 .

[17]  K. Chayama,et al.  Comparison of detectability of small-bowel lesions between capsule endoscopy and double-balloon endoscopy for patients with suspected small-bowel disease. , 2009, Gastrointestinal endoscopy.

[18]  Paul Swain,et al.  Remote magnetic control of a wireless capsule endoscope in the esophagus is safe and feasible: results of a randomized, clinical trial in healthy volunteers. , 2010, Gastrointestinal endoscopy.

[19]  P. Swain,et al.  Wireless capsule endoscopy. , 2002, The Israel Medical Association journal : IMAJ.

[20]  E. Seidman,et al.  Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change , 2007, Alimentary pharmacology & therapeutics.

[21]  E. Rondonotti,et al.  Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. , 2004, Gastroenterology.

[22]  S. Song,et al.  First clinical trial of the "MiRo" capsule endoscope by using a novel transmission technology: electric-field propagation. , 2009, Gastrointestinal endoscopy.

[23]  D. Heresbach,et al.  Capsule endoscopy and bowel preparation with oral sodium phosphate: a prospective randomized controlled trial. , 2008, Gastrointestinal endoscopy.

[24]  Petia Radeva,et al.  New insight into intestinal motor function via noninvasive endoluminal image analysis. , 2008, Gastroenterology.

[25]  C. Fraser,et al.  Video capsule endoscopy in peutz-jeghers syndrome: a blinded comparison with barium follow-through for detection of small-bowel polyps. , 2006, Endoscopy.

[26]  D. Faigel,et al.  A multicenter randomized comparison of the Endocapsule and the Pillcam SB. , 2008, Gastrointestinal endoscopy.

[27]  Y. Niv Efficiency of bowel preparation for capsule endoscopy examination: a meta-analysis. , 2008, World journal of gastroenterology.

[28]  R. Jian,et al.  Capsule endoscopy or push enteroscopy for first-line exploration of obscure gastrointestinal bleeding? , 2007, Gastroenterology.

[29]  A. Hara,et al.  A Meta-Analysis of the Yield of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Obscure Gastrointestinal Bleeding , 2005, The American Journal of Gastroenterology.

[30]  R. Weersma,et al.  Risk factors for incomplete small-bowel capsule endoscopy. , 2009, Gastrointestinal endoscopy.

[31]  D. Graham,et al.  Visible small-intestinal mucosal injury in chronic NSAID users. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[32]  R Eliakim,et al.  Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. , 2009, Endoscopy.

[33]  M Pennazio,et al.  ICCE consensus for obscure gastrointestinal bleeding. , 2005, Endoscopy.

[34]  Amy K Hara,et al.  A Meta-Analysis of the Yield of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Non-Stricturing Small Bowel Crohn's Disease , 2006, The American Journal of Gastroenterology.

[35]  J Murray,et al.  ICCE consensus for celiac disease. , 2005, Endoscopy.

[36]  B. Lewis,et al.  ICCE consensus for capsule retention. , 2005, Endoscopy.

[37]  J. Galmiche,et al.  Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified) , 2007, Inflammatory bowel diseases.

[38]  C. Fraser,et al.  Are bowel purgatives and prokinetics useful for small-bowel capsule endoscopy? A prospective randomized controlled study. , 2009, Gastrointestinal endoscopy.

[39]  R. Eliakim,et al.  Video capsule endoscopy of the small bowel. , 2008, Current opinion in gastroenterology.

[40]  Y. Niv,et al.  Capsule endoscopy: role of bowel preparation in successful visualization , 2004, Scandinavian journal of gastroenterology.

[41]  Effect of oral purgatives on gastric and small bowel transit time in capsule endoscopy. , 2004, The Israel Medical Association journal : IMAJ.

[42]  V. Pons Beltrán,et al.  Evaluation of postsurgical recurrence in Crohn's disease: a new indication for capsule endoscopy? , 2007, Gastrointestinal endoscopy.

[43]  S. Giday,et al.  How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center. , 2008, Gastrointestinal endoscopy.

[44]  Y. Hirooka,et al.  Endoscopic resection of Peutz-Jeghers polyps throughout the small intestine at double-balloon enteroscopy without laparotomy. , 2005, Gastrointestinal endoscopy.

[45]  Peter Bauerfeind,et al.  Improved capsule endoscopy after bowel preparation. , 2005, Gastrointestinal endoscopy.

[46]  Z. Liao,et al.  Fields of applications, diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients. , 2010, World journal of gastroenterology.

[47]  Z. Ge,et al.  The role of capsule endoscopy combined with double-balloon enteroscopy in diagnosis of small bowel diseases. , 2007, Chinese medical journal.

[48]  B. Thjódleifsson,et al.  A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. , 2005, Gastroenterology.

[49]  M. Fornasarig,et al.  Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis. , 2008, Gastrointestinal endoscopy.

[50]  J. Leighton,et al.  Retention of the capsule endoscope: a single-center experience of 1000 capsule endoscopy procedures. , 2008, Gastrointestinal endoscopy.

[51]  J. Barkin,et al.  Small-Bowel Tumors Detected by Wireless Capsule Endoscopy , 2007, Digestive Diseases and Sciences.