The Use of 3D Printing in the Fabrication of Nasal Stents

Nasoalveolar molding of the cleft lip, nose, and alveolar palate has been a successful strategy for the restoration of oronasal function and appearance, but it has some drawbacks. The temporary implant that is inserted before surgical reconstruction is a large appliance requiring numerous adjustments, it can irritate delicate soft tissues, and interfere with the infant’s ability to nurse or feed. In the early post-operative period and for months after cleft lip repair, patients wear standardized silicone stents that come in multiple sizes, but require significant sculpting to fit the unique cleft deformity. Three-dimensional (3D) printing offers the potential of highly personalized and patient-specific treatment. We developed a method that produces a customized 3D printed stent that matches the contours and unique features of each patient and permits modification and adjustments in size and shape as the patient ages. With 3D scanning technology, the device can be designed at the first visit to create an appliance that can be worn sequentially with minimal trauma, does not impede feeding, and a prosthesis that will improve compliance. The device will be worn intraorally to help shape the alveolus, lip, and nose before surgical repair. Furthermore, the stent can be doped with drugs as each patient’s case warrants.

[1]  Jeffrey W Stansbury,et al.  3D printing with polymers: Challenges among expanding options and opportunities. , 2016, Dental materials : official publication of the Academy of Dental Materials.

[2]  M. Radisic,et al.  Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis , 2016, Nature materials.

[3]  N. Alonso,et al.  Protocols in Cleft Lip and Palate Treatment: Systematic Review , 2012, Plastic surgery international.

[4]  Brian Derby,et al.  Printing and Prototyping of Tissues and Scaffolds , 2012, Science.

[5]  Anthony Atala,et al.  Printing Technologies for Medical Applications. , 2016, Trends in molecular medicine.

[6]  R. Battle Cleft lip and palate. , 1955, The Practitioner.

[7]  R. Bracci,et al.  Bioresorbable Airway Splint Created with a Three-Dimensional Printer , 2013 .

[8]  R. Kirby,et al.  Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006. , 2010, Birth defects research. Part A, Clinical and molecular teratology.

[9]  A. Bandyopadhyay,et al.  Bone tissue engineering using 3D printing , 2013 .

[10]  D. Mills,et al.  Nanoenhanced hydrogel system with sustained release capabilities. , 2015, Journal of biomedical materials research. Part A.

[11]  Nicholas Herbert,et al.  A preliminary investigation into the development of 3-D printing of prosthetic sockets. , 2005, Journal of rehabilitation research and development.

[12]  Udayabhanu M. Jammalamadaka,et al.  Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications , 2015, International journal of nanomedicine.

[13]  Y. Lvov,et al.  Functional polymer–clay nanotube composites with sustained release of chemical agents , 2013 .

[14]  Robert Langer,et al.  Advances in tissue engineering. , 2004, Current topics in developmental biology.

[15]  Lorenzo Moroni,et al.  Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regeneration , 2016, Biofabrication.

[16]  Shaun Eshraghi,et al.  Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering. , 2010, Acta biomaterialia.

[17]  Emanuel M. Sachs,et al.  Three-dimensional printing technique , 1990 .

[18]  B. Duan,et al.  3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels. , 2013, Journal of biomedical materials research. Part A.

[19]  I. Zein,et al.  Fused deposition modeling of novel scaffold architectures for tissue engineering applications. , 2002, Biomaterials.

[20]  Rolf Mülhaupt,et al.  Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer‐assisted design combined with computer‐guided 3D plotting of polymers and reactive oligomers , 2000 .

[21]  Lin Xiao,et al.  Poly(Lactic Acid)-Based Biomaterials: Synthesis, Modification and Applications , 2012 .

[22]  Udayabhanu M. Jammalamadaka,et al.  Three‐dimensional printing of bioactive hernia meshes: In vitro proof of principle , 2017, Surgery.

[23]  G. Wehby,et al.  The impact of orofacial clefts on quality of life and healthcare use and costs. , 2010, Oral diseases.

[24]  Udayabhanu M. Jammalamadaka,et al.  Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices , 2017, Bioengineering.

[25]  Martine Dubé,et al.  Three‐Dimensional Printing of Multifunctional Nanocomposites: Manufacturing Techniques and Applications , 2016, Advanced materials.

[26]  A. Rahoma Complete Cleft Palate: A New Scheme Of Treatment , 2006 .

[27]  Ibrahim T. Ozbolat,et al.  Bioprinting Toward Organ Fabrication: Challenges and Future Trends , 2013, IEEE Transactions on Biomedical Engineering.

[28]  Jerry Y H Fuh,et al.  3D Printing and 3D Bioprinting in Pediatrics , 2017, Bioengineering.

[29]  Benjamin M Wu,et al.  Recent advances in 3D printing of biomaterials , 2015, Journal of Biological Engineering.

[30]  T. Beaty,et al.  Cleft lip and palate: understanding genetic and environmental influences , 2011, Nature Reviews Genetics.

[31]  Chris Hayhurst Is this the future of medical technology? , 2014, Biomedical instrumentation & technology.

[32]  M. Chen,et al.  Cleft Lip – A Comprehensive Review , 2013, Front. Pediatr..

[33]  Sailing He,et al.  Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography , 2012, Advanced materials.

[34]  Deepika Jijotiya,et al.  A Survey of Performance based Advanced Rapid Prototyping Techniques , 2013 .

[35]  Nicholas B Langhals,et al.  Innovations in Prosthetic Interfaces for the Upper Extremity , 2013, Plastic and reconstructive surgery.

[36]  Barry H. Grayson,et al.  Presurgical nasoalveolar moulding treatment in cleft lip and palate patients , 2009, Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India.