Cell morphology based classification for red cells in blood smear images

The proposed a hybrid neural network architecture for red cell classification.The separation of overlapping cells have been attempted.Utilized all visual features extracted from red cell images with new classifier.Improvement in red cell normality classification result.Capable of accurately distinguish different blood diseases. Red blood cells are the most common type of blood cell and are responsible of delivering oxygen to the body tissues. Abnormalities in red blood cell may change the physical properties of the red cell or shorten its life spend, and may lead to stroke or anemia. In this paper, we proposed a hybrid neural network based classifier, which utilize the visual information extracted from the red blood cell images to determine whether a red cell is normal or abnormal. Based on the feature properties, we clustered the visual features into two main groups, namely shape and texture cluster groups. The input feature clusters were processed using parallel and cascade architecture with multiple input layers. Our experimental result has shown significant improvement in classification accuracy in our proposed system as compared to the single input layer classifier with recent feature selection algorithms.

[1]  Yi-Ping Phoebe Chen,et al.  Skin cancer extraction with optimum fuzzy thresholding technique , 2013, Applied Intelligence.

[2]  H. Rabbani,et al.  Classification of three types of red blood cells in peripheral blood smear based on morphology , 2010, IEEE 10th INTERNATIONAL CONFERENCE ON SIGNAL PROCESSING PROCEEDINGS.

[3]  Brendan McCane,et al.  Red blood cell segmentation using guided contour tracing , 2006 .

[4]  Isabelle Guyon,et al.  An Introduction to Variable and Feature Selection , 2003, J. Mach. Learn. Res..

[5]  Jiyuan An,et al.  DDR: an index method for large time-series datasets , 2005, Inf. Syst..

[6]  L L Wheeless,et al.  Classification of red blood cells as normal, sickle, or other abnormal, using a single image analysis feature. , 1994, Cytometry.

[7]  Fuhui Long,et al.  Feature selection based on mutual information criteria of max-dependency, max-relevance, and min-redundancy , 2003, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[8]  Yi-Ping Phoebe Chen,et al.  A scalable and extensible segment-event-object-based sports video retrieval system , 2008, TOMCCAP.

[9]  C. Lomas‐Francis,et al.  Blood groups and diseases associated with inherited abnormalities of the red blood cell membrane. , 2000, Transfusion medicine reviews.

[10]  Xu Jun,et al.  The recognition and analysis system of blood cells , 2000, Proceedings of the 3rd World Congress on Intelligent Control and Automation (Cat. No.00EX393).

[11]  Qi Tian,et al.  Feature selection using principal feature analysis , 2007, ACM Multimedia.

[12]  O. Platt,et al.  Mortality in sickle cell disease. Life expectancy and risk factors for early death. , 1994, The New England journal of medicine.

[13]  Jacek M. Zurada,et al.  Normalized Mutual Information Feature Selection , 2009, IEEE Transactions on Neural Networks.

[14]  Yi-Ping Phoebe Chen,et al.  Kernel-based naive bayes classifier for breast cancer prediction , 2007 .

[15]  Le Song,et al.  Supervised feature selection via dependence estimation , 2007, ICML '07.

[16]  Qingfeng Chen,et al.  Mining frequent patterns for AMP-activated protein kinase regulation on skeletal muscle , 2006, BMC Bioinformatics.

[17]  N. Mohandas,et al.  Disorders of red cell membrane , 2008, British journal of haematology.

[18]  Hiroshi Motoda,et al.  Computational Methods of Feature Selection , 2022 .

[19]  Lei Wang,et al.  Feature Selection With Redundancy-Constrained Class Separability , 2010, IEEE Transactions on Neural Networks.

[20]  Yi-Ping Phoebe Chen,et al.  Cell cycle phase detection with cell deformation analysis , 2014, Expert Syst. Appl..

[21]  B. McCane,et al.  Red blood cell segmentation from SEM images , 2009, 2009 24th International Conference Image and Vision Computing New Zealand.

[22]  Yo-Sung Ho,et al.  Automatic Cell Classification in Human's Peripheral Blood Images Based on Morphological Image Processing , 2001, Australian Joint Conference on Artificial Intelligence.

[23]  Marco Zaffalon,et al.  Robust Feature Selection by Mutual Information Distributions , 2002, UAI.

[24]  Bernhard G. Zagar,et al.  Image processing strategies to accurately measure red blood cell motion in superficial capillaries , 2009, 2009 6th International Multi-Conference on Systems, Signals and Devices.

[25]  Daniel P. Huttenlocher,et al.  Comparing Images Using the Hausdorff Distance , 1993, IEEE Trans. Pattern Anal. Mach. Intell..

[26]  I. Cseke,et al.  A fast segmentation scheme for white blood cell images , 1992, Proceedings., 11th IAPR International Conference on Pattern Recognition. Vol. III. Conference C: Image, Speech and Signal Analysis,.